Developing, Validating, and Implementing an Epidemiological Instrument to Assess the Effect of Resistance Training on Measures of Cardiometabolic Disease

A.项目总结 骨骼肌是体内最丰富的胰岛素敏感组织，使其成为重要的器官系统 在预防心脏代谢性疾病方面。抵抗力训练是一种直接 增加肌肉肥大，从而增加GLUT4的表达。GLUT4是一种受胰岛素调节的 葡萄糖转运蛋白具有刺激葡萄糖摄取的主要作用；因此，肥大导致 胰岛素敏感度增加。阻力训练和增强的胰岛素敏感性有可能降低 心血管和代谢性疾病的负担。然而，我们所知道的关于阻力训练在 长期健康结果受到目前用于测量阻力训练的钝化工具的限制 纵向流行病学研究。体力活动流行病学领域的进展有限，因为 在人群研究中，阻力训练量的测量不像有氧运动那样精确 因此，我们不知道在生活中促进健康的运动的最佳平衡 当然了。拟议研究的目的是改善在评估阻力训练量方面的差距 流行病学水平并评估阻力训练量如何影响心血管和代谢性疾病 独立和联合进行有氧运动。培训将使这一科学目标成为可能 应用程序，用于评估抵抗力训练的独立和联合联系 胰岛素抵抗和血压。该奖项将为布克博士在调查方面提供额外的培训 发展，2)抗力训练，3)队列发展，4)生物统计学。培训将在以下时间进行 西北大学范伯格医学院，由来自多个国家的强大导师团队提供支持 在这些领域都有专业知识的同行机构。在K99阶段，Booker博士将开发和验证 用于收集抗药性训练量的流行病学工具(目标1)，并确定 乐器的表现最好。在R00阶段，Booker博士将使用该仪器确定 抵抗训练量与胰岛素抵抗和血压估计的关系(目标2)。他会的 然后确定用于估计胰岛素抵抗和血压的运动行为的最佳比率 (目标3)。拟议的培训和研究将推动布克博士成功地实现他的长期 制定量身定制的体力活动训练计划以促进理想的心血管和 新陈代谢健康。阻力训练已跻身全球健身潮流之列，并具有潜力 作为减轻心血管和代谢性疾病负担的另一种工具。

A. PROJECT SUMMARY Skeletal muscle is the most abundant insulin-sensitive tissue in the body making it an important organ system in the prevention of cardiometabolic disease. Resistance training is the physical activity modality that directly increases muscle hypertrophy and in doing so increases GLUT4 expression. GLUT4 is an insulin-regulated glucose transporter with the primary role of stimulating glucose uptake; therefore, hypertrophy leads to increased insulin sensitivity. Resistance training and enhanced insulin sensitivity have the potential to lower the burden of cardiovascular and metabolic disease. However, what we know about the role of resistance training on long-term health outcomes is limited by the blunt tools currently used to measure resistance training in longitudinal epidemiologic studies. Progress in the physical activity epidemiology field is limited because resistance training volume is not measured in population studies with the same level of precision as aerobic activity and as a result, we do not know the optimal balance of movements to promote health across the life course. The objective of the proposed research is to ameliorate the gap in assessing resistance training volume at an epidemiological level and assess how resistance training volume affects cardiovascular and metabolic disease independently and jointly with aerobic activity. The training will enable the scientific objectives of this application, which are to evaluate the independent and joint associations of resistance training with estimates of insulin resistance and blood pressure. This award will provide Dr. Booker with added training in 1) survey development, 2) resistance training, 3) cohort development, and 4) biostatistics. Training will take place at Northwestern University Feinberg School of Medicine, supported by a strong team of mentors from multiple peer institutions with expertise in each of these areas. In the K99 phase, Dr. Booker will develop and validate an epidemiological instrument to collect resistance training volume (Aim 1) and identify the age group where the instrument performs the best. During the R00 phase, Dr. Booker will use the instrument to determine the association of resistance training volume with estimates of insulin resistance and blood pressure (Aim 2). He will then determine the optimal ratio of movement behaviors for estimates of insulin resistance and blood pressure (Aim 3). The proposed training and research will propel Dr. Booker towards successfully achieving his long-term research goal of developing tailored physical activity training programs to promote ideal cardiovascular and metabolic health. Resistance training has emerged among the top fitness trends worldwide and has the potential to serve as another tool to lower the burden of cardiovascular and metabolic diseases.