A longitudinal study of prenatal maternal obesity and the fetal origins of impulsivity in Puerto Rican children

波多黎各儿童产前肥胖和胎儿冲动起源的纵向研究

• 批准号: 10610973
• 负责人: Claudia I Lugo-Candelas
• 金额: $ 18.97万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10610973
• 关键词: 2 year old; Age; Animal Experimentation; Attention deficit hyperactivity disorder; Authorization documentation; Award; Behavior; Behavior assessment; Behavioral; Biological Markers; Biometry; Body mass index; Brain; C-reactive protein; Child; Child Health; Childhood; Collection; Communities; Conceptions; Data; Data Collection; Development; Disease; Dopamine; Ensure; Environment; Epidemiology; Equipment and supply inventories; Ethnic Origin; Ethnic Population; Exposure to; Fostering; Functional Magnetic Resonance Imaging; Future; Generations; Goals; Hispanic; Human; Impairment; Impulsivity; Infant; Infection; Inflammation; Interleukin-6; Intervention; Latino Population; Life Cycle Stages; Life course epidemiology; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediating; Mediator; Mental disorders; Mentorship; Monitor; Mothers; National Institute of Mental Health; Newborn Infant; Not Hispanic or Latino; Nursery Schools; Obesity; Outcome Study; Parents; Perinatal; Physical activity; Population; Population Heterogeneity; Pregnancy; Pregnant Women; Prevalence; Prevention; Puerto Rican; Reporting; Research; Research Personnel; Rest; Risk; Role; Sampling; Signal Transduction; Structure; Symptoms; Testing; Third Pregnancy Trimester; Toddler; Training; United States National Institutes of Health; Ventral Striatum; Weight; Woman; Work; Youth; authority; behavior measurement; career development; cohort; disorder control; early childhood; epidemiology study; executive function; experience; fetal; follow up assessment; indexing; infancy; interdisciplinary approach; intergenerational; intrauterine inflammation; maternal obesity; neural circuit; neurodevelopment; neuroimaging; nutrition; offspring; participant enrollment; phenomenological models; postnatal; prenatal; prenatal exposure; prenatal influence; prepregnancy; programs; prospective; racial minority population; sex; skills; transmission process

PROJECT SUMMARY This K08 application aims at examining a potential fetal origin of inhibitory control difficulties: in utero exposure to prenatal maternal obesity. This study fills a crucial gap by examining inhibitory control deficits in an intergenerational sample of Puerto Ricans in the US. This community, alongside other Latino populations, has seen an increase in obesity and impulsivity-related disorders such as attention-deficit/hyperactivity disorder (ADHD), yet remains vastly understudied. This five-year K08 application presents a program for research and training that will support the applicant on a path towards becoming an independent investigator, focused on studying the early origins of inhibitory control deficits through an interdisciplinary approach (life course epidemiology, infant neuroimaging, and biostatistics). The training plan builds on the candidate's prior training and experience and capitalizes on an outstanding mentorship team and research environment to foster the development of the candidate's expertise in (1) collection, analysis, and interpretation of infant resting state functional Magnetic Resonance Imaging (fMRI) data; (2) perinatal weight and inflammation and its relationship to fetal neurodevelopment; (3) life course epidemiologic research with ethnic/racial minority populations; (4) phenomenology and assessment of inhibitory control in toddlers; and (5) responsible conduct in scientific research. This project will investigate the influence of high maternal prenatal body mass index (BMI) on frontostrialal connectivity (i.e., circuits implicated in inhibitory control disorders) in offspring infants (Aim #1) and on behavioral assessments of inhibitory control at age 2 (Aim # 2). It is hypothesized that inflammation is a key mediator (i.e. mechanism) by which maternal prenatal BMI leads to disruptions in frontostriatal connectivity in infants and impaired inhibitory control in toddlers. The project will collect prenatal assessments of maternal BMI and inflammation, resting state fMRI data from infants at 2-4 weeks of age, and behavioral and parent report measures of inhibitory control abilities at age 2. Currently, the proposed study participants are enrolled in the NIH Environmental influences on Child Health Outcomes (ECHO) study, which will collect MRI data on 500 infants. Building on this structure, we propose to select a subsample (n=76) of average (BMI=18.5– 24.9 kg m−2; n=38) and obese (BMI?30 kg m−2; n=38) pregnant women and offspring to include in this project. Data yielded from the proposed study will lead to a future R01 application examining offspring's inhibitory control circuits longitudinally. Together, the research and training experiences and expertise developed through this K08 award will support the applicant's transition to research independence and ensure the applicant becomes a leading authority in the prenatal origins of inhibitory control deficits.

项目摘要 该K08应用旨在检查抑制性控制难度的潜在胎儿起源：在子宫内暴露 产前产妇肥胖。这项研究通过检查在 美国波多黎各人的代际样本。这个社区以及其他拉丁裔人口都有 看到肥胖和冲动性相关疾病的增加，例如注意力缺陷/多动症障碍 （多动症），但仍然非常了解。该五年的K08应用程序介绍了一项研究计划， 培训将支持申请人成为一名独立研究者的道路，专注于 研究抑制控制的早期起源是通过跨学科方法（生命过程）定义的 流行病学，婴儿神经影像学和生物统计学）。培训计划以候选人的先前培训为基础 和经验并利用杰出的精明团队和研究环境，以促进 候选人在（1）收集，分析和解释婴儿休息状态方面的专业知识的发展 功能磁共振成像（fMRI）数据； （2）围产期体重和注射及其关系 胎儿神经发育； （3）生活课程的流行病学研究与种族/种族少数群体； （4） 现象学和评估幼儿中的抑制性控制； （5）科学的负责任行为 研究。该项目将调查高母生产前体重指数（BMI）对 后代婴儿的额叶连通性（即在抑制性控制障碍中实施的圆圈）（AIM＃1）和 在2岁时对抑制性控制的行为评估（AIM＃2）。假设注射是关键 介体（即机制）通过该介体导致额叶连通性的中断。 婴儿和幼儿抑制控制受损。该项目将收集产妇的产前评估 BMI和注射，2-4周龄的基础设施的静止状态fMRI数据以及行为和父母 报告2岁时抑制性控制能力的报告。目前，拟议的研究参与者已招募 在NIH环境对儿童健康结果的影响（ECHO）研究中，该研究将收集有关MRI数据 500名婴儿。在此结构的基础上，我们建议选择平均值的子样本（n = 76）（BMI = 18.5 – – 24.9 kg m -2; n = 38）和肥胖（BMI？30 kg m -2; n = 38）孕妇和后代，将其包括在该项目中。 拟议的研究产生的数据将导致未来的R01申请检查后代的抑制 纵向控制电路。共同发展的研究和培训经验和专业知识 通过这项K08奖，将支持申请人对研究独立性的过渡，并确保 申请人成为抑制性控制缺陷产前起源的领先权威。