Natural variation and genetic basis of dengue virus transmission rate in Australian mosquitoes

当受感染的旅行者进入澳大利亚并被当地蚊子叮咬时，澳大利亚就会爆发登革热。在这里，我们研究了蚊子和传入的登革热病毒之间的遗传相容性程度，这可能会影响人类的疾病风险。我们将确定蚊子的基因，确定昆虫的传播登革热病毒的能力，并制定一个地理传播地图的范围内不同的登革热菌株在澳大利亚人口的昆虫。

Dengue fever outbreaks occur in Australia when infected travelers enter the country and are bitten by local mosquitoes. Here we examine the degree of genetic compatibility between mosquitoes and incoming dengue viruses that may affect disease risk for humans. We will identify the mosquito genes that determine the insect’s capacity to transmit dengue virus and develop a geographic map of transmissibility for a range of different dengue strains across Australian populations of the insect.