Central Africa International Epidemiology databases to Evaluate AIDS

中部非洲国际流行病学数据库评估艾滋病

• 批准号: 10403580
• 负责人: Kathryn M. Anastos
• 金额: $ 305万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10403580
• 关键词: AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent and Young Adult; Adult; Africa South of the Sahara; African; Age; Aging; Alcohols; Area; Automobile Driving; Biological; Burundi; Cameroon; Cardiovascular Diseases; Caring; Central Africa; Cessation of life; Child; Childhood; Climate; Clinic; Clinical; Clinical Research; Collaborations; Collection; Congo; Consensus; Continuity of Patient Care; Country; Data; Data Collection; Databases; Democratic Republic of the Congo; Development; Diagnosis; Disease; Elderly; Enrollment; Epidemiology; Fostering; Funding; HIV; HIV diagnosis; HIV-infected adolescents; HIV/TB; Health; Hypertension; Impairment; Incidence; Infant; International; Investigation; Kidney Diseases; Knowledge; Lead; Leadership; Link; Longitudinal cohort; Maternal and Child Health; Mental Health; Mentors; Mentorship; Methods; Mission; Modeling; Monitor; Morbidity - disease rate; Mothers; Outcome; Pathway interactions; Persons; Policies; Policy Maker; Positioning Attribute; Pregnant Women; Public Health; Publications; Recurrence; Research; Research Personnel; Research Priority; Resources; Risk; Rwanda; Sentinel; Services; Site; Time; Treatment outcome; Tuberculosis; Ursidae Family; Viral; Work; antiretroviral therapy; care outcomes; career; clinical investigation; cohort; comorbidity; design; disorder risk; epidemiology study; follow-up; implementation research; implementation science; implementation strategy; improved; innovation; mortality; next generation; pediatric human immunodeficiency virus; pharmacovigilance; pre-exposure prophylaxis; prevent; programs; psychosocial; pulmonary function; service delivery; service utilization; social stigma; substance use; success; transmission process; treatment program; tuberculosis treatment

Project Summary As HIV care and treatment programs are implemented throughout sub-Saharan Africa (SSA), critical advances in research and policy are needed so that care and treatment resources can be deployed to optimal benefit: decreasing new HIV transmissions, HIV-related morbidity and mortality, and illness from non-communicable disease (NCD). Coverage of antiretroviral therapy in the 'Treat All' era varies widely in our region, from 87% in Rwanda to 25% in Republic of Congo, the lowest coverage among all IeDEA countries in SSA. Our research agenda is designed to generate actionable knowledge to help close these gaps. Our regional cohort database includes longitudinal data for 81,183 adults and 11,789 children ever enrolling in HIV care at 22 sites in Burundi, Cameroon, the Democratic Republic of Congo, Republic of Congo and Rwanda. We propose to supplement this database with linked cohorts to address a range of investigations relevant to our region including: 1) leveraging implementation science approaches to inform strategies aimed at improving HIV prevention, care and treatment outcomes in the region (Aim 1); 2) conducting in-depth clinical investigations of HIV-related outcomes and infectious (e.g. TB) and non-infectious (e.g. NCDs) comorbidities (Aim 2); 3) leading and supporting an innovative multiregional scientific agenda within the larger IeDEA network (Aim 3); and 4.) providing scientific and career mentoring to early stage investigators and researchers from Central Africa and from the US (Aim 4). Central Africa IeDEA has a diverse scientific team with broad and deep expertise in implementation science, epidemiology and clinical research. We have been highly productive scientifically with >45 publications across a range of topics, and have continued to foster African leadership and build local research capacity. Themes in our application include an emphasis on ‘treat all’ policy implementation, mental health and substance use (alcohol), PMTCT and pediatric and adolescent HIV, tuberculosis, HIV prevention through PrEP, and NCDs in aging people living with HIV (e.g. kidney disease).

项目概要 随着艾滋病毒护理和治疗计划在整个撒哈拉以南非洲 (SSA) 实施， 需要在研究和政策方面取得重大进展，以便护理和治疗资源能够 部署以获得最佳效益：减少新的艾滋病毒传播、艾滋病毒相关发病率和 死亡率和非传染性疾病 (NCD) 引起的疾病。抗逆转录病毒治疗的覆盖范围 我们地区的“对待所有人”时代差异很大，从卢旺达的 87% 到共和国的 25% 刚果是 SSA 中所有 IeDEA 国家中覆盖率最低的。我们的研究议程是 旨在产生可操作的知识来帮助缩小这些差距。我们的区域队列 数据库包括 81,183 名成人和 11,789 名儿童的纵向数据 在布隆迪、喀麦隆、刚果民主共和国、刚果共和国的 22 个地点提供护理 和卢旺达。我们建议用链接的队列来补充该数据库，以解决一系列问题 与我们地区相关的调查包括：1) 利用实施科学 为旨在改善艾滋病毒预防、护理和治疗的战略提供信息的方法 该地区的成果（目标 1）； 2）深入开展HIV相关的临床调查 结果以及传染性（例如结核病）和非传染性（例如非传染性疾病）合并症（目标 2）； 3） 在更大的 IeDEA 内领导和支持创新的多区域科学议程 网络（目标 3）； 4.) 为早期研究人员提供科学和职业指导 以及来自中非和美国的研究人员（目标 4）。中非 IeDEA 有一个 多元化的科学团队，在实施科学、流行病学方面拥有广泛而深厚的专业知识 和临床研究。我们在科学方面一直保持着极高的生产力，在各个领域发表了超过 45 篇出版物 一系列主题，并继续培养非洲领导力并建立本地研究 容量。我们应用程序的主题包括强调“对待所有人”政策的实施， 心理健康和药物滥用（酒精）、预防母婴传播以及儿科和青少年艾滋病毒， 结核病、通过 PrEP 预防艾滋病毒以及老年艾滋病毒感染者的非传染性疾病（例如艾滋病毒感染者） 肾脏疾病）。