Einstein/Rwanda/DRC Consortium for Research in HIV/HPV Malignancies

摘要 在这份U54报告中，我们建议建立一个HPV/HIV相关恶性肿瘤研究中心 (HAMRC)作为刚果民主共和国卢旺达的机构和调查人员的伙伴关系 刚果(金)和美国(美国)，综合、跨学科的重点是 HIV/HPV相关的恶性肿瘤。HAMRC计划拥有一个协调的和 人乳头瘤病毒相关研究和能力建设综合方案(发展核心) PLWH的癌症。发展核心的目标是培养一支初级和中级干部队伍 将利用中心开发的资源来催化研究的级别研究人员 卢旺达和刚果民主共和国与HPV/艾滋病毒相关的恶性肿瘤。 初级和中级研究人员的发展将通过学徒制度来完成 在这种模式下，他们与开发和开发方面经验丰富的调查员配对 执行研究方案或试点项目。指导将分别为每个人量身定制 实习生，建立在他或她以前的培训、研究经验、兴趣和研究的基础上 项目。此外，还将利用同行评审的试点赠款计划来刺激 制定专门针对HPV/HIV相关癌症的研究项目。这个 Development Core将由三名非洲调查人员领导，他们都是独立资助的 因此，研究人员为EIS提供了经历过类似于 他们自己值得效仿/学习的强大榜样。除了核心董事外，还有一个团队 导师将在主要研究项目和潜在的试点项目中与学员合作

ABSTRACT In this U54, we propose to establish an HPV/HIV-Associated Malignancy Research Center (HAMRC) as a partnership of institutions and investigators in Rwanda, the Democratic Republic of Congo (DRC) and the United States (US), with an integrated, trans-disciplinary focus on HIV/HPV-associated malignancies. The HAMRC is planned to have a coordinated and integrated program of research and capacity-building (Developmental Core) in HPV-related cancers in PLWH. The aim of the Developmental Core is to develop a cadre of junior and mid- level researchers who will utilize the resources developed by the Center to catalyze research in HPV/HIV-associated malignancies in Rwanda and the Democratic Republic of Congo (DRC). This development of junior and mid-level researchers will be done through an apprenticeship model in which they are paired with an experienced investigator in the development and execution of a research protocol or a pilot project. Mentoring will be individually tailored for each trainee, building on his or her prior training, research experience, interests and research projects. In addition, a peer-reviewed pilot grants program will be utilized to stimulate development of research projects specifically in HPV/HIV associated cancers. The Developmental Core will be led by three African investigators who are all independently funded researchers, thus, providing the ESIs with role models who have navigated challenges similar to their own and strong examples to follow/learn from. In addition to the Core Directors, a team of mentors will work with the trainees in the major research projects and potential pilot projects