Bioinformatics, Biostatistics

生物信息学和计算毒物学股在这些领域提供广泛的咨询 基因组学、蛋白质组学、代谢组学、细胞学、组织造口学、生理学和综合生物信息学。 具体方面包括数据管理、集成、迁移；可视化和分析；生物网络 建模和分析；基于生理学的毒物动力学建模；基于生物学的剂量-反应 (毒物动力学)建模；机理模型优化；以及敏感性和不确定性分析。 具体地说，该单位的研究人员帮助调查人员了解系统的生物反应 级别，说明不同的“组学”组件、相互作用和功能状态。 这些核心单元位于EOHSI大楼的三楼，提供最先进的设施 用于环境和生物系统的建模和信息学，致力于开发和 改进进行机械化健康风险研究的方法。除了支持 该中心的努力、该股的建模和数据分析工作还支持：(1)美国环保局资助 环境生物信息学和计算毒理学中心(EbCTC)，(2)美国环保局资助 暴露和风险建模中心(GERM)，(3)国家儿童研究，(4)和臭氧 研究中心，由新泽西州环境保护部(NJDEP)资助。

The Bioinformatics and Computational Toxicology Unit provides a broad range of consultations in the areas of genomics, proteomics, metabonomics, cytomics, histomics, physiomics, and integrative bioinformatics. Specific aspects include data management, integration, migration; visualization and analysis; bionetwork modeling and analysis; physiologically based toxicokinetic modeling; biologically based dose-response (toxicodynamic) modeling; mechanistic model optimization; as well as sensitivity and uncertainty analysis. Specifically, researchers within this Unit help investigators understand biological responses at the systems level, accounting for different "omics" components, interactions, and functional states. These Core Unit, located on the third floor of the in the EOHSI building, provides state-of-the-art facilities for modeling and informatics of environmental and biological systems and is dedicated to the development and improvement of methods for performing mechanistically-based health risk studies. In addition to supporting the efforts of the Center, the modeling and data analysis efforts of the this Unit also support: (1) the USEPAfunded environmental bioinformatics and Computational Toxicology Center (ebCTC), (2) the USEPA-funded Center for Exposure and Risk Modeling (GERM), (3) the National Children's Study, (4) and the Ozone Research Center, funded by the New Jersey Department of Environmental Protection (NJDEP).