ANIMAL CORE

动物核心将继续在UTHSCSA的内森冲击老化中心发挥核心作用。其主要目的是为中心研究人员提供一个统一维护的，无特定病原体的小鼠模型的光谱，用于研究衰老。它将培育、维持和监测新的和已建立的啮齿动物模型的老化菌落。Core将确定这些模型的寿命，测量生活史和年龄敏感特征，包括体重、身体成分、食物摄入量和发病率。该中心将把动物分发给中心成员，用于衰老基础研究。核心将继续由研究者驱动：也就是说，所有模型将要么1)由拨款支持，要么2)从中选择

The Animal Core will continue to play a central role in the Nathan Shock Aging Center at the UTHSCSA. Its principal aim is to provide Center Investigators with a spectrum of uniformly maintained, specific-pathogen-free mouse models for the study of aging. It will breed, maintain, and monitor aging colonies of new as well as established rodent models. The Core will determine the longevity of these models, measure life-history and age-sensitive traits, including body weight, body composition, food intake, and morbidity. The Core will distribute animals to Center members for basic research on aging. The Core will continue to be investigator-driven: namely, all models will either 1) be supported by grants or 2) will be selected from those proposed by Center investigators to be the most likely to give insight into fundamental mechanisms of aging and most promising for independent funding.