Research Training: Mental Health Behavior Genetics

项目总结 这项提案寻求通过机构培训赠款继续支持预科和预科教育培训方案。 将从事基因对心理健康影响的研究的博士后研究员 行为遗传学。来自行为遗传学研究所(IBG)和合作单位的教职员工是 杰出和活跃的研究，IBG的科学家正在积极开展资金充足的遗传学研究 对大脑功能和可塑性、心理、认知和大脑发育的影响直接相关 精神健康和精神障碍。生物计量学、统计学和数量遗传学的应用 技术，连同生物信息学、全基因组分析和下一代测序，以及 表观遗传学，正在提供真正的知识进步。神经化学，-药理，-生理，和 分子遗传学研究提供了对与行为相关的基因功能的理解。自从我们上一次 作为一种研究工具，我们增加了对功能和结构脑成像的主要承诺 并相应地扩大了我们的师资队伍和培训计划。我们的研究和培训包括使用 正在积累DNA存储库和丰富的表型数据集的大规模协作研究 用于心理健康研究。这些研究包括青少年大脑认知发展(ABCD)研究， 我们的培训人员是英国精神病学遗传学协会双胞胎研究部门的PI Biobank和GSCAN，这是一项对100多万例患者进行的全基因组研究。可为基因提供IBG设备 功能和表达研究，以及行为、生化和神经生理学研究，我们是 积极开展基因变异的功能影响的动物模型研究 与人类群体中的表型有关。以反映培训需求的扩大，特别是对遗传学的培训 在ABCD、脑成像、翻译研究和大数据研究中应用的专业知识，基金 要求支持6名博士后和2名博士后实习生。受训人员通常将获得UP支持 到3年。博士前实习生从合作的学术单位获得博士学位并获得认证 在行为遗传学方面。培训计划的学术要求包括行为遗传学方面的培训， 定量和生物计量遗传学、理论和计算机统计学、分子遗传学、 神经科学、生物信息学和基因组学，负责任的研究行为方面的强制性培训，以及 关于行为、脑成像和临床表型的课程。附加要求根据 学位授予学术单位。研究是培训不可或缺的一部分。博士后实习生还将攻读 强调个人研究以及在分子和定量方面的能力的正式计划 行为遗传学。为心理健康研究事业做准备的其他活动包括：监督 学生和/或技术人员，主持研讨会演讲者和会议组织，客座演讲，a 周刊俱乐部，拨款写作，以及个人职业计划的发展。

PROJECT SUMMARY This proposal seeks continued support, via an institutional training grant, for a training program for pre and postdoctoral fellows who will pursue research careers that focus on genetic influences on mental health behavior genetics. The faculty, from the Institute for Behavioral Genetics (IBG) and collaborating units, is distinguished and active in research, and IBG scientists are actively pursuing well-funded studies of genetic influences on brain function and plasticity, psychological, cognitive and brain development directly relevant to mental health, and psychiatric disorders. The application of biometrical, statistical, and quantitative genetic techniques, together with bioinformatics, genome-wide analyses and next generation sequencing, and epigenetics, is providing real advances in knowledge. Neuro-chemical, -pharmacological, -physiological, and molecular genetic studies, are providing an understanding of gene function related to behavior. Since our last application, we have added a major commitment to functional and structural brain imaging as a research tool and have expanded our faculty and training program accordingly. Our research and training include the use of large scale collaborative studies that are amassing DNA repositories and rich phenotypic data sets available for studies of mental health. These include the Adolescent Brain Cognitive Development (ABCD) study, for which our training faculty are PIs of the twin study component, the Psychiatric Genetics Consortium, the UK Biobank, and GSCAN, a genome wide study of over 1 million cases. IBG facilities are available for gene function and expression studies, and behavioral, biochemical, and neurophysiological studies, and we are actively pursuing animal model studies of the functional implications of genetic variation robustly associated with phenotypes in the human population. To reflect the expanded need for training, particularly for genetics expertise applied in the context of ABCD, brain imaging, translational research, and `big data' studies, funds are requested to support 6 pre-doctoral and 2 postdoctoral trainees. Trainees will typically be supported for up to 3 years. Pre-doctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, neuroscience, bioinformatics and genomics, mandatory training in the responsible conduct of research, and courses on behavioral, brain imaging, and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in mental health include: supervision of students and/or technicians, hosting of seminar speakers and conference organization, guest lecturing, a weekly journal club, grant writing, and the development of individual professional plans.