CORE--DATA MANAGEMENT AND BIOSTATISTICS

描述(由申请人提供)： 数据管理和生物统计核心为Rush ADCC和每个 它的组件核心能够有效地处理大量 他们收集的数据，将这些数据保存在高效的数据集中 适当保护机密性，并提供所需的技能 对这些数据进行精心挑选的统计分析。核心支撑 用于所有数据的计算机辅助数据采集系统 ADCC内的集合，但小型数据集除外。这是计算机辅助的 该方法提供了更高的数据质量，减少了丢失数据和超出范围 值，有机会检测和纠正错误的减少数量 及时发生，更快地获得高质量的数据 分析和消除复式数据键控服务的成本。在……里面 在ADCC中，计算机辅助方法的这些优势有很大的 超过了最初较高的方案编制和培训费用。之后 集合时，所有ADCC核心中的数据都在 关系数据库管理系统。从此系统生成的报告 监控从数据收集人员到数据中心的数据传输过程 数据库，跟踪数据收集进度，评估数据质量，以及 监控纠正任何错误的过程。多级别安全 程序用于确保数据的机密性和完整性。 数据管理和生物统计核心为其他领域的研究人员提供 核心人员可获得关于统计问题的专家意见和适当的 分析技术。因为强烈强调收集 在ADCC堆芯纵向数据方面，也有相应的设计重点 并进行纵向统计分析。使用专家统计方法 不仅强调了数据管理和生物统计核心的观点 在进行分析时，但在研究设计中也是如此。核心不是 直接对独立资助的研究进行数据分析， 利用ADCC数据，但提供有关 数据和适当分析技术的选择。核心还提供 支持和积极参与数据共享的机制 以及NIA资助的所有阿尔茨海默病患者之间的联合数据管理活动 中锋。

DESCRIPTION (provided by applicant): The Data Management and Biostatistics Core provides the Rush ADCC and each of its component cores with the ability to efficiently handle the large amounts of data they collect, maintains these data in efficient data sets with appropriate protection of confidentiality, and offers the skills needed to conduct well chosen statistical analyses of these data. The Core supports computer assisted data acquisition systems that are used for all data collection within the ADCC, except for small data sets. This computer-assisted approach offers improved data quality with fewer missing data and out-of-range values, opportunity to detect and correct the reduced number of errors that do occur in a timely fashion, more rapid availability of high quality data for analysis and elimination of the cost of double-entry data keying services. In the ADCC, these advantages of a computer-assisted approach have greatly outweighed its initially higher costs for programming and training. After collection, data from all ADCC cores are maintained in tables within a relational database management system. Reports generated from this system monitor the process of data transfer from the data collection staff to the database, track the progress of data collection, assess data quality, and monitor the process of correcting any errors. Multiple-level security procedures are used to assure the confidentiality and integrity of the data. The Data Management and Biostatistics Core provides investigators in other cores access to expert opinion on statistical issues and to appropriate analytic techniques. Because of the strong emphasis on collection of longitudinal data in the ADCC cores, there is corresponding emphasis on design and conduct of longitudinal statistical analyses. Use of expert statistical opinion from the Data Management and Biostatistics Core is emphasized not only in the conduct of analyses, but in study design as well. The Core does not directly conduct data analyses for the independently funded studies that utilize ADCC data, but provides guidance regarding the characteristics of the data and selection of appropriate analytic techniques. The Core also provides a mechanism for the ADCC to support and participate actively in data sharing and joint data management activities among all NIA-funded Alzheimer's Disease Centers.