CORE--EXPOSURE AND DOSIMETRY MODELING FACILITY

核心——暴露和剂量测定建模设施

• 批准号: 6587355
• 负责人: PANOS GEORGOPOULOS
• 金额: $ 17.41万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-15 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6587355
• 关键词: biomedical facility; environmental toxicology; mathematical model; model design /development; toxicant interaction

The Exposure and Dosimetry Modeling Facility Core is directed by Dr. Georgopoulos. Workstations and server clusters that service this facility are located within the EOHSI and the hardware and software used are facilities of the EOHSI Computational Chemodynamics Laboratory (CCL). The aims of this core are to adapt, improve, and test methods for (1) estimating toxic exposures, including pharmacokinetic modeling of target tissue exposure, (2) assessing biomarkers of exposure, and (3) estimating transport, concentration, and deposition of chemicals, including estimation of inter- and intra-individual variation. The support services offered are (1) assistance with data analysis and (2) assistance with computer modeling. The only tangible evidence of past performance of this Core is contained in four examples, which are critiqued below. Future directions are slated for continued efforts in developing distributed parameter models, and new efforts to incorporate random effects modeling and create food-web models.

曝光和剂量学建模设施核心由 博士乔戈普洛斯为该设施提供服务的工作站和服务器群集 位于EOHSI内，使用的硬件和软件是设施 EOHSI计算化学动力学实验室（CCL） 这个核心的目的是适应，改进和测试方法， (1)估计毒性暴露，包括靶点的药代动力学建模 组织暴露，（2）评估暴露的生物标志物，以及（3）估计 化学品的运输、集中和沉积，包括 个体间和个体内变异。所提供的支持服务包括 (1)协助数据分析和（2）协助计算机建模。 该核心过去性能的唯一有形证据包含在 四个例子，这是批评下面。 未来的方向是继续努力开发分布式 参数模型，以及将随机效应模型和 创建食物网模型。