Core A: Administrative Core

行政核心摘要 行政核心将支持阿尔茨海默氏症生物标志物联盟-唐氏综合征的整体工作 （ABC-DS），其中包括8个临床性能研究中心、7个核心研究中心、3个研究项目和7个 研究分包商核心工作人员将组织和协调活动和沟通， 这些组件。这将包括提供行政和预算支助以及监测、安排 组织会议，并与ABC-DS指导委员会密切合作，制定政策， 程序，描述协议，监测招募，并跟踪生物标本的收集，传播和 存储.与神经影像学中心合作，工作人员将协调所有FDA监管要求 与PET放射性药物生产有关。最后，行政核心将为ABC提供支持- DS出版物和辅助研究委员会和ABC-DS生物标本委员会，组织年度NIA 进度报告和每年两次的DSMB报告，并与中央IRB密切合作。

Administrative Core Abstract The Administrative Core will support the overall work of the Alzheimer Biomarker Consortium-Down Syndrome (ABC-DS), which includes eight Clinical Performance sites, seven Cores, three Research Projects and seven research subcontractors. Core staff will organize and coordinate activities and communication across each of these components. This will include providing administrative and budgetary support and monitoring, arranging and organizing meetings, and working closely with the ABC-DS Steering Committee to establish policies and procedures, delineate protocols, monitor recruitment, and track bio-specimen collection, dissemination and storage. In collaboration with the Neuroimaging Core, staff will coordinate all FDA regulatory requirements related to PET radiopharmaceutical production. Finally, the Administrative Core will provide support to the ABC- DS Publications and Ancillary Studies Committee and ABC-DS Bio-specimen Committee, organize annual NIA progress reports and twice-annual DSMB reports, and work closely with the Central IRB.