A Twin Study of Adolescent Alcohol and Drug Use Development: Leveraging Intensive Longitudinal Assessments

摘要 这是对PA-18-591的回应：对现有NIH赠款和合作的行政补充 协议（家长管理支持临床试验可选）。这个父项目是密集课程的一部分， 建立纵向健康行为网络（ILHBN），以合作研究影响 个人日常生活中的动态健康行为，使用密集的纵向数据（ILD）收集和新的 分析方法该网络包括七个U 01项目和一个U24研究协调中心 （RCC）。这个特定的项目利用ILD在遗传信息设计，以了解发展， 在COVID-19大流行背景下的影响、流动性和药物使用。有证据表明， COVID大流行导致抑郁情绪和焦虑增加。这些，反过来， 对其他健康行为的影响，如物质使用行为。使用密集的纵向数据，我们 将评估个人如何自我报告情感动力和流动模式的性质和病因 随着时间的推移而变化，使用基于电话的位置数据来推断个人的活动空间（ 日常活动）以及当地的新冠肺炎情况（例如，案例计数、封锁政策） COVID.我们将测试当地新冠疫情的变化是否相互关联， 影响力，流动性和物质使用的变化。来自母项目的数据将与ILHBN共享 研究协调中心，以促进其他ILHBN研究的科学努力。

ABSTRACT This is a response to PA-18-591: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional). This parent project is part of the Intensive Longitudinal Health Behaviors Network (ILHBN) established to collaboratively study factors that influence dynamic health behaviors in individuals’ daily lives, using intensive longitudinal data (ILD) collection and novel analytic methods. The network includes seven U01 projects and one U24 Research Coordinating Center (RCC). This specific project leverages ILD in a genetically informative design to understand the development of affect, mobility, and drug use in the context of the COVID-19 pandemic. Evidence suggests that the experience of the COVID pandemic has caused increases in depressed mood and anxiety. These, in turn, have implications for other health behaviors, such as substance use behaviors. Using intensive longitudinal data, we will evaluate the nature and etiology of how individuals’ self-report affective dynamics and mobility patterns vary over time, using phone-based location data to infer individuals’ activity space (typical area traveled for routine everyday activities) as well as local covid conditions (e.g., case counts, lockdown policy) related to COVID. We will test whether changes in local covid conditions are associated with each other and with changes in affect, mobility, and substance use. Data from the parent project will be shared with the ILHBN Research Coordinating Center to facilitate scientific efforts in other ILHBN studies.