Longitudinal Effects of Sleep Problems on Cognition

睡眠问题对认知的纵向影响

• 批准号: 7144007
• 负责人: Naomi P. Friedman
• 金额: $ 7.45万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7144007
• 关键词: attention; clinical research; cognition; disease /disorder etiology; environment; executive function; family genetics; functional ability; gene environment interaction; genetic models; genetic susceptibility; growth /development; human data; intelligence; longitudinal human study; pathologic process; sleep; sleep deprivation; sleep disorders; statistics /biometry; twin /multiplet

DESCRIPTION (provided by applicant): Sleep-related cognitive problems can result in accidents, deficient job and work performance, poor decision making, and other serious problems. Previous research supports the general conclusion that sleep problems influence cognitive functioning, but evidence also indicates sleep problems affect some cognitive functions more than others. However, specific patterns of impairments are inconsistent across studies, possibly because of less than optimal individual cognitive measures. Moreover, the field lacks a systematic analysis of developmental patterns of general and specific Sleep problems and their cognitive covariates and sequelae. The specific aims of this project are to (1) identify developmental patterns in sleep problems; (2) specify the etiology of sleep problems, including genetic and environmental contributions to stability and change; and (3) determine the effect of developmental and concurrent sleep problems on different cognitive functions. These goals will be addressed through application of statistical techniques, not previously applied to these issues, to existing longitudinal data from a large-scale study of 462 twin pairs examined from infancy through early adulthood. Specifically, we will use latent class growth curve models of parent-rated sleep problems from ages 4 to 16 to explore the development of sleep problems and identify different patterns (e.g., persistent vs. transient). We will then apply genetic models of these developmental patterns as well as problems at individual time points to specify the etiology of these problems. Finally, we will examine the cognitive outcomes of developmental problems as well as recent self-ratings of sleep habits, using latent- variable cognitive ability outcome measures of multiple separable executive functions and other cognitive abilities. We will also examine the effect of sleep problems on teacher-rated attention and thought problems throughout development. These proposed analyses will result in more comprehensive and powerful models of sleep problems and cognitive function.

描述（由申请人提供）：睡眠相关的认知问题可能导致事故，工作和工作表现不佳，决策能力差和其他严重问题。以前的研究支持睡眠问题影响认知功能的一般结论，但证据也表明睡眠问题对某些认知功能的影响比其他人更大。然而，具体的损伤模式是不一致的研究，可能是因为低于最佳的个人认知措施。此外，该领域缺乏对一般和特定睡眠问题及其认知协变量和后遗症的发展模式的系统分析。该项目的具体目标是（1）确定睡眠问题的发展模式;（2）详细说明睡眠问题的病因，包括遗传和环境对稳定性和变化的贡献;（3）确定发展和并发睡眠问题对不同认知功能的影响。这些目标将通过应用统计技术来解决，以前不适用于这些问题，现有的纵向数据从一个大规模的研究462双胞胎对检查从婴儿期到成年早期。具体来说，我们将使用4至16岁父母评定的睡眠问题的潜在类增长曲线模型来探索睡眠问题的发展并识别不同的模式（例如，持久对瞬时）。然后，我们将应用这些发展模式的遗传模型以及在个别时间点的问题，以指定这些问题的病因。最后，我们将使用多个可分离的执行功能和其他认知能力的潜在变量认知能力结果测量来检查发育问题的认知结果以及最近的睡眠习惯自我评级。我们还将研究睡眠问题对教师评定的注意力和整个发展过程中的思维问题的影响。这些拟议的分析将产生更全面和更强大的睡眠问题和认知功能模型。