Aging Animal Models and Longevity Assessment Core

老龄动物模型和长寿评估核心(Animal Core)将持续近25年 1)提供新的和已建立的衰老动物模型方面的领导、服务、培训和创新的历史， 2)实施营养和药物干预，以及3)收集寿命和生活史数据 圣安东尼奥和全国各地的调查人员。动物核心是圣安东尼奥不可缺少的支柱 (SA)休克中心的首要任务--向调查人员提供整合 寿命和病理数据与生理(健康寿命)和分子衰老表型的扩展 关于衰老生物学的知识以及确定药理和营养目标以促进 健康的衰老。核心通过以下具体目标实现其目标： 1)培育和老化新的和已建立的研究者驱动的啮齿动物模型，以阐明衰老的机制。 2)对基因、营养和药物操作的小鼠和大鼠进行寿命研究。 3)提供老化的绒猴，以便于研究非人类灵长类动物的衰老机制。 4)就老龄动物研究的严密性和重复性的要求对研究人员进行教育和建议。 核心被安置在专门为老年动物饲养而设计的设施中。它提供了 由训练有素的工作人员提供卓越的连续性护理和数据收集。它是唯一提供访问 衰老的小鼠、大鼠、裸鼠和一种非人类灵长类动物模型--常见的绒猴。在过去5年中 多年来，动物核心中心继续为全国各地的许多调查人员提供服务， 支持多项赠款申请和出版物，并促进在生物科学领域取得有影响力的进展 老龄化包括：a)确定人类女性生存优势的第一个小鼠模型；b)发现 卡路里限制对老化的神经干细胞的保护作用；c)证明 肾上腺皮质功能亢进在卡路里限制抑制炎症中的作用；d)发现硫化氢的因果作用 关于小鼠肾脏老化的世代研究；以及e)建立第一个介入性延长寿命研究 绒猴体内的药理药剂。这些和其他由动物核心实现的进步强调了它的 作为生物老年学发现的推动者的重要性。

The Aging Animal Models and Longevity Assessment Core (Animal Core) will continue a nearly 25 year history of leadership, service, training and innovation in 1) providing new and established aging animal models, 2) administering nutritional and pharmacologic interventions, and 3) collecting lifespan and life-history data for investigators in San Antonio and across the nation. The Animal Core is an essentail pillar of the San Antonio (SA) Shock Center's overarching mission - to provide investigators with the resources required to integrate lifespan and pathologic data with physiologic (healthspan) and molecular aging phenotypes for the expansion of knowledge on the biology of aging and the identification of pharmacological and nutritional targets to promote heathy aging. The Core achieves its goals through the following Specific Aims: 1) To breed and age new and established investigator-driven rodent models to elucidate mechanisms of aging. 2) To conduct lifespan studies of genetically, nutritionally, and pharmacologically manipulated mice and rats. 3) To provide aging marmosets to facilitate research on mechanisms of aging in non-human primates. 4) To educate and advise investigators on the requirements for rigor and reproducibility in aging animal research. The Core is housed in facilities specifically designed for the exclusive husbandry of aging animals. It provides exceptional continuity of care and data collection by highly trained staff. It is the only Core providing access to aging mice, rats, naked-mole rats and a non-human primate model, the common marmoset. Over the past 5 years, the Animal Core has continued its history of providing services to many investigators across the nation, supporting multiple grant applications and publications, and contributing to impactful advances in the biology of aging including: a) identification of the first murine model of the human female survival advantage; b) discovery of the protective effect of calorie restriction on aging neural stem cells; c) demonstration of a central role for hyperadrenocorticism in the suppression of inflammation by calorie restriction; d) discovery of a causal role of H2S generation on kidney aging in mice; and e) establishing the first interventional lifespan extension study with a pharmacologic agent in marmosets. These and other advances enabled by the Animal Core underscore its importance as a generator of biogerontologic discovery.