Prenatal cannabis: A fetal neuroimaging study of neurodevelopment

产前大麻：神经发育的胎儿神经影像学研究

基本信息

批准号：
10653949
负责人：
Claudia I Lugo-Candelas
金额：
$ 57.14万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10653949
关键词：
Address Adolescent Adult Affect Alcohols Anxiety Attention deficit hyperactivity disorder Autopsy Behavior assessment Behavioral Benign Binding Blood - brain barrier anatomy Brain CNR1 gene Canada Cannabis Child Cigarette Cocaine Cognitive Collaborations Corpus striatum structure Data Development Dopamine Drug usage Early identification Enrollment Environment Environmental Risk Factor Executive Dysfunction Exposure to Family Female First Pregnancy Trimester Functional Magnetic Resonance Imaging Future Genetic Health Policy Healthcare Systems High Prevalence Home environment Human Infant Infant Behavior Intervention Laboratories Legal Life Link MRI Scans Magnetic Resonance Imaging Measures Mediating Medical center Minnesota Moods Mothers Nausea Neurons North America Opioid Outcome Parents Patient Self-Report Perinatal Pharmaceutical Preparations Phenotype Placenta Postpartum Period Predisposition Prefrontal Cortex Pregnancy Pregnant Women Prenatal care Prevention Prevention strategy Psychoses Public Health Quebec Recording of previous events Recreation Reporting Research Risk Rodent Safety Specificity Stress Structure Substance of Abuse Teenagers Tetrahydrocannabinol Third Pregnancy Trimester Toxicology Universities Withdrawal Symptom Woman anxiety symptoms behavior measurement behavioral outcome brain behavior brain research critical period data collection site delivery complications demographics design epidemiology study executive function fetal fetal blood fetal drug exposure fetal marijuana exposure health care availability high risk population human fetal brain hypothalamic-pituitary-adrenal axis impression in utero indexing male marijuana legalization marijuana use marijuana use in pregnancy maternal anxiety maternal depression mesolimbic system migration mood symptom neural neurodevelopment neurodevelopmental effect neuroimaging novel offspring postnatal pre-clinical premature prenatal prenatal exposure receptor expression sex substance use synaptogenesis tertiary care tool young adult

项目摘要

PROJECT SUMMARY Current estimates suggest that in North America over 7% of women use cannabis during pregnancy and this use is increasing as legalization becomes more common. Despite the high prevalence of prenatal cannabis exposure, its effects on early brain and behavioral development remain poorly characterized, leaving some with the impression that this exposure is benign or potentially even beneficial (e.g., to treat nausea during pregnancy). Prior neurodevelopmental research on prenatal cannabis effects have had been important limitations including few if any brain/behavioral assessments during first two years of life (a period critical to neurodevelopment), poor characterization of the post-natal environment, and limited assessments of pre- and post-natal maternal mood and anxiety, thus confounding interpretation of prenatal cannabis effects. In our study, we will enroll pregnant women with (n=300) and without a history (n=150) of cannabis use during the first trimester gestation and follow their offspring for the first two years of life with a focus on the neurodevelopment of executive functions. First, we will characterize prenatal cannabis use through pregnancy with self-report measures and biospecimens. Second, we will obtain third trimester fetal MRI scans to character offspring brain structure and function free of post-natal confounds. Third, we will assess offspring cognitive and behavioral development over the first two years of life with parent-report and laboratory-based behavioral assessments. Our design considers critical confounds including parent-infant interactions, pre- and postnatal maternal mood and anxiety symptoms, shared genetic liability, and concomitant drug use during pregnancy. Given the lack of clarity on the safety of cannabis use during pregnancy, findings from this study will have important public health implications by informing prevention messaging and strategies particularly in this era of increasing cannabis use.

项目摘要目前的估计表明，在怀孕期间，超过7％的妇女使用大麻，这随着合法化变得越来越普遍，使用正在增加。尽管产前大麻的患病率很高暴露，其对早期大脑和行为发展的影响的特征仍然很差，使一些人伴有这种暴露是良性或可能有益的印象（例如，在怀孕期间治疗恶心）。先前关于产前大麻作用的神经发育研究一直是重要的局限性在生命的头两年（这对神经发育至关重要的时期），很少有大脑/行为评估产后环境的表征，以及对产后和后产妇情绪的有限评估和焦虑，从而混淆了对产前大麻作用的解释。在我们的研究中，我们将入学（n = 300）且没有病史（n = 150）大麻使用的妇女在孕期使用他们的后代在生命的头两年，重点是执行功能的神经发育。第一的，我们将通过自我报告措施和生物测量来表征通过怀孕的产前大麻使用。其次，我们将获得三个月的胎儿MRI扫描到特征后代大脑结构和功能不含的功能产后混杂。第三，我们将在前两个评估后代认知和行为发展父母报告和基于实验室的行为评估的生命年。我们的设计认为关键混杂在内的混杂，包括父母的互动，产前和产后的母亲情绪和焦虑症状，共享遗传责任和怀孕期间的毒品使用。鉴于缺乏大麻安全性在怀孕期间使用，这项研究的发现将通过通知来具有重要的公共卫生影响预防消息传递和策略，尤其是在大麻使用越来越多的时代。