Native Alzheimer Disease Resource Center for Minority Aging Research (NAD-RCMAR)

摘要-分析核心 2030年健康人，由美国卫生与人类发展部制定的十年公共卫生路线图 服务，呼吁公共卫生研究和政策，重点是改善卫生公平，关键目标 与健康的社会决定因素有关，包括对负面健康结果的复原力。尽管现有 健康人的目标是解决不同种族/族裔群体之间的健康差距， 出生、学习、劳动和衰老继续不适当地影响健康结果， 社会经济不平等。影响美国印第安人和阿拉斯加原住民（AI/AN）和原住民的差异 夏威夷人/太平洋岛民（NHPI）是非常持久的，特别是在疾病的问题， 衰老，如阿尔茨海默病和相关痴呆症（ADRD）。一个关键的知识差距是， 识别、诊断和风险分层患者尚未适用于AI/AN和NHPI，它们具有独特 影响ADRD患病率、诊断和特征的社会、环境和获取压力。 因此，迫切需要研究AI/AN和NHPI中ADRD的具体方法。这种原生的阿尔茨海默氏症 少数民族老龄化研究疾病资源中心（NAD-RCMAR）处于有利地位， 研究人员将通过使用以下方法对AI/AN和NHPI中的ADRD风险和弹性因素进行有影响力的试点研究： 指导和结构化的分析技术，旨在产生强有力的结论，并作为初步数据 申请补助金NAD-RCMAR分析核心（AnC）的结构强调方法培训， 指导和支持影响AI/AN和NHPI人群的ADRD研究。我们的AnC处于有利地位， 为NAD-RCMAR科学家提供方法指导和生物统计学支持，用于试点研究;方法 与其他NAD-RCMAR组件合作提供教学指导;以及 开发数据集的研究资源，重点关注AI/AN和NHPI中的ADRD风险和弹性。我们的具体 目的是（1）与研究教育组成部分（REC）合作，提供指导和教学 指导NAD-RCMAR科学家，重点是数据收集和风险分析方法， 影响AI/AN和NHPI的ADRD差异的弹性;（2）与NAD-RCMAR教师合作，使NAD- RCMAR科学家可以设计，进行，分析和解释高质量的研究风险和弹性 AI/AN和NHPI之间ADRD的差异;（3）在数据方面为NAD-RCMAR科学家提供结构化支持 管理、分析和推理;（4）维护和开发包含ADRD风险数据的研究数据库 与RCMAR协调中心合作，共享数据和信息。 总的来说，这个AnC将帮助NAD-RCMAR科学家最大限度地提高科学严谨性，同时适应后勤保障。 在AI/AN和NHPI中研究ADRD的方法学挑战。我们的首要目标是优化 NAD-RCMAR科学家制作的研究出版物和赠款提案的质量， 在迅速扩大的研究领域中的独立贡献和成功。

ABSTRACT – Analysis Core Healthy People 2030, a decennial public health roadmap set by the US Department of Health and Human Services, calls for public health research and policy focused on improving health equity, with key objectives related to social determinants of health, including resilience against negative health outcomes. Despite prior Healthy People objectives to address health disparities among different racial/ethnic groups, the conditions of birth, learning, labor, and aging continue to unduly influence health outcomes, further exacerbated by prevalent socioeconomic inequities. Disparities affecting American Indians and Alaska Natives (AI/AN) and Native Hawaiians/Pacific Islanders (NHPI) are exceptionally persistent, and are especially problematic in diseases of aging, such as Alzheimer’s disease and related dementias (ADRD). A key knowledge gap is that methods to identify, diagnose, and risk stratify patients have not been adapted for use in AI/AN and NHPI, who have unique social, environmental, and access pressures influencing ADRD prevalence, diagnosis, and characterization. Thus, specific approaches for studying ADRD in AI/AN and NHPI are urgently needed. This Native Alzheimer’s Disease Resource Center in Minority Aging Research (NAD-RCMAR) is well positioned to enable early-stage investigators to conduct impactful Pilot Studies on ADRD risk and resilience factors in AI/AN and NHPI, by using mentoring and structured analytic techniques designed to yield strong conclusions and serve as preliminary data for grant proposals. The NAD-RCMAR Analysis Core (AnC) is structured to emphasize methods training, mentoring, and support in ADRD research affecting AI/AN and NHPI populations. Our AnC is well positioned to support NAD-RCMAR Scientists with methods mentoring and biostatistics support for Pilot Studies; methods consultation for grant writing; partner with other NAD-RCMAR components to provide didactic instruction; and develop a research resource of datasets focused on ADRD risk and resilience in AI/AN and NHPI. Our Specific Aims are to (1) Collaborate with Research Education Component (REC) to provide mentoring and didactic instruction to NAD-RCMAR Scientists, with a focus on methods for data collection and analysis in risk and resilience of ADRD disparities affecting AI/AN and NHPI; (2) Collaborate with NAD-RCMAR faculty so that NAD- RCMAR Scientists can design, conduct, analyze and interpret high-quality research on risk and resilience disparities in ADRD among AI/AN and NHPI; (3) Provide structured support to NAD-RCMAR Scientists in data management, analysis, and inference; (4) Maintain and develop a database of studies with data on ADRD risk and resilience in AI/AN and NHPI; and (5) Work with RCMAR Coordinating Center to share data and information. Overall, this AnC will help NAD-RCMAR Scientists to maximize scientific rigor while accommodating logistical and methodological challenges in studying ADRD in AI/AN and NHPI. Our overarching goal is to optimize the quality of research publications and grant proposals produced by NAD-RCMAR Scientists, to prepare them for independent contribution and success in a rapidly expanding field of research.