A Twin Study of Adolescent Alcohol and Drug Use Development: Leveraging Intensive Longitudinal Assessments

摘要 这是对PA-18-591的回应：对现有NIH拨款和合作社的行政补充 协议(家长药物补充临床试验可选)。这个父项目是密集的 建立纵向健康行为网络(ILHBN)，共同研究影响因素 个人日常生活中的动态健康行为，使用密集的纵向数据(ILD)收集和 分析方法。该网络包括7个U01项目和1个U24研究协调中心 (RCC)。这个特定的项目利用ILD在基因信息丰富的设计中了解 新冠肺炎大流行背景下的情感、流动性和药物使用。有证据表明，这种经历 COVID大流行的流行导致抑郁情绪和焦虑增加。这些，反过来，又有 对其他健康行为的影响，如物质使用行为。使用密集的纵向数据，我们 我将评估个人自我报告情感动态和流动模式的性质和病因 随着时间的推移而变化，使用基于手机的位置数据来推断个人的活动空间(典型的旅行区域 日常活动)以及与以下相关的当地围栏情况(例如，病例计数、封锁政策) 科维德。我们将测试当地气候条件的变化是否相互关联，并与 影响、机动性和物质使用的变化。来自父项目的数据将与ILHBN共享 研究协调中心，以促进ILHBN其他研究的科学努力。

ABSTRACT This is a response to PA-18-591: Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional). This parent project is part of the Intensive Longitudinal Health Behaviors Network (ILHBN) established to collaboratively study factors that influence dynamic health behaviors in individuals’ daily lives, using intensive longitudinal data (ILD) collection and novel analytic methods. The network includes seven U01 projects and one U24 Research Coordinating Center (RCC). This specific project leverages ILD in a genetically informative design to understand the development of affect, mobility, and drug use in the context of the COVID-19 pandemic. Evidence suggests that the experience of the COVID pandemic has caused increases in depressed mood and anxiety. These, in turn, have implications for other health behaviors, such as substance use behaviors. Using intensive longitudinal data, we will evaluate the nature and etiology of how individuals’ self-report affective dynamics and mobility patterns vary over time, using phone-based location data to infer individuals’ activity space (typical area traveled for routine everyday activities) as well as local covid conditions (e.g., case counts, lockdown policy) related to COVID. We will test whether changes in local covid conditions are associated with each other and with changes in affect, mobility, and substance use. Data from the parent project will be shared with the ILHBN Research Coordinating Center to facilitate scientific efforts in other ILHBN studies.