BioBehavioral Assessment (BBA)

灵长类动物服务：生物行为评估 摘要 我们独特的发育和生物行为构成会影响我们患病的风险和 医疗干预是精准医疗的关键概念。越来越明显的是，生物医学 疾病模型必须考虑到个体差异，以实现与人类健康的最大可转换性 research.加州国家灵长类动物研究所的生物行为评估（BBA）项目 中心（CNPRC），于2001年推出，已经量化了生物行为组织的措施（即， 气质，生理反应，遗传学）在超过5000个婴儿恒河猴的日期。BBA有 为70多篇出版物提供了基础，并为人类的重要发现做出了贡献。 健康和疾病的发展根源（例如，哮喘、自闭症、抑郁症和腹泻）。BBA已经 被我们的国家科学顾问委员会确定为CNPRC的重点研究资源， 补助金审查。该计划的目标有三个：1）全面清查个人 猕猴生物行为组织，并将这些信息与健康结果联系起来; 2）制作数据 可用作科学探究的资源（例如，（3）为选择主题做出贡献; 知识和改善非人类灵长类动物资源在我们自己的中心，并通过我们的 发表的研究，提供了重要的信息，管理人员在其他灵长类动物设施在美国 国家也是。在此修订的P51申请中，将BBA作为CNPRC动物资源，我们建议 优化这个特殊的计划与新的愿景，以推动BBA资源进入下一个十年的NHP research.这四个层次的愿景包括：1。从历史BBA数据开发新的结构来预测 健康与疾病（2）在CNPRC研究中采用纵向健康跨度方法， 将BBA与我们的NIA老年医学研究计划联系起来3.）增加资源的用户群， PI的咨询和定制测试选项，以及4.）使BBA数据普遍可访问， 开发和测试互动教育和数据共享网站，分三年完成 阶段，于2020年公开，并于2022年完成。预计新的BBA研究方向和 可访问性将在科学发现和公众对生物行为的理解方面产生巨大的飞跃， 在NHP发展中。

PRIMATE SERVICES: BIOBEHAVIORAL ASSESSMENT ABSTRACT Our unique developmental and biobehavioral makeup affects our risk for disease and the effectiveness of medical intervention, a key concept in precision medicine. It is becoming increasingly clear that biomedical models of disease must account for individual variation to achieve peak translatability with human health research. The BioBehavioral Assessment (BBA) Program at the California National Primate Research Center (CNPRC), launched in 2001, has quantified measures of biobehavioral organization (i.e., temperament, physiological reactivity, genetics) in more than 5000 infant rhesus monkeys to date. BBA has provided the basis for more than 70 publications and has contributed important discoveries on the developmental roots of health and disease (e.g., asthma, autism, depression, and diarrhea). BBA has been identified as a keystone CNPRC research resource by our National Scientific Advisory Board and in base grant reviews. The goals of this program have been threefold: 1) to comprehensively inventory individual macaque biobehavioral organization and relate this information to health outcomes; 2) to make data available as a resource for scientific inquiry (e.g., for subject selection); and 3) to contribute to the knowledge and improvement of the nonhuman primate resource at our own center, and through our published studies, provide important information to management staff at other primate facilities in the United States as well. In this revised P51 application to embed BBA as a CNPRC animal resource, we propose to optimize this exceptional program with a new vision to propel the BBA resource into the next decade of NHP research. This four-tiered vision includes: 1.) Developing new constructs from historical BBA data to predict health and disease, 2.) stimulating a longitudinal health span approach in CNPRC research, by formally linking BBA with our NIA geriatric research program 3.) increasing user ship of the resource by offering consulting and custom testing options for PIs, and 4.) making BBA data universally accessible by developing and beta testing an interactive educational and data sharing website to be completed in three phases, made public in 2020 and completed by 2022. It is anticipated that new BBA research directions and accessibility will yield a large leap forward in scientific discovery and public understanding of biobehavioral organization in NHP development.