Principles of olfactory reward processing in the human brain
Principles of olfactory reward processing in the human brain
批准号:
10202273
负责人:
Christina Maria Zelano
金额:
$48.1万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
未结题
起止时间:
2016-09-01 至 2026-08-31
关键词:
AddressAnimal BehaviorAnimalsAnteriorArchitectureBehaviorBehavioralBiologicalBrainComplexCuesDataDecision MakingDesire for foodDetectionDevelopmentDissociationDopamineEatingEating DisordersEnvironmentEventFoodFood ProcessingFoundationsFunctional Magnetic Resonance ImagingFundingFutureGoalsHumanHungerImageImpairmentIndividualKnowledgeLateralLeadLearningMate SelectionsMemoryMethodsMidbrain structureModalityModelingMotivationNetwork-basedNeuraxisNeuronsOdorsOlfactory CortexOutcomePatternPerceptionPlayPositioning AttributePropertyProtocols documentationPsychological reinforcementPsychometricsPsychophysicsResearchRewardsRoleSatiationSchizophreniaSensorySignal TransductionSiteSleep DeprivationSmell PerceptionStrawberriesTechniquesTestingTimeTranscranial magnetic stimulationUpdateWorkaddictionbaseclinically relevantdiagnostic biomarkerexpectationexperimental studyfield studyinnovationinsightlearned behaviorneural correlateneuroimagingneuromechanismneuropsychiatric disorderneuropsychiatrynoninvasive brain stimulationnovelnovel diagnosticsnovel therapeutic interventionpiriform cortexreinforcerrelating to nervous systemresponsereward processingtheories
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
A crucial function of the central nervous system is to bias behavior toward events and outcomes that hold
relevance for survival. It is well recognized that odors have a strong effect on animal behavior, as they guide
food search, maternal bonding, and mate selection. Even though humans do not consider olfaction to be a
dominant sense, humans are similarly swayed by the rewarding properties of odors. With recent developments
in the pattern-based analysis of functional magnetic resonance imaging (fMRI) data and non-invasive brain
stimulation techniques, we are now in a position to explore the neural mechanisms of olfactory reward in
humans. During the previous funding cycle, we gained key insights into how odor rewards are represented in
orbitofrontal cortex (OFC), and how the dopaminergic midbrain may support these representations. The
objective of the current renewal application is to capitalize on these novel methods in order to address new
questions arising from these initial findings about the neural mechanisms of odor-guided behavior in humans.
Specifically, we will use OFC-targeted transcranial magnetic stimulation (TMS) and novel behavioral tasks that
involve food odors as rewards to reveal the specific contribution of different OFC networks to decision making.
Moreover, the proposed studies will combine network-based TMS with pattern-based fMRI to elucidate the
neural mechanisms that drive learning about the identity of future odor rewards. Complementary studies will
examine how one’s motivational state modulates perceptional and neural responses to food odors, such that
they can aid the detection of biologically relevant rewards in the environment. Together the experiments
proposed in this project will fundamentally extend our understanding of olfactory reward processing in the
human brain at the functional and mechanistic level, with implications for neuroscientific research on learning,
memory, and behavior in general. Moreover, the findings from this work can lead to a better understanding of
the behavioral deficits described in a variety of neuropsychiatric disorders, including Schizophrenia, eating
disorders, and addiction, and may ultimately provide insights into the development of novel diagnostic and
therapeutic approaches.
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会议论文
Characterizing the primary olfactory subregions of the human amygdala
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批准号:10594449
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项目类别:
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资助金额:$43.28万
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财政年份:2021
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负责人:Christina Maria Zelano
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依托单位:
The function of respiratory-linked local field potential oscillations in human olfactory and limbic brain regions
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批准号:9913507
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项目类别:
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资助金额:$41.65万
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财政年份:2018
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负责人:Christina Maria Zelano
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依托单位:
The function of respiratory-linked local field potential oscillations in human olfactory and limbic brain regions
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批准号:10391438
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项目类别:
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资助金额:$40.09万
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财政年份:2018
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负责人:Christina Maria Zelano
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依托单位:
Principles of olfactory reward processing in the human brain
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批准号:10410495
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项目类别:
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资助金额:$48.1万
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财政年份:2016
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负责人:Christina Maria Zelano
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依托单位:
Attention-dependent neural oscillations in the human olfactory system
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批准号:8425886
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项目类别:
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资助金额:$9.63万
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财政年份:2012
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负责人:Christina Maria Zelano
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依托单位:
Attention-dependent neural oscillations in the human olfactory system
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批准号:9249540
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项目类别:
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资助金额:$23.92万
-
财政年份:2012
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负责人:Christina Maria Zelano
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依托单位:
The role of the thalamus in human olfactory processing
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批准号:8246498
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项目类别:
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资助金额:$4.11万
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财政年份:2010
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负责人:Christina Maria Zelano
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依托单位:
The role of the thalamus in human olfactory processing
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批准号:8003504
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项目类别:
-
资助金额:$5.22万
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财政年份:2010
-
负责人:Christina Maria Zelano
-
依托单位:
The role of the thalamus in human olfactory processing
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批准号:8054772
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项目类别:
-
资助金额:$5.47万
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财政年份:2010
-
负责人:Christina Maria Zelano
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依托单位:
海外基金