CORE--ANIMAL

核心--动物

• 批准号: 6201045
• 负责人: JAMES FLOYD NELSON
• 金额: $ 13.26万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6201045
• 关键词: aging; biological models; biomedical facility; laboratory mouse; laboratory rat

Central to this proposal for a Nathan Shock Aging Center is a program to develop, maintain, and distribute nutritionally-controlled and pathologically-defined rodent models that are genetically, nutritionally or pharmacologically modified in ways that will allow investigators to test hypotheses concerning aging or age-related diseases. These models will then be examined by Center investigators at the molecular, cellular, and organismic levels to determine whether and how aging is altered. The Animal Core is an integral part of this effort and its overall goal is to maintain, monitor, and distribute new and established animal models for the purpose of testing hypotheses concerning the mechanism(s) underlying aging. The specific aims of the Animal Core are as follows: 1. To establish, maintain, and characterize several new rodent models that can be used to study the mechanisms of aging and/or age-related disease process. Colonies of animals that have been genetically modified or treated with a nutritional and/or pharmacological intervention will be maintained under barrier conditions, and the survival of these colonies will be determined. Animals from these colonies will be made available to Center investigators. 2. To maintain colonies of C57B1/6 mice and Fischer 344 rats under well- defined, barrier conditions and to determine the survival of these colonies. Animals from these colonies will be made available to Center investigator. 3. To coordinate and optimize the distribution of tissues from animals in the Animal Core to faculty at UTHSC-SA and ALMMVH. 4. To assist faculty in maintaining aging colonies of rodents that are supported with funds from independent grants. 5. To advise faculty and students interested in aging on the special requirements of animal husbandry in aging research.

Nathan冲击衰老中心的这一建议的核心是一项计划 开发，维护和分发营养控制的，并且 病理定义的啮齿动物模型，在遗传，营养或 在药理学上修改的方式将允许研究人员测试 关于衰老或与年龄有关的疾病的假设。 这些模型将 然后由中心研究人员在分子，细胞和 有机水平确定衰老是否发生变化。 这 动物核心是这项工作不可或缺的一部分，其总体目标是 维护，监视和分发新的和已建立的动物模型 测试有关基本机制的假设的目的 老化。 动物核心的具体目的如下： 1。建立，维护和表征几种新的啮齿动物模型 可用于研究衰老和/或与年龄有关的机制 疾病过程。 已经被基因修饰的动物的菌落 或接受营养和/或药理干预治疗 保持在障碍条件下以及这些菌落的生存 将确定。 这些殖民地的动物将被提供 中心调查人员。 2。维持C57B1/6小鼠的菌落和Fischer 344大鼠。 定义，屏障条件并确定这些生存 殖民地。 这些殖民地的动物将被提供到中心 研究者。 3。协调和优化动物中组织的分布 UTHSC-SA和ALMMVH的教师的动物核心。 4。协助教师维持啮齿动物的衰老菌落 由独立赠款的资金支持。 5。建议教师和有兴趣衰老的学生 畜牧业在衰老研究中的要求。