Preserving Cognitive Resilience: A Biracial Parent-Offspring Study

在老年时保持认知弹性可以防止老年认知能力的丧失。考虑到漫长的前驱期 认知丧失阶段，确定晚年认知弹性的中年危险因素的意义可能 从而在一般人群中制定更好的预防战略。较高的患病率和发病率 阿尔茨海默病（AD）在少数民族人群中，特别是非洲裔美国人， 在这一具有高度公共卫生意义的人群中。三个重点领域-神经影像学生物标志物，认知 测试和中年CVD危险因素将提供更好的了解中年因素，可能与 晚年认知恢复力我们的目标是招募750名其父母参加了这项研究的后代。 一项双胞胎人口研究，主要目的是测试父母的认知弹性是否更高， 与脑梗死患者的白色物质、海马和皮质灰质损伤的MRI证据较少相关。 后代，并测试这些关联是否因种族/民族和性别群体而不同。的目标之一 本研究的目的是确定推定的危险因素和保护因素对认知功能的影响。 10，342名参与者在父母研究中的恢复力。父级中不会收集新数据 队列。第二和第三个目的是检查MRI神经影像学生物标志物与认知功能障碍的关系。 测试和颈动脉股动脉脉搏波速度和收缩压在后代队列，并检查这些 父母具有更高认知弹性的后代之间的关系更强，按种族/民族划分， 性别和APOE E4等位基因。这样一种跨代的方法，在一个双胞胎的认知弹性， 人口样本研究认知弹性是新颖的，并提供了一个独特的机会，以提高我们的 对几代美国人认知恢复力的理解。这项研究也有可能 在潜在地识别认知弹性的早期、中期和晚期因素方面产生巨大的公共卫生影响 从而在中年时期采取更好的预防策略。

Preserving cognitive resilience in old age can prevent loss of cognition in old age. Given the long prodromal phase of cognitive loss, the significance of identifying midlife risk factors of late-life cognitive resilience may lead to better preventive strategies in the general population. The higher prevalence and incidence of Alzheimer's disease (AD) in the minority populations, especially African Americans, makes studying resilience in this population of high public health significance. Three areas of focus – neuroimaging biomarkers, cognitive tests, and CVD risk factors in midlife will provide a better understanding of midlife factors that may be related to late-life cognitive resilience. We aim to enroll 750 offspring whose parents were participants in the CHAP biracial population study with the following primary objective – to test if higher parental cognitive resilience is associated with less MRI evidence of white matter, hippocampal, and cortical gray matter injury in the offspring, and to test if these associations are different by race/ethnicity and gender groups. One of the aims of the study is to identify the contributions of putative risk and protective factors over life span on cognitive resilience in the 10,342 participants in the parent CHAP study. No new data will be collected in the Parent Cohort. The second and third aims are to examine the relation of MRI neuroimaging biomarkers with cognitive tests and carotid femoral pulse wave velocity and systolic BP in the offspring cohort, and examine if these relationships are stronger among offspring whose parents have higher cognitive resilience, by race/ethnicity, gender, and by the APOE E4 allele. Such an intergenerational approach to cognitive resilience in a biracial population sample to study cognitive resilience is novel and provides a unique opportunity to improve our understanding of cognitive resilience across generations of Americans. This study also has the potential to make a large public health impact in potentially identifying early, mid, and late life factors of cognitive resilience leading to better preventive strategies in midlife.