Native Alzheimer Disease Resource Center for Minority Aging Research (NAD-RCMAR)

少数民族老龄化研究本地阿尔茨海默病资源中心 (NAD-RCMAR)

• 批准号: 10729899
• 负责人: Astrid M Suchy-Dicey
• 金额: $ 7.52万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10729899
• 关键词: Address; Affect; Aging; Alaska Native; Alzheimer' s Disease; Alzheimer' s disease related dementia; American Indians; Applications Grants; Behavioral Research; Biological Markers; Biometry; Birth; Clinical; Clinical Data; Clinical Research; Cognition; Collaborations; Computerized Medical Record; Consultations; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Set; Databases; Diagnosis; Disease; Disparity; Epidemiology; Ethnic Population; Funding; Goals; Grant; Health; Incidence; Instruction; Knowledge; Learning; Mentors; Methodology; Methods; Minority; Native Hawaiian or Other Pacific Islander; Outcome; Participant; Persons; Pilot Projects; Play; Policies; Population; Population Study; Positioning Attribute; Prevalence; Public Health; Publications; Reporting; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Role; Sample Size; Sampling; Scientist; Structure; Surveys; Techniques; Training; United States Dept. of Health and Human Services; Work; Writing; career; cohort; comorbidity; data management; data repository; data sharing; dementia risk; design; education research; experience; health disparity; health equity; improved; patient stratification; population based; pressure; programs; public health research; racial population; research faculty; resilience; resilience factor; risk stratification; social; social health determinants; socioeconomic disparity; success; undue influence

ABSTRACT – Analysis Core Healthy People 2030, a decennial public health roadmap set by the US Department of Health and Human Services, calls for public health research and policy focused on improving health equity, with key objectives related to social determinants of health, including resilience against negative health outcomes. Despite prior Healthy People objectives to address health disparities among different racial/ethnic groups, the conditions of birth, learning, labor, and aging continue to unduly influence health outcomes, further exacerbated by prevalent socioeconomic inequities. Disparities affecting American Indians and Alaska Natives (AI/AN) and Native Hawaiians/Pacific Islanders (NHPI) are exceptionally persistent, and are especially problematic in diseases of aging, such as Alzheimer’s disease and related dementias (ADRD). A key knowledge gap is that methods to identify, diagnose, and risk stratify patients have not been adapted for use in AI/AN and NHPI, who have unique social, environmental, and access pressures influencing ADRD prevalence, diagnosis, and characterization. Thus, specific approaches for studying ADRD in AI/AN and NHPI are urgently needed. This Native Alzheimer’s Disease Resource Center in Minority Aging Research (NAD-RCMAR) is well positioned to enable early-stage investigators to conduct impactful Pilot Studies on ADRD risk and resilience factors in AI/AN and NHPI, by using mentoring and structured analytic techniques designed to yield strong conclusions and serve as preliminary data for grant proposals. The NAD-RCMAR Analysis Core (AnC) is structured to emphasize methods training, mentoring, and support in ADRD research affecting AI/AN and NHPI populations. Our AnC is well positioned to support NAD-RCMAR Scientists with methods mentoring and biostatistics support for Pilot Studies; methods consultation for grant writing; partner with other NAD-RCMAR components to provide didactic instruction; and develop a research resource of datasets focused on ADRD risk and resilience in AI/AN and NHPI. Our Specific Aims are to (1) Collaborate with Research Education Component (REC) to provide mentoring and didactic instruction to NAD-RCMAR Scientists, with a focus on methods for data collection and analysis in risk and resilience of ADRD disparities affecting AI/AN and NHPI; (2) Collaborate with NAD-RCMAR faculty so that NAD- RCMAR Scientists can design, conduct, analyze and interpret high-quality research on risk and resilience disparities in ADRD among AI/AN and NHPI; (3) Provide structured support to NAD-RCMAR Scientists in data management, analysis, and inference; (4) Maintain and develop a database of studies with data on ADRD risk and resilience in AI/AN and NHPI; and (5) Work with RCMAR Coordinating Center to share data and information. Overall, this AnC will help NAD-RCMAR Scientists to maximize scientific rigor while accommodating logistical and methodological challenges in studying ADRD in AI/AN and NHPI. Our overarching goal is to optimize the quality of research publications and grant proposals produced by NAD-RCMAR Scientists, to prepare them for independent contribution and success in a rapidly expanding field of research.

摘要 - 分析核心 健康人2030，美国卫生与人类部设置的十年期公共卫生路线图 服务，呼吁公共卫生研究和政策，重点是改善健康公平，并具有关键目标 与卫生的社会决定者有关，包括抵抗负面的健康结果。尽管先前 健康的人目的解决不同种族/族裔之间的健康差异 出生，学习，劳动和衰老继续不适当地影响健康成果，进一步受到普遍性的加剧 社会经济不平等。影响美国印第安人和阿拉斯加本地人（AI/AN）和本地的差异 夏威夷人/太平洋岛民（NHPI）非常持久，在 衰老，例如阿尔茨海默氏病和相关痴呆症（ADRD）。关键知识差距是方法 尚未适应具有独特的AI/AN和NHPI的使用，识别，诊断和风险分层患者 社会，环境和访问压力会影响ADRD的流行，诊断和表征。 迫切需要在AI/AN和NHPI中研究ADRD的特定方法。这个本地的阿尔茨海默氏症 少数民族老龄化研究中的疾病资源中心（NAD-RCMAR）的位置良好，可以实现早期 研究人员通过使用AI/AN和NHPI的ADRD风险和弹性因素的有影响力的试点研究 指导和结构化的分析技术旨在得出强烈的结论并作为初步数据 提出赠款。 NAD-RCMAR分析核心（ANC）的结构是强调方法训练， 对AI/AN和NHPI人群的ADRD研究的指导和支持。我们的ANC有很好的位置 为NAD-RCMAR科学家提供心理和生物统计学支持试点研究的方法；方法 授予写作咨询；与其他NAD-RCMAR组件合作以提供教学教学；和 开发数据集的研究资源，重点是AI/AN和NHPI中的ADRD风险和弹性。我们的具体 目的是（1）与研究教育部分（REC）合作以提供心理和教学 向NAD-RCMAR科学家的指导，重点是用于数据收集和分析风险和分析的方法 影响AI/AN和NHPI的ADRD差异的弹性； （2）与NAD-RCMAR教师合作，以便NAD- RCMAR科学家可以设计，进行，分析和解释有关风险和韧性的高质量研究 AI/AN和NHPI之间的ADRD差异； （3）在数据中为NAD-RCMAR科学家提供结构化支持 管理，分析和推理； （4）维护和开发具有有关ADRD风险数据的研究数据库 和AI/AN和NHPI中的弹性； （5）与RCMAR协调中心合作共享数据和信息。 总体而言，该ANC将帮助NAD-RCMAR科学家在适应后勤的同时最大程度地提高科学严谨性 以及在AI/AN和NHPI中研究ADRD的方法论挑战。我们的总体目标是优化 NAD-RCMAR科学家提出的研究出版物质量和赠款提案，以准备 在快速扩展的研究领域中的独立贡献和成功。