Core A: Administrative/Clinical/Bioinformatics Core

行政/临床/生物信息学核心(核心A)：摘要 行政/临床/生物信息学核心的总体目标是提供财政、 为每个项目提供行政、临床材料和数据访问、生物信息和统计支持 和此计划项目中的核心。 行政/临床/生物信息学核心有行政和科学任务，将支持 这个PPG的目标和人员。该核心将负责支持所有行政工作 PPG，集中访问未确认的临床样本和相关临床数据库，并协调 PPG成员的生物统计和信息学分析，包括协助微生物组成 对PPG内的项目进行分析。行政职责包括协调NIH的所有互动， 包括组装和准备本申请，协调年度非竞争性续签相关事宜 提交，以及所有其他与NIH相关的互动。该核心还将发挥统一和协调各项活动的作用。 在计划项目参与者中，包括组织每月会议，以及所有内部和 外部评论。这个核心的另一个主要功能是促进和协调合作研究 通过使用与临床数据库、生物信息学和生物信息学共享的临床资源，在PPG内开展活动 统计数据支持。最后，这个核心将有助于协调整个地区的微生物群落组成分析 PPG。因此，这一核心将促进本方案的组织和行政管理， 协调计划内的沟通，监控项目的进展，确保有效使用 提供关键的临床、数据库、生物信息学和统计支持。

Administrative/Clinical/Bioinformatics Core (Core A): Abstract The overall goals of the Administrative/Clinical/Bioinformatics Core are to provide fiscal, administrative, clinical material and data access, bioinformatic and statistics support to each Project and Core within this Program Project. The Administrative/Clinical/Bioinformatics Core has both administrative and scientific missions that will support the goals and personnel of this PPG. This core will be responsible for supporting all administrative efforts for the PPG, centralizing access to de-identified Clinical samples and related clinical databases, and coordinating biostatistics and informatics analyses for PPG members, including assistance in microbial composition analyses for the Projects within the PPG. Administrative duties include coordination of all NIH interactions, including assembly and preparation of this application, coordination of annual non-competitive renewal related submissions, and all other NIH related interactions. This core will also function to unify and coordinate activities amongst the Program Project participants, including organization of monthly meetings, and all internal and external reviews. Another major function of this core will be to foster and coordinate collaborative research activities within the PPG through use of shared clinical resources with clinical database, bioinformatics and statistics support. Finally, this core will help coordinate microbial community composition analyses across the PPG. Thus, this core will facilitate the organizational and administrative management of the Program, orchestrating communication within the Program, monitoring of progress in the Projects, ensuring effective use of the shared resource cores, and provide key clinical, database, bioinformatics and statistical support.