Controlled Exposure Informatics/Modeling Facility Core

摘要：受控暴露和信息/建模因素核心 精密环境健康（PEH）研究的重点是阐明暴露如何导致不良反应。 结果。CEIM核心有两个单位来支持PEH研究，一个提供设施和专业知识 第一个用于受控曝光实验，第二个用于信息学和系统计算建模， 曝光和影响。控制暴露（CE）单元提供了暴露健康和 患病的个体和动物到特定的、受控的条件下进行生物标志物的发现和验证。的 信息学/建模股为大规模环境和生物数据提供计算工具 分析以及环境和生物过程和相互作用的机械系统建模。 因此，核心为构建和实施PEH研究的关键组成部分提供了强大的工具。 该中心为CEED研究人员提供从人体收集实时暴露数据的能力， 受试者和实验动物在受控环境中使用模拟环境的限定气氛， 或职业暴露，同时限制混杂因素。环境与发展股支持关于以下方面相互作用的研究： 化学品暴露和变量，如温度，湿度，运动，心理社会压力，和前 现有疾病（例如，哮喘）。人类和啮齿动物的生理和行为反应可以是 在人类控制暴露设施或 动物暴露设施。这两个项目都采用了最先进的污染物生成和监测系统。的 I/M Unit提供信息学专业知识和计算支持， 异构数据集从多个来源，使用新兴的科学，工程和技术。这些 数据集包括来自公共和专有来源的健康结果和与医疗保险有关的信息。 I/M股提供资源，以应对因数据量大而带来的许多挑战， 在曝光科学和生物医学领域中使用的“新来源”迅速变得可用。它 还支持CEED研究人员需要对“来源到剂量到暴露”的机制进行建模， 效果”的过程。I/M Unit通过提供对高级数据集成和分析的访问来满足这些需求 和系统建模工具，可用于估计暴露和剂量，并及早识别或预测 生物反应，目的是设计干预和预防战略， 疾病该股是CEED重点关注人口和社区的一个组成部分，因为它可以为决策提供信息 关于替代预防和补救策略，从我们的社区研究伙伴关系产生。 此外，I/M股还通过计算工具（如交互式可视化）向CoEC提供支持 以及与接触和结果有关的绘图）， 成员、组织和监管机构。

ABSTRACT: CONTROLLED EXPOSURE AND INFORMATICS/MODELING FACILITY CORE Precision Environmental Health (PEH) research is anchored in elucidating how exposure leads to adverse outcomes. The CEIM Core has two Units to support PEH research, one that provides facilities and expertise for controlled exposures experiments and a second for informatics and systems computational modeling of exposures and effects. The Controlled Exposure (CE) Unit provides platforms for exposing healthy and diseased individuals and animals to specific, controlled conditions for biomarker discovery and validation. The Informatics/Modeling (I/M) Unit provides computational tools for large-scale environmental and biological data analytics as well as mechanistic-systems modeling of environmental and biological processes and interactions. The Core thus provides powerful tools for building and implementing a crucial component of PEH research. The CE Unit provides CEED investigators with the capability of collecting real-time exposure data from human subjects and experimental animals in a controlled setting using defined atmospheres that mimic environmental or occupational exposures, while limiting confounders. The CE Unit supports studies on interactions between chemical exposures and variables such as temperature, humidity, exercise, psychosocial stress, and pre- existing disease (e.g., asthma). Physiological and behavioral responses of humans and rodents can be measured simultaneously to the exposure administered in either the human Controlled Exposure Facility or the Animal Exposure Facility. State-of-the-art pollutant generation and monitoring systems are used for both. The I/M Unit provides informatics expertise and computational support for the integrative analysis of large heterogeneous data sets from multiple sources, using emerging science, engineering, and technology. These data sets include health outcomes and exposure-relevant information from both public and proprietary sources. The I/M Unit provides resources to address the many challenges presented by the volume of data that are rapidly becoming available from “new sources” being used in exposure science and the biomedical fields. It also supports CEED investigators’ need to model mechanisms involved in the “source to dose to exposure to effect” process. The I/M Unit fills these needs by providing access to high-level data integration and analytics and systems modeling tools that can be used to estimate exposure and dose, and identify or predict early biological responses, for the purpose of designing intervention and prevention strategies that modify risk of disease. The Unit is integral to CEED’s focus on populations and communities, as it can inform decisions about alternative prevention and remediation strategies that arise from our community-researcher partnerships. Additionally, the I/M Unit provides support to CoEC through computational tools (e.g. interactive visualization and mapping relevant to exposures and outcomes) that facilitate interactions between scientists, community members and organizations, and regulators.