Preserving Cognitive Resilience: A Biracial Parent-Offspring Study

保持认知弹性：一项混血亲子研究

• 批准号: 10646135
• 负责人: DENIS A EVANS
• 金额: $ 280.9万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646135
• 关键词: Affect; African American population; Age; Aging; Alleles; Alzheimer' s Disease; American; Area; Autopsy; Biological Markers; Body mass index; Brain; Cardiovascular Diseases; Chicago; Clinical; Cognition; Cognitive; Data; Data Analyses; Early identification; Economics; Elderly; Enrollment; Epidemiology; Ethnic Origin; Female; Femur; Gender; General Population; Generations; Health; High Prevalence; Hippocampus; Impaired cognition; Incidence; Individual; Injury; Intergenerational Relations; Life Cycle Stages; Longevity; Magnetic Resonance Imaging; Measures; Minority Groups; Modeling; Neurotic Disorders; Occupations; Parents; Participant; Personality Traits; Persons; Pharmaceutical Preparations; Phase; Physical Function; Physiologic pulse; Population; Population Study; Prevention strategy; Process; Public Health; Race; Research; Residual state; Risk Factors; Risk Reduction; Sampling; Schools; Social Network; Testing; Work; aged; aging population; apolipoprotein E-4; biracial; brain health; cardiovascular disorder risk; cardiovascular health; cognitive ability; cognitive change; cognitive function; cognitive performance; cognitive testing; cohort; dementia risk; depressive symptoms; design; early life adversity; epidemiologic data; follow-up; gray matter; human old age (65+); improved; indexing; intergenerational; middle age; modifiable risk; neuroimaging; neuroimaging marker; neuropathology; novel; offspring; performance tests; preservation; prevent; protective factors; psychologic; racial population; recruit; research study; resilience; resilience research; response; sex; slow potential; social; social factors; white matter

Preserving cognitive resilience in old age can prevent loss of cognition in old age. Given the long prodromal phase of cognitive loss, the significance of identifying midlife risk factors of late-life cognitive resilience may lead to better preventive strategies in the general population. The higher prevalence and incidence of Alzheimer's disease (AD) in the minority populations, especially African Americans, makes studying resilience in this population of high public health significance. Three areas of focus – neuroimaging biomarkers, cognitive tests, and CVD risk factors in midlife will provide a better understanding of midlife factors that may be related to late-life cognitive resilience. We aim to enroll 750 offspring whose parents were participants in the CHAP biracial population study with the following primary objective – to test if higher parental cognitive resilience is associated with less MRI evidence of white matter, hippocampal, and cortical gray matter injury in the offspring, and to test if these associations are different by race/ethnicity and gender groups. One of the aims of the study is to identify the contributions of putative risk and protective factors over life span on cognitive resilience in the 10,342 participants in the parent CHAP study. No new data will be collected in the Parent Cohort. The second and third aims are to examine the relation of MRI neuroimaging biomarkers with cognitive tests and carotid femoral pulse wave velocity and systolic BP in the offspring cohort, and examine if these relationships are stronger among offspring whose parents have higher cognitive resilience, by race/ethnicity, gender, and by the APOE E4 allele. Such an intergenerational approach to cognitive resilience in a biracial population sample to study cognitive resilience is novel and provides a unique opportunity to improve our understanding of cognitive resilience across generations of Americans. This study also has the potential to make a large public health impact in potentially identifying early, mid, and late life factors of cognitive resilience leading to better preventive strategies in midlife.

在老年时保持认知韧性可以防止老年时认知能力的丧失。考虑到长长的前奏 认知丧失阶段，识别晚年认知韧性的中年风险因素的意义可能 在普通人群中促成更好的预防策略。较高的患病率和发病率 阿尔茨海默病(AD)在少数族裔人群，特别是非裔美国人中的存在，使得研究弹性 在这一人群中具有很高的公共卫生意义。三个重点领域-神经成像生物标记物，认知 测试和中年心血管疾病风险因素将提供对中年因素的更好理解，这些因素可能与 晚年认知韧性。我们的目标是招募750名父母参与该项目的后代 具有以下主要目标的混血人群研究--测试父母较高的认知韧性是否 与白质、海马区和皮质灰质损伤的MRI证据较少相关 并测试这些关联是否因种族/族裔和性别群体而有所不同。的目标之一 这项研究是为了确定假定的风险和保护因素对认知能力的影响。 家长CHAP研究中10,342名参与者的复原力。不会在父级中收集任何新数据 一群人。第二和第三个目标是检查核磁共振神经成像生物标志物与认知的关系。 在后代队列中进行颈动脉脉搏波速度和收缩压的测试，并检查这些指标 根据种族/民族，父母认知韧性较高的子女之间的关系更牢固， 性别和载脂蛋白E4等位基因。这种代际方法在两族人中的认知复原力 人口样本研究认知韧性是新颖的，并提供了一个独特的机会，以改善我们的 几代美国人对认知韧性的理解。这项研究也有可能 潜在地确定认知复原力的早期、中期和晚期因素，从而对公共健康产生重大影响 从而在中年制定更好的预防策略。

项目成果

Association of Vitamin E and Cognitive Decline in Older Adults with and without the APOEɛ4 Allele: A Biracial Population-Based Community Study.

有或没有 APOEÉ4 等位基因的老年人维生素 E 与认​​知能力下降的关联：一项基于混血儿群体的社区研究。

• DOI: 10.3233/jad-230797
• 发表时间: 2023
• 期刊: Journal of Alzheimer's disease : JAD
• 作者: Liu,Xiaoran;Finno,CarrieJ;Beck,Todd;Dhana,Klodian;Tangney,Christy;Desai,Pankaja;Krueger,Kristin;Evans,DenisA;Rajan,KumarB
• 通讯作者: Rajan,KumarB