Native Alzheimer Disease Resource Center for Minority Aging Research (NAD-RCMAR)

少数民族老龄化研究本地阿尔茨海默病资源中心 (NAD-RCMAR)

• 批准号: 10729899
• 负责人: Astrid M Suchy-Dicey
• 金额: $ 7.52万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10729899
• 关键词: Address; Affect; Aging; Alaska Native; Alzheimer' s Disease; Alzheimer' s disease related dementia; American Indians; Applications Grants; Behavioral Research; Biological Markers; Biometry; Birth; Clinical; Clinical Data; Clinical Research; Cognition; Collaborations; Computerized Medical Record; Consultations; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Set; Databases; Diagnosis; Disease; Disparity; Epidemiology; Ethnic Population; Funding; Goals; Grant; Health; Incidence; Instruction; Knowledge; Learning; Mentors; Methodology; Methods; Minority; Native Hawaiian or Other Pacific Islander; Outcome; Participant; Persons; Pilot Projects; Play; Policies; Population; Population Study; Positioning Attribute; Prevalence; Public Health; Publications; Reporting; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Role; Sample Size; Sampling; Scientist; Structure; Surveys; Techniques; Training; United States Dept. of Health and Human Services; Work; Writing; career; cohort; comorbidity; data management; data repository; data sharing; dementia risk; design; education research; experience; health disparity; health equity; improved; patient stratification; population based; pressure; programs; public health research; racial population; research faculty; resilience; resilience factor; risk stratification; social; social health determinants; socioeconomic disparity; success; undue influence

ABSTRACT – Analysis Core Healthy People 2030, a decennial public health roadmap set by the US Department of Health and Human Services, calls for public health research and policy focused on improving health equity, with key objectives related to social determinants of health, including resilience against negative health outcomes. Despite prior Healthy People objectives to address health disparities among different racial/ethnic groups, the conditions of birth, learning, labor, and aging continue to unduly influence health outcomes, further exacerbated by prevalent socioeconomic inequities. Disparities affecting American Indians and Alaska Natives (AI/AN) and Native Hawaiians/Pacific Islanders (NHPI) are exceptionally persistent, and are especially problematic in diseases of aging, such as Alzheimer’s disease and related dementias (ADRD). A key knowledge gap is that methods to identify, diagnose, and risk stratify patients have not been adapted for use in AI/AN and NHPI, who have unique social, environmental, and access pressures influencing ADRD prevalence, diagnosis, and characterization. Thus, specific approaches for studying ADRD in AI/AN and NHPI are urgently needed. This Native Alzheimer’s Disease Resource Center in Minority Aging Research (NAD-RCMAR) is well positioned to enable early-stage investigators to conduct impactful Pilot Studies on ADRD risk and resilience factors in AI/AN and NHPI, by using mentoring and structured analytic techniques designed to yield strong conclusions and serve as preliminary data for grant proposals. The NAD-RCMAR Analysis Core (AnC) is structured to emphasize methods training, mentoring, and support in ADRD research affecting AI/AN and NHPI populations. Our AnC is well positioned to support NAD-RCMAR Scientists with methods mentoring and biostatistics support for Pilot Studies; methods consultation for grant writing; partner with other NAD-RCMAR components to provide didactic instruction; and develop a research resource of datasets focused on ADRD risk and resilience in AI/AN and NHPI. Our Specific Aims are to (1) Collaborate with Research Education Component (REC) to provide mentoring and didactic instruction to NAD-RCMAR Scientists, with a focus on methods for data collection and analysis in risk and resilience of ADRD disparities affecting AI/AN and NHPI; (2) Collaborate with NAD-RCMAR faculty so that NAD- RCMAR Scientists can design, conduct, analyze and interpret high-quality research on risk and resilience disparities in ADRD among AI/AN and NHPI; (3) Provide structured support to NAD-RCMAR Scientists in data management, analysis, and inference; (4) Maintain and develop a database of studies with data on ADRD risk and resilience in AI/AN and NHPI; and (5) Work with RCMAR Coordinating Center to share data and information. Overall, this AnC will help NAD-RCMAR Scientists to maximize scientific rigor while accommodating logistical and methodological challenges in studying ADRD in AI/AN and NHPI. Our overarching goal is to optimize the quality of research publications and grant proposals produced by NAD-RCMAR Scientists, to prepare them for independent contribution and success in a rapidly expanding field of research.

摘要 – 分析核心 Healthy People 2030，美国卫生与人类健康部制定的十年一次的公共卫生路线图 服务，呼吁公共卫生研究和政策以改善健康公平为主要目标 与健康的社会决定因素有关，包括抵御负面健康结果的能力。尽管之前 健康人的目标是解决不同种族/族裔群体之间的健康差异、 出生、学习、分娩和衰老继续对健康结果产生不当影响，而流行病进一步加剧了这种影响 社会经济不平等。影响美洲印第安人和阿拉斯加原住民 (AI/AN) 和原住民的差异 夏威夷人/太平洋岛民 (NHPI) 的顽固性特别强，尤其容易引发以下疾病： 衰老，例如阿尔茨海默病和相关痴呆症（ADRD）。一个关键的知识差距是方法 识别、诊断和风险分层患者尚未适用于 AI/AN 和 NHPI，它们具有独特的 影响 ADRD 患病率、诊断和特征的社会、环境和获取压力。 因此，迫切需要研究 AI/AN 和 NHPI 中 ADRD 的具体方法。这种原生阿尔茨海默病 少数族裔老龄化研究疾病资源中心 (NAD-RCMAR) 处于有利地位，可以实现早期阶段 研究人员对 AI/AN 和 NHPI 中的 ADRD 风险和复原力因素进行有影响力的试点研究，方法是使用 指导和结构化分析技术旨在产生强有力的结论并作为初步数据 拨款提案。 NAD-RCMAR 分析核心 (AnC) 的结构强调方法培训、 指导和支持影响 AI/AN 和 NHPI 人群的 ADRD 研究。我们的 AnC 处于有利地位 为 NAD-RCMAR 科学家提供试点研究的方法指导和生物统计学支持；方法 拨款申请咨询；与其他 NAD-RCMAR 组件合作提供教学指导；和 开发专注于 AI/AN 和 NHPI 中 ADRD 风险和复原力的数据集研究资源。我们的具体 目标是 (1) 与研究教育部分 (REC) 合作提供指导和教学 向 NAD-RCMAR 科学家提供指导，重点是风险和风险方面的数据收集和分析方法 影响 AI/AN 和 NHPI 的 ADRD 差异的恢复力； (2) 与 NAD-RCMAR 教师合作，以便 NAD- RCMAR 科学家可以设计、进行、分析和解释有关风险和复原力的高质量研究 AI/AN 和 NHPI 之间 ADRD 的差异； (3) 为NAD-RCMAR科学家提供数据方面的结构化支持 管理、分析和推理； (4) 维护和开发 ADRD 风险数据研究数据库 AI/AN 和 NHPI 的恢复能力； (5) 与RCMAR协调中心合作，共享数据和信息。 总体而言，该 AnC 将帮助 NAD-RCMAR 科学家最大限度地提高科学严谨性，同时适应后勤保障 AI/AN 和 NHPI 中 ADRD 研究的方法论挑战。我们的总体目标是优化 NAD-RCMAR 科学家发表的研究出版物和资助提案的质量，为他们做好准备 在快速扩展的研究领域中的独立贡献和成功。