ANIMAL CORE

动物核心

• 批准号: 6946251
• 负责人: JAMES FLOYD NELSON
• 金额: $ 15.67万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6946251
• 关键词: aging; animal breeding; animal colony; animal morbidity; biological models; biomedical facility; body composition; body weight; fibroblasts; health care personnel education; laboratory mouse; laboratory rat; life cycle; longevity; model design /development; nutrient intake activity; tissue /cell culture

The Animal Core will continue to play a central role in the Nathan Shock Aging Center at the UTHSCSA. Its principal aim is to provide Center Investigators with a spectrum of uniformly maintained, specific-pathogen-free mouse models for the study of aging. It will breed, maintain, and monitor aging colonies of new as well as established rodent models. The Core will determine the longevity of these models, measure life-history and age-sensitive traits, including body weight, body composition, food intake, and morbidity. The Core will distribute animals to Center members for basic research on aging. The Core will continue to be investigator-driven: namely, all models will either 1) be supported by grants or 2) will be selected from those proposed by Center investigators to be the most likely to give insight into fundamental mechanisms of aging and most promising for independent funding.

动物核心将继续在UTHSCSA的内森休克衰老中心发挥核心作用。其主要目的是为中心研究人员提供一系列统一维护的、无特定病原体的小鼠模型，用于衰老研究。它将繁殖、维护和监测新的和已建立的啮齿动物模型的老化菌落。核心将确定这些模型的寿命，测量生活史和年龄敏感特征，包括体重，身体成分，食物摄入量和发病率。核心将分发动物给中心成员进行衰老的基础研究。核心项目将继续由赞助商驱动：即所有模式要么1）由赠款支持，要么2）从 该中心的研究人员提出，最有可能深入了解衰老的基本机制，最有希望获得独立的资金。