Developing, Validating, and Implementing an Epidemiological Instrument to Assess the Effect of Resistance Training on Measures of Cardiometabolic Disease

A.项目摘要 骨骼肌是人体内最丰富的胰岛素敏感组织，使其成为重要的器官系统 心脏代谢疾病的预防。阻力训练是一种直接 增加肌肉肥大，从而增加GLUT 4表达。GLUT 4是一种胰岛素调节的 葡萄糖转运蛋白的主要作用是刺激葡萄糖摄取;因此，肥大导致 增加胰岛素敏感性。阻力训练和增强胰岛素敏感性有可能降低胰岛素抵抗。 心血管和代谢疾病的负担。然而，我们所知道的阻力训练的作用， 长期的健康结果受到目前用于测量阻力训练的钝工具的限制， 纵向流行病学研究。体育活动流行病学领域的进展有限， 在人群研究中，阻力训练量的测量精度与有氧运动的测量精度不同 因此，我们不知道运动的最佳平衡，以促进整个生命的健康 当然了本研究的目的是改善目前在抗阻训练量评估中存在的差距， 流行病学水平，并评估阻力训练量如何影响心血管和代谢疾病 单独或与有氧运动联合进行。培训将使科学的目标， 应用程序，这是评估独立和联合协会的阻力训练与估计 胰岛素抵抗和血压。这个奖项将为布克博士提供调查方面的额外培训 发展，2）阻力训练，3）队列发展和4）生物统计学。培训将在 西北大学范伯格医学院，由来自多个导师的强大团队支持 在每个领域都有专门知识的同行机构。在K99阶段，Booker博士将开发和验证一个 流行病学仪器收集阻力训练量（目标1），并确定年龄组， 仪器性能最好。在R 00阶段，Booker博士将使用仪器测定 抗阻训练量与胰岛素抵抗和血压估计值的相关性（目的2）。他将 然后确定用于估计胰岛素抵抗和血压的运动行为的最佳比率， (Aim 3）。拟议的培训和研究将推动布克博士成功地实现他的长期目标。 研究目标是开发量身定制的身体活动训练计划，以促进理想的心血管和 代谢健康阻力训练已经成为全球顶级健身趋势之一， 作为降低心血管和代谢疾病负担的另一种工具。

A. PROJECT SUMMARY Skeletal muscle is the most abundant insulin-sensitive tissue in the body making it an important organ system in the prevention of cardiometabolic disease. Resistance training is the physical activity modality that directly increases muscle hypertrophy and in doing so increases GLUT4 expression. GLUT4 is an insulin-regulated glucose transporter with the primary role of stimulating glucose uptake; therefore, hypertrophy leads to increased insulin sensitivity. Resistance training and enhanced insulin sensitivity have the potential to lower the burden of cardiovascular and metabolic disease. However, what we know about the role of resistance training on long-term health outcomes is limited by the blunt tools currently used to measure resistance training in longitudinal epidemiologic studies. Progress in the physical activity epidemiology field is limited because resistance training volume is not measured in population studies with the same level of precision as aerobic activity and as a result, we do not know the optimal balance of movements to promote health across the life course. The objective of the proposed research is to ameliorate the gap in assessing resistance training volume at an epidemiological level and assess how resistance training volume affects cardiovascular and metabolic disease independently and jointly with aerobic activity. The training will enable the scientific objectives of this application, which are to evaluate the independent and joint associations of resistance training with estimates of insulin resistance and blood pressure. This award will provide Dr. Booker with added training in 1) survey development, 2) resistance training, 3) cohort development, and 4) biostatistics. Training will take place at Northwestern University Feinberg School of Medicine, supported by a strong team of mentors from multiple peer institutions with expertise in each of these areas. In the K99 phase, Dr. Booker will develop and validate an epidemiological instrument to collect resistance training volume (Aim 1) and identify the age group where the instrument performs the best. During the R00 phase, Dr. Booker will use the instrument to determine the association of resistance training volume with estimates of insulin resistance and blood pressure (Aim 2). He will then determine the optimal ratio of movement behaviors for estimates of insulin resistance and blood pressure (Aim 3). The proposed training and research will propel Dr. Booker towards successfully achieving his long-term research goal of developing tailored physical activity training programs to promote ideal cardiovascular and metabolic health. Resistance training has emerged among the top fitness trends worldwide and has the potential to serve as another tool to lower the burden of cardiovascular and metabolic diseases.