Preserving Cognitive Resilience: A Biracial Parent-Offspring Study (18-4674) - Feasibility Study

母公司NIA赠款(R01AG058679，MPIS：Rajan&Evans，2019-2024)的具体目标有三个 构成部分：(1)调查与流行病学有关的因素，包括行为和社会因素- 在芝加哥健康和老龄化项目的双族人群研究中得出的认知弹性(CHAP：AGE 65岁以上，60%非裔美国人[AAS])；(2)招募混血后代队列，父母后代韧性 和认知健康(Porch：年龄：40-，50%AAS)研究；(3)考察认知弹性在 父母与子女的全球认知和MCI和痴呆症的风险有关。冠状病毒病 2019年(新冠肺炎)摧毁了全球人口，并在美国产生了很大影响。这个 新冠肺炎的传播受到人口统计、行为和社会的强烈影响 特征，也可能通过增加风险而对认知功能产生实质性影响的因素 老年父母和中年子女的MCI和痴呆症的风险，以及老年人认知弹性的降低 父母，父母赠款的主要结果。 为期一年的行政副刊将检验社区层面测试新冠肺炎的可行性 通过自服SARS-CoV-2RNA鼻拭子和指棒抗体检测。最重要的是，它可以 提供有关新冠肺炎感染影响的初步数据，以及行为和社会因素，如 家庭环境、流行病压力和社会距离对100名老年男性父母认知健康的影响 100名中年门廊后代的AA值为50%。本行政副刊将进行可行性研究 在一个具有良好特征、种族多元化、以社区为基础的地区检测SARS-CoV-2抗原和抗体 与大量AA的亲子研究。此外，为加强研究提供了可行性 通过增加新冠肺炎来扩大家长资助目标1和3的家长门廊研究的价值 暴露导致父母认知韧性降低，并通过增加 新冠肺炎暴露导致子代核磁共振损伤的行为和社会特征 指数、认知表现和BP，以及检查这些指标中可能存在的种族/民族差异的可行性 效果。

The specific aims of the parent NIA grant (R01AG058679, MPIs: Rajan & Evans, 2019-2024) has three components: (1) Investigate factors, including behavioral and social factors, associated with epidemiologically- derived cognitive resilience in a biracial population study, the Chicago Health and Aging Project (CHAP: Age 65+ years, 60% African Americans [AAs]); (2) Recruit a biracial offspring cohort, Parent Offspring Resilience and Cognitive Health (PORCH: Age: 40-64, 50% AAs) study; (3) Examine whether cognitive resilience in parents are associated with global cognition and risk of MCI and dementia in offspring. Coronavirus disease 2019 (COVID-19) has devastated global populations and has had a large impact in the United States. The transmission of COVID-19 is strongly influenced by population demographics, behavioral, and social characteristics, factors which might also have a substantial impact on cognitive function by increasing the risk of MCI and dementia in older parents and midlife offspring, and by reducing cognitive resilience in older parents, the primary outcomes of the parent grant. The one-year Administrative Supplement will test the feasibility of community-level COVID-19 testing through self-administered SARS-CoV-2 RNA nasal swab and fingerstick antibodies testing. Crucially, it can provide preliminary data on the impact of COVID-19 infections, and behavioral and social factors, such as, household environment, pandemic stress, and social distancing on cognitive health in 100 older CHAP parents and 100 midlife PORCH offspring with 50% AAs. This administrative supplement will conduct a feasibility study to test SARS-CoV-2 antigens and antibodies in a well characterized, ethnically diverse, community-based parent-offspring study with a large number of AAs. Additionally, provide feasibility to enhance the research value of the parent PORCH study by expanding parent grant Aims 1 and 3 through adding COVID-19 to the exposures leading to decreased parental cognitive resilience and expanding parent grant Aim 3 by adding behavioral and social characteristics and COVID-19 to the exposures leading to impaired offspring MRI Indices, cognitive performance and BP, and feasibility to examine possible racial/ethnic differences in these effects.