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Aging Animal Models and Longevity Assessment Core

衰老动物模型和长寿评估核心

基本信息

批准号：
10652360
负责人：
JAMES FLOYD NELSON
金额：
$ 17.34万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-07-15 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10652360
关键词：
Address Adrenal Gland Hyperfunction Age Aging Animal Experimentation Animal Model Animals Applications Grants Autophagocytosis Biological Biology Biology of Aging Breeding Callithrix Callithrix jacchus jacchus Caloric Restriction Cells Consultations Continuity of Patient Care Data Data Analyses Data Collection Development Disease Dissection Documentation Education Four Core Genotypes Funding Gender Generations Gerontology Goals Health Inflammation Institution Intervention Intervention Studies Kidney Knowledge Leadership Longevity Maintenance Mammals Manuscripts Measurable Measures Mission Modeling Mole Rats Molecular Monitor Mus Nutritional Pathologic Pharmaceutical Preparations Phase Phenotype Physiological Play Preparation Process Publications Rattus Recording of previous events Reproducibility Research Research Personnel Resources Rodent Rodent Model Role Sampling Services Sex Differences Shock Skeletal Muscle Study models Tissues Training United States National Institutes of Health Work age effect age related base cost effective design dietary genotypic sex healthspan healthy aging human female in vivo innovation interest life history mouse model nerve stem cell nonhuman primate novel pharmacologic programs protective effect sex sexual dimorphism sound tool

项目摘要

The Aging Animal Models and Longevity Assessment Core (Animal Core) will continue a nearly 25 year history of leadership, service, training and innovation in 1) providing new and established aging animal models, 2) administering nutritional and pharmacologic interventions, and 3) collecting lifespan and life-history data for investigators in San Antonio and across the nation. The Animal Core is an essentail pillar of the San Antonio (SA) Shock Center's overarching mission - to provide investigators with the resources required to integrate lifespan and pathologic data with physiologic (healthspan) and molecular aging phenotypes for the expansion of knowledge on the biology of aging and the identification of pharmacological and nutritional targets to promote heathy aging. The Core achieves its goals through the following Specific Aims: 1) To breed and age new and established investigator-driven rodent models to elucidate mechanisms of aging. 2) To conduct lifespan studies of genetically, nutritionally, and pharmacologically manipulated mice and rats. 3) To provide aging marmosets to facilitate research on mechanisms of aging in non-human primates. 4) To educate and advise investigators on the requirements for rigor and reproducibility in aging animal research. The Core is housed in facilities specifically designed for the exclusive husbandry of aging animals. It provides exceptional continuity of care and data collection by highly trained staff. It is the only Core providing access to aging mice, rats, naked-mole rats and a non-human primate model, the common marmoset. Over the past 5 years, the Animal Core has continued its history of providing services to many investigators across the nation, supporting multiple grant applications and publications, and contributing to impactful advances in the biology of aging including: a) identification of the first murine model of the human female survival advantage; b) discovery of the protective effect of calorie restriction on aging neural stem cells; c) demonstration of a central role for hyperadrenocorticism in the suppression of inflammation by calorie restriction; d) discovery of a causal role of H2S generation on kidney aging in mice; and e) establishing the first interventional lifespan extension study with a pharmacologic agent in marmosets. These and other advances enabled by the Animal Core underscore its importance as a generator of biogerontologic discovery.

衰老动物模型和寿命评估核心（Animal Core）将持续近25年领导，服务，培训和创新的历史1）提供新的和建立的衰老动物模型， 2)管理营养和药物干预，以及3）收集寿命和生活史数据，圣安东尼奥和全国各地的调查人员。动物中心是圣安东尼奥的重要支柱 (SA)休克中心的首要使命-提供调查所需的资源，寿命和病理数据与生理（healthspan）和分子老化表型的扩展知识的生物学老化和药理学和营养目标的识别，以促进健康衰老核心通过以下具体目标实现其目标： 1)繁殖和老化新的和已建立的致衰老驱动啮齿动物模型，以阐明衰老机制。 2)对遗传、营养和免疫操作的小鼠和大鼠进行寿命研究。 3)为非人灵长类动物衰老机制的研究提供衰老绒猴。 4)教育和建议研究人员在老化动物研究中的严格性和再现性要求。核心饲养在专门为老龄动物专门饲养设计的设施中。它提供由训练有素的工作人员进行持续的护理和数据收集。它是唯一提供访问权限的核心衰老小鼠、大鼠、裸鼹鼠和非人灵长类动物模型普通绒猴。过去5 多年来，动物核心继续其为全国各地的许多调查人员提供服务的历史，支持多项资助申请和出版物，并为生物学领域的有影响力的进步做出贡献。衰老包括：a）鉴定人类女性生存优势的第一个鼠模型; B）发现热量限制对衰老神经干细胞的保护作用; c）证明了通过热量限制抑制炎症中的肾上腺皮质功能亢进; d）发现H2S的因果作用 e）建立第一个干预性寿命延长研究，在绒猴中的药理作用。动物核心所实现的这些和其他进步强调了其重要性作为一个发电机的考古发现。