Prenatal cannabis: A fetal neuroimaging study of neurodevelopment
产前大麻:神经发育的胎儿神经影像学研究
基本信息
- 批准号:10317882
- 负责人:
- 金额:$ 62.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescentAffectAlcoholsAnxietyAttention deficit hyperactivity disorderAttenuatedAutopsyBehavior assessmentBehavioralBenignBindingBlood - brain barrier anatomyBrainCNR1 geneCanadaCannabisChildCigaretteCocaineCognitiveCollaborationsCorpus striatum structureDataDevelopmentDopamineDrug usageEnrollmentEnvironmentEnvironmental Risk FactorExecutive DysfunctionExposure toFamilyFemaleFirst Pregnancy TrimesterFunctional Magnetic Resonance ImagingFutureGeneticHealth PolicyHealthcare SystemsHigh PrevalenceHome environmentHumanInfantInfant BehaviorInterventionLaboratoriesLegalLifeLinkMRI ScansMagnetic Resonance ImagingMeasuresMediatingMedical centerMinnesotaMoodsMothersNauseaNeuronsNorth AmericaOpioidOutcomeParentsPatient Self-ReportPerinatalPharmaceutical PreparationsPhenotypePlacentaPostpartum PeriodPredispositionPrefrontal CortexPregnancyPregnant WomenPrenatal carePreventionPrevention strategyPsychosesPublic HealthQuebecRecording of previous eventsReportingResearchRiskRodentSafetySpecificityStressStructureSubstance of AbuseTeenagersTetrahydrocannabinolThird Pregnancy TrimesterUniversitiesWithdrawal SymptomWomananxiety symptomsbasebehavior measurementbehavioral outcomebrain behaviorbrain researchcritical perioddata collection sitedelivery complicationsdemographicsdesignepidemiology studyexecutive functionfetalfetal bloodfetal drug exposurefetal marijuana exposurehealth care availabilityhigh risk populationhuman fetal brainhypothalamic-pituitary-adrenal axisimpressionin uteroindexingmalemarijuana legalizationmarijuana usemarijuana use in pregnancymaternal anxietymaternal depressionmesolimbic systemmigrationmood symptomneurodevelopmentneurodevelopmental effectneuroimagingnoveloffspringpostnatalpre-clinicalprematureprenatalprenatal exposurereceptor expressionrelating to nervous systemsexsubstance usesynaptogenesistertiary caretoolyoung adult
项目摘要
PROJECT SUMMARY
Current estimates suggest that in North America over 7% of women use cannabis during pregnancy and this
use is increasing as legalization becomes more common. Despite the high prevalence of prenatal cannabis
exposure, its effects on early brain and behavioral development remain poorly characterized, leaving some with
the impression that this exposure is benign or potentially even beneficial (e.g., to treat nausea during pregnancy).
Prior neurodevelopmental research on prenatal cannabis effects have had been important limitations including
few if any brain/behavioral assessments during first two years of life (a period critical to neurodevelopment), poor
characterization of the post-natal environment, and limited assessments of pre- and post-natal maternal mood
and anxiety, thus confounding interpretation of prenatal cannabis effects. In our study, we will enroll pregnant
women with (n=300) and without a history (n=150) of cannabis use during the first trimester gestation and follow
their offspring for the first two years of life with a focus on the neurodevelopment of executive functions. First,
we will characterize prenatal cannabis use through pregnancy with self-report measures and biospecimens.
Second, we will obtain third trimester fetal MRI scans to character offspring brain structure and function free of
post-natal confounds. Third, we will assess offspring cognitive and behavioral development over the first two
years of life with parent-report and laboratory-based behavioral assessments. Our design considers critical
confounds including parent-infant interactions, pre- and postnatal maternal mood and anxiety symptoms, shared
genetic liability, and concomitant drug use during pregnancy. Given the lack of clarity on the safety of cannabis
use during pregnancy, findings from this study will have important public health implications by informing
prevention messaging and strategies particularly in this era of increasing cannabis use.
项目摘要
目前的估计表明,在北美,超过7%的妇女在怀孕期间使用大麻,
随着合法化越来越普遍,使用也越来越多。尽管产前大麻的流行率很高,
暴露,其对早期大脑和行为发育的影响仍然很难描述,
这种暴露是良性的或甚至可能有益的印象(例如,治疗妊娠期恶心)。
以前关于产前大麻影响的神经发育研究一直存在重要的局限性,
在生命的前两年(神经发育的关键时期),很少(如果有的话)进行大脑/行为评估,
对产后环境的描述,以及对产前和产后母亲情绪的有限评估
和焦虑,从而混淆产前大麻影响的解释。在我们的研究中,我们将招募妊娠
在妊娠前三个月和随后三个月期间有(n=300)和无大麻使用史(n=150)的女性
他们的后代在生命的头两年,重点是执行功能的神经发育。第一、
我们将通过自我报告措施和生物标本来描述产前大麻使用情况。
第二,我们将获得第三个三个月的胎儿MRI扫描,以表征后代的大脑结构和功能,
产后混乱第三,我们将评估前两种情况下后代的认知和行为发展。
年的生活与父母的报告和实验室为基础的行为评估。我们的设计考虑到了
包括父母-婴儿互动,产前和产后母亲情绪和焦虑症状,共享
遗传易感性和妊娠期间合并用药。鉴于大麻的安全性尚不明确,
在怀孕期间使用,这项研究的结果将通过告知
预防信息和战略,特别是在大麻使用日益增加的时代。
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
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{{ truncateString('Claudia I Lugo-Candelas', 18)}}的其他基金
Prenatal air pollution and neurodevelopment: a longitudinal neuroimaging study of mechanisms and early risk for ADHD in Puerto Rican children
产前空气污染和神经发育:波多黎各儿童 ADHD 机制和早期风险的纵向神经影像研究
- 批准号:
10647635 - 财政年份:2022
- 资助金额:
$ 62.25万 - 项目类别:
Prenatal air pollution and neurodevelopment: a longitudinal neuroimaging study of mechanisms and early risk for ADHD in Puerto Rican children
产前空气污染和神经发育:波多黎各儿童 ADHD 机制和早期风险的纵向神经影像研究
- 批准号:
10366304 - 财政年份:2022
- 资助金额:
$ 62.25万 - 项目类别:
Prenatal cannabis: A fetal neuroimaging study of neurodevelopment
产前大麻:神经发育的胎儿神经影像学研究
- 批准号:
10653949 - 财政年份:2021
- 资助金额:
$ 62.25万 - 项目类别:
A longitudinal study of prenatal maternal obesity and the fetal origins of impulsivity in Puerto Rican children
波多黎各儿童产前肥胖和胎儿冲动起源的纵向研究
- 批准号:
10583286 - 财政年份:2019
- 资助金额:
$ 62.25万 - 项目类别:
A longitudinal study of prenatal maternal obesity and the fetal origins of impulsivity in Puerto Rican children
波多黎各儿童产前肥胖和胎儿冲动起源的纵向研究
- 批准号:
9883841 - 财政年份:2019
- 资助金额:
$ 62.25万 - 项目类别:
A longitudinal study of prenatal maternal obesity and the fetal origins of impulsivity in Puerto Rican children
波多黎各儿童产前肥胖和胎儿冲动起源的纵向研究
- 批准号:
10610973 - 财政年份:2019
- 资助金额:
$ 62.25万 - 项目类别:
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