Core A: Administrative Core

行政核心摘要 行政核心将支持阿尔茨海默氏症生物标记物联合会-唐氏综合症的整体工作 (ABC-DS)，包括8个临床绩效站点、7个核心、3个研究项目和7个 研究分包商。核心员工将组织和协调各个部门的活动和沟通 这些组件。这将包括提供行政和预算支助以及监测、安排 和组织会议，并与ABC-DS指导委员会密切合作，以制定政策和 程序，描述方案，监测招募，并跟踪生物标本的收集、传播和 储藏室。在与神经成像核心的合作下，工作人员将协调FDA的所有监管要求 与PET放射性药物生产相关。最后，行政核心将向ABC提供支持-- DS出版和辅助研究委员会和ABC-DS生物标本委员会，组织年度NIA 提交进度报告和两年两次的数字和通信设备管理局报告，并与中央信息和通信技术中心密切合作。

Administrative Core Abstract The Administrative Core will support the overall work of the Alzheimer Biomarker Consortium-Down Syndrome (ABC-DS), which includes eight Clinical Performance sites, seven Cores, three Research Projects and seven research subcontractors. Core staff will organize and coordinate activities and communication across each of these components. This will include providing administrative and budgetary support and monitoring, arranging and organizing meetings, and working closely with the ABC-DS Steering Committee to establish policies and procedures, delineate protocols, monitor recruitment, and track bio-specimen collection, dissemination and storage. In collaboration with the Neuroimaging Core, staff will coordinate all FDA regulatory requirements related to PET radiopharmaceutical production. Finally, the Administrative Core will provide support to the ABC- DS Publications and Ancillary Studies Committee and ABC-DS Bio-specimen Committee, organize annual NIA progress reports and twice-annual DSMB reports, and work closely with the Central IRB.