Research Training: Mental Health Behavior Genetics

项目摘要 该提案寻求通过机构培训赠款继续支持一项学前和学前教育培训方案， 博士后研究员，他们将从事专注于遗传对心理健康影响的研究事业 行为遗传学来自行为遗传学研究所（IBG）和合作单位的教师， 杰出和活跃的研究，IBG科学家正在积极寻求资金充足的遗传研究， 影响大脑功能和可塑性，心理，认知和大脑发育直接相关， 心理健康和精神疾病。生物统计学、统计学和数量遗传学的应用 技术，以及生物信息学、全基因组分析和下一代测序， 表观遗传学，正在提供真实的知识进步。神经化学，药理学，生理学，和 分子遗传学研究，提供了一个了解基因功能与行为。自我们上次 应用，我们增加了一个主要的承诺，功能和结构脑成像作为一种研究工具 并相应地扩大了我们的师资队伍和培训计划。我们的研究和培训包括使用 大规模的合作研究正在积累DNA储存库和丰富的表型数据集 心理健康的研究。其中包括青少年大脑认知发展（ABCD）研究， 我们的培训教师是双胞胎研究组成部分的PI，精神病学遗传学联盟，英国 生物银行和GSCAN，一项超过100万病例的全基因组研究。IBG设施可用于基因 功能和表达研究，以及行为，生物化学和神经生理学研究，我们正在 积极开展动物模型研究，以了解遗传变异的功能意义， 与人类群体中的表型相关。反映培训需求的扩大，特别是遗传学方面的培训需求 在ABCD背景下应用的专业知识，脑成像，转化研究和“大数据”研究，基金 要求支持6名博士前和2名博士后学员。学员通常会得到支持， 到3年。博士预科学员从合作学术单位获得博士学位和证书 在行为遗传学上。培训计划的学术要求包括行为遗传学培训， 定量和生物统计遗传学，理论和计算机统计学，分子遗传学， 神经科学，生物信息学和基因组学，负责任地进行研究的强制性培训，以及 行为、脑成像和临床表型课程。附加要求根据 学位授予学术单位研究是培训的一个组成部分。博士后学员也追求一个 一个正式的计划，强调个人的研究以及在分子和定量能力 行为遗传学为心理健康研究职业做准备的其他活动包括： 学生和/或技术人员，主持研讨会发言人和会议组织，客座演讲， 每周的期刊俱乐部，赠款写作，以及个人专业计划的发展。

PROJECT SUMMARY This proposal seeks continued support, via an institutional training grant, for a training program for pre and postdoctoral fellows who will pursue research careers that focus on genetic influences on mental health behavior genetics. The faculty, from the Institute for Behavioral Genetics (IBG) and collaborating units, is distinguished and active in research, and IBG scientists are actively pursuing well-funded studies of genetic influences on brain function and plasticity, psychological, cognitive and brain development directly relevant to mental health, and psychiatric disorders. The application of biometrical, statistical, and quantitative genetic techniques, together with bioinformatics, genome-wide analyses and next generation sequencing, and epigenetics, is providing real advances in knowledge. Neuro-chemical, -pharmacological, -physiological, and molecular genetic studies, are providing an understanding of gene function related to behavior. Since our last application, we have added a major commitment to functional and structural brain imaging as a research tool and have expanded our faculty and training program accordingly. Our research and training include the use of large scale collaborative studies that are amassing DNA repositories and rich phenotypic data sets available for studies of mental health. These include the Adolescent Brain Cognitive Development (ABCD) study, for which our training faculty are PIs of the twin study component, the Psychiatric Genetics Consortium, the UK Biobank, and GSCAN, a genome wide study of over 1 million cases. IBG facilities are available for gene function and expression studies, and behavioral, biochemical, and neurophysiological studies, and we are actively pursuing animal model studies of the functional implications of genetic variation robustly associated with phenotypes in the human population. To reflect the expanded need for training, particularly for genetics expertise applied in the context of ABCD, brain imaging, translational research, and `big data' studies, funds are requested to support 6 pre-doctoral and 2 postdoctoral trainees. Trainees will typically be supported for up to 3 years. Pre-doctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, neuroscience, bioinformatics and genomics, mandatory training in the responsible conduct of research, and courses on behavioral, brain imaging, and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in mental health include: supervision of students and/or technicians, hosting of seminar speakers and conference organization, guest lecturing, a weekly journal club, grant writing, and the development of individual professional plans.