Mechanistic Effects of Health Coaching to reduce COPD Hospitalizations

项目总结/摘要 这项研究的总体目标是进一步研究健康教练的各个方面， 这导致了第一个随机证据表明，健康指导减少了慢性阻塞性肺疾病的再次住院率。 肺疾病（COPD）。对这种干预的机械效应的拟议研究将导致创造 一个关于干预如何运作的理论框架。我们将进一步测试健康指导对 在一个小型但有动力的研究中，患有严重COPD症状的患者的生活质量和日常体力活动 随机研究。一般目标：该提案将提供罗伯托·本佐，医学博士，理学硕士，与保护的时间， 扩展他的初级未来NHLBI研究人员的导师，并扩大他的研究计划。具体 目的：Benzo博士计划增加他指导肺部医学和重症医学研究人员的时间。 马约诊所的护理计划，来自马约诊所生物医学科学研究生院的学生，以及 马约临床和转化科学中心学者。他还将进行机械分析， 他最近的NHLBI资助的随机研究确定了健康教练的好处， 住院治疗COPD，并扩大健康指导在另一种疾病中的有效性研究 组资历：本佐博士是马约诊所的终身副教授， 研究、出版和指导。他的K23职业发展奖，在哈佛接受流行病学培训 大学，两个随后的R 01，和多个SBIR已经发展了他的背景作为一个理想的候选人 for this application应用.他目前在马约诊所领导正念呼吸实验室，这是一个由NIH资助的实验室，致力于 以患者为导向的肺部疾病研究。环境：拟议的K24赠款将通过 马约诊所的肺部和重症监护部，在过去的2010年中在美国排名第一。 连续两年被《美国新闻与世界报道》导师计划：本佐博士目前的导师 初级教员、肺病和重症监护研究员、住院医师和研究生。若干学员 从事NHLBI研究，包括一位最近获得NHLBI K23的人。学员： 博士本佐将巩固和扩大他的辅导计划的援助，这笔赠款。该计划的 资源和声誉将吸引越来越多的合格和有前途的未来NHLBI 研究人员培训：Benzo博士将接受实质性培训，以计划、执行和分析患者- 导向研究。研究：拟议的研究将建立在本佐博士以前的工作，特别是 发表了他最近由NHLBI资助的R 01研究的发现。意义：这笔赠款将促进 发展下一代NHLBI患者为导向的研究人员，并将支持正在进行的 实施干预的研究，重点是对患者重要的事情。

PROJECT SUMMARY/ABSTRACT The overarching goal of the proposed research is to study further aspects of health coaching, an intervention that led to the first randomized evidence that health coaching reduces re-hospitalizations in chronic obstructive lung disease (COPD). The proposed study of the mechanistic effect of this intervention will lead to the creation of a theoretical framework of how the intervention works. We will further test the effect of health coaching on the quality of life and daily physical activity of a patient with severe symptoms of COPD in a small but powered randomized study. General goals: The proposal will provide Roberto Benzo, MD, MSc, with protected time to extend his mentorship of junior future NHLBI researchers and also expand his research program. Specific aims: Dr. Benzo plans to increase his time mentoring investigators from the Pulmonary Medicine and Critical Care Program at Mayo Clinic, students from the Mayo Clinic Graduate School of Biomedical Sciences, and Mayo Center for Clinical and Translational Science scholars. He will also perform the mechanistic analysis of his recent NHLBI-funded randomized study identifying the benefits of health coaching which decreases hospitalizations for COPD and expand the study of the effectiveness of health coaching in another disease group. Qualifications: Dr. Benzo is a tenured Associate Professor at Mayo Clinic, with a strong record of research, publication, and mentoring. His K23 career development award, training in epidemiology at Harvard University, two subsequent R01s, and multiple SBIRs have developed his background as an ideal candidate for this application. He currently leads the Mindful Breathing Lab at Mayo Clinic, an NIH-funded lab devoted to patient-oriented research in lung disease. Environment: The proposed K24 grant will be executed through the Division of Pulmonary and Critical Care at Mayo Clinic, which was ranked #1 in the United States in the last two consecutive years by the U.S. News & World Report. Mentoring program: Dr. Benzo presently mentors junior faculty, pulmonary and critical care fellows, resident physicians, and graduate students. Several mentees are engaged in NHLBI research, including one who was recently awarded a K23 from the NHLBI. Mentees: Dr. Benzo will solidify and expand his mentoring program with the assistance of this grant. The program's resources and reputation will attract an increasing pool of the most qualified and promising future NHLBI researchers. Training: Dr. Benzo will undertake substantive training to plan, execute, and analyze patient- oriented studies. Research: The proposed research will build on Dr. Benzo's previous work, especially the published findings of his recent NHLBI-funded R01 study. Significance: This grant will facilitate the development of the next generation of NHLBI patient-oriented researchers and will support the ongoing research implementing the intervention that focuses on what matters to patients.