CRCNS: Optimization of closed-loop control of gamma oscillations
CRCNS:伽马振荡闭环控制的优化
基本信息
- 批准号:10636642
- 负责人:
- 金额:$ 28.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-26 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AccountingAddressAffectAlgorithmsAmygdaloid structureAnatomyBehaviorBehavioralBiophysicsBrainBrain regionCell NucleusCellsCollaborationsCommunicationDetectionEmotionalFrequenciesGeneticGoalsImplantIndividualIndividual DifferencesInstructionInterneuronsInterventionMachine LearningMental HealthMethodsModelingMonitorNeuronsPerformancePhasePhysiologicalPropertyResponse to stimulus physiologyRodent ModelRouteSchemeStimulusStructureSystemTechniquesTestingTimeTwin Multiple Birthbiophysical modelcognitive functiondesignemotion regulationemotional behaviorexperienceexperimental studygenetic approachimprovedin vivoindividual variationinsightneurophysiologynoveloptogeneticspharmacologicpredictive modelingresponsesignal processingsocialvigilance
项目摘要
Throughout the brain, specialized systems carry out different but complementary functions, sometimes
independently but often in cooperation. However, we do not understand how their activity is dynamically
coordinated, and dysregulation of this is associated with many mental health conditions. Neuronal
oscillations, which are detectable in local field potentials (LFPs) at various frequencies, are a promising
target for this coordination. Gamma oscillations (40-100 Hz) in particular have been singled out since
they enhance stimulus responses, facilitate interactions between brain regions, and are expressed
ubiquitously across cortical and subcortical regions. Indeed, gamma oscillations occur in the basolateral
nucleus of the amygdala (BL), an important regulator of emotional behaviors. BL gamma oscillations are
enhanced during periods of heightened vigilance during a foraging task, following emotionally salient
experiences, and upon presentation of socially-relevant stimuli. The variety of circumstances that engage
it make it a promising target for interventions affecting emotional behaviors in general. However, technical
challenges abound because gamma manifests as brief intermittent oscillatory bursts, layered atop
numerous ongoing activities in other frequency bands. This precludes manipulating gamma exclusively
with traditional pharmacological, optogenetic, or chemogenetic approaches, since these have substantial
effects on ongoing non-gamma activities, and are delivered irrespective of whether gamma bursts are
present or absent. To overcome this, a closed-loop algorithm was developed that monitors the LFP in
real-time for gamma oscillations and delivers precisely timed optogenetic stimulation capable of
enhancing or suppressing gamma strength on a cycle-by-cycle basis. While this improves upon the status
quo,, further refinement is needed. Aim 1 of this proposal seeks to clarify how the gamma modulation
technique operates via biophysically detailed modeling of the local circuits in the BL that generate gamma,
the effects of optogenetic stimulation, and the closed-loop algorithm. Aim 2 designs better signal
processing routines for detecting and parameterizing gamma in real-time. Aim 3 develops an approach to
create customized biophysical models that reproduce the properties of gamma observed in individual
subjects, which when combined with the results of Aims 1 and 2 should allow for optimized control over
gamma oscillations in individual subjects.
RELEVANCE (See instructions):
Gamma oscillations occur in the basolateral amygdala, a brain region implicated in emotional regulation.
By developing improved methods to manipulate these oscillations, we hope to better understand their
function and improve our ability to control emotional states and behaviors.
在整个大脑中,专门的系统执行不同但互补的功能,有时
独立的,但经常合作的。然而,我们不了解它们的活动是如何动态的
这种协调和失调与许多精神健康状况有关。神经元
可以在不同频率的局域场势(LFP)中检测到的振荡是一种很有前途的方法
这一协调的目标。特别是伽马振荡(40-100赫兹)自那以后就被挑出来了
它们增强刺激反应,促进大脑区域之间的相互作用,并表达
普遍存在于皮质和皮质下区域。事实上,伽马振荡发生在基准面
杏仁核(BL),情绪行为的重要调节器。BL伽马振荡是
在觅食任务期间的高度警觉期间得到加强,在情绪上突出
体验,以及在呈现与社会相关的刺激时。参与的各种情况
它使它成为总体上影响情绪行为的干预措施的一个有希望的目标。然而,技术上
挑战比比皆是,因为伽马表现为短暂的间歇性振荡爆发,层叠在
其他频段的许多正在进行的活动。这就排除了专门操纵伽马的可能性
使用传统的药理学、光遗传学或化学遗传学方法,因为这些方法具有实质性的
对正在进行的非伽马活动的影响,并且无论伽马爆发是否
出席或缺席。为了克服这一点,开发了一种闭环算法来监控LFP在
实时伽马振荡并提供精确定时的光遗传刺激,能够
在逐周期的基础上增强或抑制伽马强度。虽然这在状态上有所改善
现状,还需要进一步完善。该提案的目标1试图澄清伽马调制是如何
该技术通过对产生伽马的BL中的局部电路进行生物物理详细建模来操作,
光遗传刺激的效果,以及闭环算法。AIM 2设计更好的信号
用于实时检测和参数化伽马的处理例程。目标3开发了一种方法来
创建定制的生物物理模型,再现个体观察到的伽马属性
受试者,当与目标1和目标2的结果相结合时,应允许对
个体受试者的伽马振荡。
相关性(请参阅说明):
伽马振荡发生在杏仁核的基底外侧,这是一个与情绪调节有关的大脑区域。
通过开发更好的方法来操纵这些振荡,我们希望更好地理解它们
发挥作用,提高我们控制情绪状态和行为的能力。
项目成果
期刊论文数量(12)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Reverse engineering information processing in lateral amygdala during auditory tones.
听觉音调期间外侧杏仁核的逆向工程信息处理。
- DOI:10.1109/ner52421.2023.10123856
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Glickert,Greg;Latimer,Ben;Sah,Pankaj;Nair,SatishS
- 通讯作者:Nair,SatishS
Predicting opioid use disorder before and after the opioid prescribing peak in the United States: A machine learning tool using electronic healthcare records.
在美国的阿片类药物处方峰之前和之后预测阿片类药物使用障碍:使用电子医疗记录的机器学习工具。
- DOI:10.1177/14604582231168826
- 发表时间:2023-04
- 期刊:
- 影响因子:3
- 作者:
- 通讯作者:
Inferring Pyramidal Neuron Morphology using EAP Data.
- DOI:10.1109/ner52421.2023.10123903
- 发表时间:2023-04
- 期刊:
- 影响因子:0
- 作者:Chen, Ziao;Carroll, Matthew;Nair, Satish S.
- 通讯作者:Nair, Satish S.
Classification of Brainwaves Using Convolutional Neural Network.
使用卷积神经网络对脑电波进行分类。
- DOI:10.23919/eusipco.2019.8902952
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Joshi,SwapnilR;Headley,DrewB;Ho,KC;Paré,Denis;Nair,SatishS
- 通讯作者:Nair,SatishS
Domain-Specific Topic Model for Knowledge Discovery in Computational and Data-Intensive Scientific Communities
- DOI:10.1109/tkde.2021.3093350
- 发表时间:2023-02
- 期刊:
- 影响因子:8.9
- 作者:Yuanxun Zhang;P. Calyam;T. Joshi;Satish Nair;Dong Xu
- 通讯作者:Yuanxun Zhang;P. Calyam;T. Joshi;Satish Nair;Dong Xu
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Satish S Nair其他文献
Multiple mechanisms of theta rhythm generation in a model of the hippocampus
- DOI:
10.1186/1471-2202-16-s1-o17 - 发表时间:
2015-12-18 - 期刊:
- 影响因子:2.300
- 作者:
Ali Hummos;Satish S Nair - 通讯作者:
Satish S Nair
Satish S Nair的其他文献
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{{ truncateString('Satish S Nair', 18)}}的其他基金
CRCNS: Optimization of closed-loop control of gamma oscillations
CRCNS:伽马振荡闭环控制的优化
- 批准号:
10002297 - 财政年份:2019
- 资助金额:
$ 28.4万 - 项目类别:
CRCNS: Optimization of closed-loop control of gamma oscillations
CRCNS:伽马振荡闭环控制的优化
- 批准号:
10207403 - 财政年份:2019
- 资助金额:
$ 28.4万 - 项目类别:
CRCNS: Optimization of closed-loop control of gamma oscillations
CRCNS:伽马振荡闭环控制的优化
- 批准号:
10418751 - 财政年份:2019
- 资助金额:
$ 28.4万 - 项目类别:
CRCNS: Optimization of closed-loop control of gamma oscillations
CRCNS:伽马振荡闭环控制的优化
- 批准号:
9914633 - 财政年份:2019
- 资助金额:
$ 28.4万 - 项目类别:
Interdisciplinary Training in Computational Neuroscience for Researchers from Graduate and Medical Students to Junior Faculty
为从研究生、医学生到初级教师的研究人员提供计算神经科学跨学科培训
- 批准号:
9037332 - 财政年份:2015
- 资助金额:
$ 28.4万 - 项目类别:
Interdisciplinary Training in Computational Neuroscience for Researchers from Graduate and Medical Students to Junior Faculty
为从研究生、医学生到初级教师的研究人员提供计算神经科学跨学科培训
- 批准号:
9303447 - 财政年份:2015
- 资助金额:
$ 28.4万 - 项目类别:
CRCNS: Modeling Acquisition and Extinction of Fear Memories in Amygdala Circuits
CRCNS:模拟杏仁核回路中恐惧记忆的获取和消除
- 批准号:
8081062 - 财政年份:2009
- 资助金额:
$ 28.4万 - 项目类别:
CRCNS: Modeling Acquisition and Extinction of Fear Memories in Amygdala Circuits
CRCNS:模拟杏仁核回路中恐惧记忆的获取和消除
- 批准号:
7923205 - 财政年份:2009
- 资助金额:
$ 28.4万 - 项目类别:
CRCNS: Modeling Acquisition and Extinction of Fear Memories in Amygdala Circuits
CRCNS:模拟杏仁核回路中恐惧记忆的获取和消除
- 批准号:
7776621 - 财政年份:2009
- 资助金额:
$ 28.4万 - 项目类别:
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