California National Primate Research Center

概述 摘要 位于加州大学戴维斯分校的加州国家灵长类动物研究中心（CNPRC）， 申请资金，在未来五年内（2018年5月1日）更新基本运营补助金#P51-OD 011107 至2023年4月30日）。目前，在第56个年头的运作，CNPRC提供了一系列NIH支持的 全国范围内的调查人员和行业合作伙伴。从成立到本年度，CNPRC一直 通过提供高质量的动物、设施、工具和服务，高度响应研究界的要求 由核心科学家的知识基础设施驱动，为我们的使命服务：“改善人类健康， 健康和生活质量，通过特殊的非人类灵长类动物研究计划的支持”。的目标 下一个资助期体现在以下具体目标：（1）进行最先进的研究， 科学上有助于理解和治疗人类疾病的非人类灵长类动物模型 （2）为研究人员提供特殊的非人灵长类动物专业知识和服务， 地方，地区和国家层面，以推进NIH支持的卓越研究，（3）指导和培训 具有非人类灵长类专业知识的下一代翻译研究人员，以及（4）确保最高的 负责任地进行研究和动物护理的标准。我们将继续强调团队科学 针对整个生命周期的主要人类健康问题，目标是超越传统的 跨学科的努力，以真正的研究问题正在解决的趋同。请求提供支助， 行政事务处（主任办公室、行政和业务处、信息技术处） 服务，设施改善），灵长类动物服务（殖民地管理和研究服务，国家 老龄群体研究所，灵长类医学服务，解剖和临床病理学服务，人口和 行为健康服务、遗传学管理服务）、服务核心（流式细胞术、吸入 暴露，多模式成像，灵长类动物检测实验室），科学研究单位（传染病， 神经科学和行为，生殖科学和再生医学，呼吸系统疾病），并为 外联、试点研究方案和NPRC联合会活动。我们的终极目标是 通过CNPRC的临床前项目以及合作团队产生转化影响 在当地、全国和全球范围内推广。我们致力于开发和提供广泛的 最大限度地利用非人类灵长类动物模型来改善人类健康的研究机会。的 加州大学戴维斯分校对CNPRC的机构承诺得到了加强，这将有助于我们 在将非人类灵长类动物研究带入下一个融合生物医学研究时代方面发挥着重要作用。

OVERVIEW ABSTRACT The California National Primate Research Center (CNPRC), located at the University of California, Davis, requests funds to renew the base operating grant #P51-OD011107 for the next five year period (May 1, 2018 through April 30, 2023). Currently in the 56th year of operation, the CNPRC serves a range of NIH-supported investigators and industry partners nationwide. From inception through the current year, the CNPRC has been highly responsive to the research community by providing high quality animals, facilities, tools, and services driven by the intellectual infrastructure of the Core Scientists in the service of our Mission: “To improve human health and quality of life through support of exceptional nonhuman primate research programs”. The goals for the next funding period are reflected in the following Specific Aims: (1) Conduct state-of-the-art research and scientifically contribute to the understanding and treatment of human disease with nonhuman primate models across the age spectrum, (2) Provide exceptional nonhuman primate expertise and services to investigators at the local, regional, and national levels to advance NIH-supported research excellence, (3) Mentor and train the next generation of translational investigators with nonhuman primate expertise, and (4) Ensure the highest standards of responsible conduct of research and animal care. We will continue to emphasize team science aimed at major human health problems across the lifespan, with the goal of moving beyond traditional interdisciplinary efforts to true convergence on the research problems being addressed. Support is requested for Administrative Services (Director's Office, Administration and Operations Services, Information Technology Services, Facilities Improvement), Primate Services (Colony Management and Research Services, National Institute on Aging Colony, Primate Medicine Services, Anatomic and Clinical Pathology Services, Population and Behavioral Health Services, Genetics Management Services), Service Cores (Flow Cytometry, Inhalation Exposure, Multimodal Imaging, Primate Assay Laboratory), Scientific Research Units (Infectious Diseases, Neuroscience and Behavior, Reproductive Sciences and Regenerative Medicine, Respiratory Diseases), and for Outreach, the Pilot Research Program, and NPRC Consortium activities. Our over-arching goal is to achieve translational impact through preclinical programs housed at the CNPRC as well as through collaborative teams that reach out locally, nationally, and globally. We are committed to developing and providing a wide range of research opportunities that maximize use of the nonhuman primate model to improve human health. The institutional commitment from UC Davis to the CNPRC has been reinforced in a manner that will facilitate our role in moving nonhuman primate research into the next era of convergent biomedical research.