Summers in Children's Research for Diverse High School Students

亚利桑那大学健康科学中心的“儿童研究之夏”（SCR），斯蒂尔儿童医院 研究中心和钻石儿童医疗中心提供每年在这5年的更新赠款提案12 来自亚利桑那州的不同弱势初中/高中学生和5名继续就读的本科生， 教育8和12周的夏季经验，分别在“动手，脑”的基础，翻译，和临床 广泛针对儿童和人类发展及相关疾病的研究。多学科项目 领导二人组包括一位国际知名的儿科医生，专门研究儿童胃肠道疾病 （分子机制和临床管理）和儿童和淋巴发育方面的国际专家 疾病和基因型-表型相关性，多样性管道研究培训和探究课程创新。 他们将与影响儿童和孕产妇健康的充满活力的研究项目互动。基于 医学院非常成功的长期联邦资助的多学科弱势多层次 学生研究项目和多样性/URM管道连续体吸引了大量合格的申请人， 在亚利桑那州周围，也是一个当地支持的部门。儿科高中学生暑期项目，SCR为过去5 多年来一直在逐步开发一个独特的核心课程，包括在线组件和扩大研究 在排雷中心使命地区的经验。全职夏季研究经验的范围从分子机制， 炎症性肠病、微生物组学和婴儿肠道疾病中的钙/磷酸盐吸收- 尼曼-皮克C病和水肿-血管发育不良综合征的蛋白质组学;先天性心脏病- 机制，并发症和管理;自闭症，残疾和康复;下一代多式联运 影像学;儿科头部创伤和药物滥用的流行病学，以及孕产妇健康和性健康领域的实地工作。 传播疾病SCR涉及经验丰富，热情的教师和近同行导师主要在儿科，但 广泛代表影响NICHD使命地区儿童的基础和临床研究。专用SCR 课程被纳入一个创新的面对面和在线调查为基础的夏季医学研究所 无知（突出未回答的问题和未质疑的答案，并加强核心内容）高中 学生和本科生，并平行于我们的医学生研究人员提供。包括高度互动 特色包括我们独特的虚拟临床研究中心，一个旨在连接NIH的基于网络的平台， CTSA/GCRC的K-12社区，使用先进的多媒体技术熟悉的青少年。Peer和Near-Peer 指导和沟通/生存/茁壮成长技能课程用于培养态度，技能和行为， 富有成效的，好奇的，有道德的科学家在合作团队中工作，沿着职业道路，与他们的 招聘教师。广泛的短期/长期形成性和总结性参与者和项目评价 记录了SCR迄今为止的成功及其来自资源的多样化、弱势、主要是URM参与者的进展， 教科文组织将继续为贫困学校提供支助，并将继续开发可复制的模式和产品，在全国范围内向其他环境推广。

“Summers in Children's Research” (SCR) at The University of Arizona Health Sciences Center, Steele Children's Research Center, and Diamond Children's Medical Center offers annually in this 5-year renewal grant proposal 12 diverse disadvantaged junior/senior high school students and 5 continuing undergraduates from Arizona an immersive educational 8- and 12- week summer experience respectively in “hands on, brain on” basic, translational, and clinical research broadly targeting childhood and human development and associated disorders. The multidisciplinary project leadership duo includes an internationally renowned pediatrician specialized in children's gastrointestinal disorders (molecular mechanisms and clinical management) and an international expert in childhood and developmental lymphatic disorders and genotype-phenotype correlations, diversity pipeline research training, and inquiry curriculum innovation. They will together interact with vibrant research programs impacting children's and maternal health. Based on the College of Medicine's highly successful longstanding federally funded multidisciplinary disadvantaged multilevel student research programs and diversity/URM pipeline continuum drawing large numbers of qualified applicants from around Arizona and also a locally supported Dept. of Pediatrics high school student summer program, SCR for the past 5 years has been stepwise developing a distinctive core curriculum including online components and expanded research experiences in NICHD mission areas. Full-time summer research experiences range from molecular mechanisms of calcium/phosphate absorption in inflammatory bowel disease, microbiomics, and infant diarrheal disorders to genomics- proteomics of Niemann-Pick C disease and lymphedema-angiodysplasia syndromes; congenital heart disease – mechanisms, complications, and management; autism, disabilities and rehabilitation; next generation multimodal imaging; epidemiology of pediatric head trauma and substance abuse, and field work in maternal health and sexually transmitted diseases. SCR involves experienced, enthusiastic faculty and near-peer mentors primarily in Pediatrics but broadly representing basic and clinical research impacting children in NICHD mission areas. The specialized SCR curriculum is incorporated into an innovative face-to-face and online inquiry-based Summer Institute on Medical Ignorance (highlighting Unanswered Questions and Unquestioned Answers and reinforcing core content) for high school students and undergraduates and paralleling our medical student researcher offering. Included are highly interactive features such as our unique Virtual Clinical Research Center/Questionarium, a web-based platform designed to link NIH, CTSAs/GCRCs to the K-12 community, using advanced multimedia technology familiar to teenagers. Peer and near-peer mentoring and communication/surviving/thriving skill sessions are used to develop attitudes, skills, and behaviors of fruitful, curious, and ethical scientists working in collaborative teams along career pathways in concert with their recruiting teachers. Extensive short-term/long-term formative and summative participant and project evaluation documents SCR's success to date and the progress of its diverse, disadvantaged, largely URM participants from resource- poor schools and will be continued to develop replicable models and products to disseminate nationally to other settings.