Resilience, cultural alignment, and social support in brain aging: Data from the Strong Heart Study

大脑衰老过程中的复原力、文化一致性和社会支持：来自强心研究的数据

• 批准号: 10408836
• 负责人: Astrid M Suchy-Dicey
• 金额: $ 59.02万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10408836
• 关键词: Address; Adult; Age; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American Indians; Anger; Anthropology; Behavioral; Cardiovascular Diseases; Characteristics; Chronic; Chronic stress; Clinic; Clinical; Cognition; Cohort Studies; Communities; Consent; Contracts; Data; Data Analyses; Data Collection; Dementia; Development; Discrimination; Emotional; Emotions; Environment; Epidemiology; Event; Failure; Family; Female; Funding; Health; Heart; Hostility; Impaired cognition; Individual; Inflammation; Knowledge; Life; Life Stress; Link; Longitudinal cohort; Machine Learning; Mediating; Medical Genetics; Mental Depression; Methods; Modeling; National Heart, Lung, and Blood Institute; Navajo; Nerve Degeneration; Neuropsychology; Outcome; Participant; Patient-Centered Care; Persons; Philosophy; Population; Poverty; Protocols documentation; Psychosocial Factor; Public Health; Quality of life; Recording of previous events; Reporter; Research; Resources; Risk; Social Network; Social support; Socioeconomic Factors; Spirituality; Stress; Time; Trauma; Tribes; Underserved Population; United States National Institutes of Health; Work; Youth; aging brain; base; bullying; clinical examination; cognitive function; cognitive reserve; cohort; disability; eligible participant; epidemiology study; experience; healthy aging; heterogenous data; improved; instrument; intergenerational; machine learning classification; male; mortality; novel; optimism; practical application; psychosocial; public health intervention; recruit; resilience; screening; sex; sociodemographics; socioeconomics; theories; trait; tribal community

ABSTRACT When life stresses are especially intense, chronic, or overwhelming, deleterious health effects can occur, including inflammation, cardiovascular disease, disability, depression, low quality of life, and dementia. In this context, resilience can be defined as the ability to maintain a healthy aging trajectory despite adverse conditions of stress. American Indians (AI) have a unique history and ongoing experience of trauma and disparities in environmental and socioeconomic conditions, which amplify daily stresses and contribute to health risks. Despite these adverse circumstances, remarkable resilience has been described in AI populations. Recent work by our group suggests that social support and alignment with Native culture correlate with lower levels of stress, negativity, anger, hostility, depression, mortality, and cardiovascular disease. However, our findings on cultural alignment are limited, and none has yet explored associations of resilience and social support. It remains an open question whether neurodegenerative conditions such as Alzheimer's disease and related dementias (ADRD) can result from chronic stress, or whether individual psychosocial characteristics such as resilience can mediate such risk. We propose to address these knowledge gaps by efficiently leveraging an existing effort funded by the NHLBI in the Strong Heart Study, a longitudinal cohort of AI adults from 13 tribal communities across the US. The existing contract covers recruitment, consenting, and basic clinical examination of 3,000 eligible participants in 2022-2024; we propose to augment the limited protocol by administering additional psychosocial and neuropsychological instruments on resilience, social support, cultural identity and alignment, and cognition. Our Specific Aims are to: describe associations of individual resilience among AI adults with identity and self-regard, social support, and cultural alignment, by age and sex; evaluate resilience, social support, and cultural features in relation to ADRD; and use machine learning to develop explanatory models of resilience and dementia. Our study has the potential to advance epidemiologic knowledge of modifiable psychosocial conditions in a vulnerable, underserved population, and consequently to offer a clearer picture of the relative contributions of psychosocial, behavioral, interpersonal, and socioeconomic factors related to ADRD.

摘要 当生活压力特别强烈，慢性或压倒性时，可能会发生有害的健康影响， 包括炎症、心血管疾病、残疾、抑郁、低生活质量和痴呆。在这 在上下文中，弹性可以定义为在不利条件下保持健康老龄化轨迹的能力 压力美洲印第安人（AI）在创伤和不平等方面有着独特的历史和持续的经历， 环境和社会经济条件，这些条件放大了日常压力，并造成健康风险。尽管 在这些不利的情况下，AI种群中描述了显着的恢复力。我们最近的工作 研究小组认为，社会支持和与本土文化的一致性与较低的压力水平有关， 消极、愤怒、敌意、抑郁、死亡率和心血管疾病。然而，我们在文化上的发现 这些研究中，一致性是有限的，而且还没有人探索过复原力和社会支持之间的联系。它仍然是一个 神经退行性疾病，如阿尔茨海默病和相关痴呆症， （ADRD）可能是由慢性压力引起的，或者个体的心理社会特征，如弹性，是否可以 化解这样的风险。我们建议通过有效地利用现有的努力来解决这些知识差距 由NHLBI资助的强心研究，来自13个部落社区的AI成年人的纵向队列 在美国各地。现有的合同包括招募，同意和基本临床检查3，000人 2022-2024年合格参与者;我们建议通过管理额外的 关于复原力、社会支持、文化认同和一致性的社会心理和神经心理学工具， 和认知。我们的具体目标是：描述人工智能成年人中个体弹性的关联， 按年龄和性别分列的身份和自尊、社会支持和文化一致性; 支持和与ADRD相关的文化特征;并使用机器学习开发解释性模型， 恢复力和痴呆症我们的研究有可能提高对可改变的 社会心理状况，从而更清楚地了解 与ADRD相关的心理社会、行为、人际关系和社会经济因素的相对贡献。