The social neurobiology of vocal production and perception

声音产生和感知的社会神经生物学

基本信息

批准号：
10415071
负责人：
Asif Ghazanfar
金额：
$ 38.77万
依托单位：
PRINCETON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10415071
关键词：
Adult Aggressive behavior Amygdaloid structure Animal Behavior Animal Model Anterior Area Auditory Basal Ganglia Behavior Behavioral Biological Models Brain imaging Callithrix Caring Communication Complex Computer Models Data Development Disease Electrophysiology (science)Evolution Generations Glean Human Hypothalamic structure Image Imaging technology Impairment Individual Interruption Investigation Knowledge Language Lead Link Medial Mental disorders Methods Modeling Monitor Monkeys Motor Motor Activity Neural Pathways Neurobiology Output Parkinson Disease Patients Perception Play Positioning Attribute Primates Probability Production Reproduction Role Semantics Signal Transduction Social Behavior Social Functioning Social Interaction Structure Testing Time Ultrasonography Vertebrates Work autism spectrum disorder base behavioral impairment cingulate cortex cognitive function feeding imaging modality insight microstimulation midbrain central gray substance neuroimaging neuromechanism neurophysiology novel predictive modeling relating to nervous system social social deficits sound statistics syntax temporal measurement vocalization

项目摘要

PROJECT SUMMARY The functions of vocal communication occur not just through a shared understanding of the semantics and syntax of a common language, but also through a temporal coordination of behavior between the two individuals as well. This temporal coordination emerges spontaneously in any given conversation and is known as vocal turn-taking. Given the central importance of vocal turn-taking in everyday human social interactions, it is natural to ask what are its neural bases. Understanding the neural bases of vocal turn-taking may provide insights into not only the basic mechanisms of a ubiquitous form of social interaction but may also illuminate the mechanisms that go awry in disorders that include social dysfunction. In several psychiatric disorders, like Parkinson's disease and autism, there are problems with vocal turn-taking that ultimately may lead to a lack of social connectedness. What is needed is some basic knowledge of the neural mechanisms of vocal production and perception, and their coordination during turn-taking, before we can develop a framework for investigating the underlying neural causes of behavioral impairments that limit patients' capacities to become communicatively-engaged with other individuals. We will quantitatively characterize turn-taking behavior in an animal model system and investigate its neurobiology. Specifically, we will investigate during vocal production, perception and real-time turn-taking the roles played by a medial frontal cortical structure—the anterior cingulate cortex (ACC)—and a subcortical network known as the “social behavior network” (SBN). A handful of studies established the ACC's important role in vocal production, but none investigated ACC's role in vocal perception. The SBN is a set of interconnected subcortical areas that are common across all vertebrates and that regulates a range of social behaviors (feeding, aggression, reproduction and parental care); it includes structures such as the basal ganglia, amygdala, periaqueductal gray area and hypothalamus (among other regions). Its putative role in communication is unknown but many of its nodes overlap with those that are involved in vocal production. Our aims will 1) develop a computational model of vocal turn-taking to generate specific neural hypotheses; 2) use new imaging technology to investigate the large-scale network underlying vocal production and perception; and 3) use microstimulation and electrophysiology to directly test hypotheses gleaned from the model and imaging data.

项目摘要声音交流的功能不仅是通过对语义的共同理解和通用语言的语法，但也是通过暂时协调两者之间的行为个人也是如此。这种暂时的协调在任何给定的对话中都会出现，并且众所周知作为人声转。鉴于每天在人类社交互动中发声的重要性很自然地问它的神经基础是什么。了解声音转弯的神经基础可能会提供深入了解社交互动的普遍形式的基本机制，还可以阐明包括社会功能障碍在内的疾病中出现问题的机制。在几种精神疾病中帕金森氏病和自闭症，发声转弯存在问题，最终可能导致缺乏社会联系。需要的是对声带的神经机制的一些基本知识和感知及其在转弯期间的协调行为障碍的基本神经原因，限制患者的能力与其他人进行沟通。我们将定量地表征动物模型系统中的转弯行为，并研究其神经生物学。特别是，我们将在声音产生，感知和实时转折期间进行调查中位额叶皮质结构（前扣带回皮层（ACC））和皮层皮层扮演的角色网络称为“社会行为网络”（SBN）。少数研究确立了ACC重要的在声带生产中的作用，但没有一个研究ACC在人声感知中的作用。 SBN是一组在所有脊椎动物中常见的互连皮质区域，并调节一系列社会行为（进食，积极，繁殖和父母护理）；它包括基本的结构神经节，杏仁核，围栏灰色区域和下丘脑（除其他区域）。它在沟通尚不清楚，但其许多节点与参与声乐产生的节点重叠。我们的 AIMS将1）开发出发声的计算模型，以产生特定的神经假设； 2）使用新的成像技术研究了声音产生和感知的大规模网络；和 3）使用微刺激和电生理学直接检验从模型和成像中收集的假设数据。

项目成果

期刊论文数量（39）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Domestication Phenotype Linked to Vocal Behavior in Marmoset Monkeys.

DOI：
10.1016/j.cub.2020.09.049
发表时间：
2020-12-21
期刊：
Current biology : CB
影响因子：
0
作者：
Ghazanfar AA;Kelly LM;Takahashi DY;Winters S;Terrett R;Higham JP
通讯作者：
Higham JP

Facial muscle coordination in monkeys during rhythmic facial expressions and ingestive movements.

猴子在有节奏的面部表情和摄取运动期间的面部肌肉协调。

DOI：
10.1523/jneurosci.6136-11.2012
发表时间：
2012
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Shepherd,StephenV;Lanzilotto,Marco;Ghazanfar,AsifA
通讯作者：
Ghazanfar,AsifA

Cineradiography of monkey lip-smacking reveals putative precursors of speech dynamics.