Human genomics analysis interface for FaceBase 2

FaceBase 2 的人类基因组学分析接口

• 批准号: 9258429
• 负责人: Mary L. Marazita
• 金额: $ 23.1万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9258429
• 关键词: Animal Model; Bioinformatics; Catalogs; Clinical; Communication; Communities; Data; Data Display; Data Set; Data Storage and Retrieval; Development; Enrollment; Ensure; FaceBase; Family; Funding; Gene Expression; Genome; Goals; Human; Image; Imagery; Metadata; Modeling; Mus; National Institute of Dental and Craniofacial Research; Ontology; Phase; Policies; Procedures; Protocols documentation; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resources; Sampling; Secure; Software Tools; Work; Zebrafish; animal data; base; biobank; comparative; craniofacial; data integration; data management; data modeling; experience; genome wide association study; human genomics; improved; meetings; novel; phenome; public health relevance; software development; success; tool; web site

DESCRIPTION (provided by applicant): The first phase of the NIDCR-funded FaceBase Consortium began in 2009 (FaceBase1), with an overall goal to improve understanding of midface development by integrating across diverse data from animal models (mouse and zebrafish) and humans. The current application is part of the second phase of FaceBase (FaceBase2) which has a mandate broadened to the entire craniofacial domain. Our team created and managed the FaceBase1 Hub, and will leverage that effort for the FaceBase2 Data Management and Integration Hub. FaceBase2 will provide a fully-integrated resource to promote translational craniofacial research while providing a model for similar domain-specific resources. The FaceBase2 Hub will build on current FaceBase1 datasets, tools, and approaches, and includes a highly complementary set of investigators and consultants to facilitate integration of the new FaceBase2 spoke projects into FaceBase for the benefit of the entire craniofacial research community. Our experience with the FaceBase1 Hub led to a number of conclusions that have shaped our plans for the new FaceBase2 Hub. It is necessary to actively engage with spoke researchers to develop resource descriptions, integration plans, policies, and procedures. FaceBase2 must expand the quality, quantity, utility, and integration of FaceBase data. We will enhance the website and develop new tools, making FaceBase a model for integrative translational bioinformatics. We will develop and integrate novel software tools fo Hub-based analysis of FaceBase data. FaceBase2 will continue to maintain and build on the success of the FaceBase Biorepository. FaceBase2 will continue to align consortium efforts with community needs: To these ends, this FaceBase2 Hub will have the following concrete goals, to: (1) Develop and Maintain FaceBase Resources; (2) Develop Software Tools; (3) Maintain and Extend FaceBase Biorepository; (4) Coordinate FaceBase 2 Consortium.

描述（由申请人提供）：NIDCR资助的Facebase联盟的第一阶段始于2009年（FaceBase1），其总体目标是通过整合来自动物模型（小鼠和斑马鱼）和人类的各种数据，以提高对中心发展的理解。当前的应用是Facebase第二阶段（FaceBase2）的一部分，该阶段的授权扩大到整个颅面结构域。我们的团队创建并管理FaceBase1中心，并将这项工作用于FaceBase2数据管理和集成中心。 FaceBase2将提供完全集成的资源，以促进翻译颅面研究，同时为类似领域的资源提供模型。 FaceBase2 Hub将在当前的FaceBase1数据集，工具和方法上构建，并包括一组高度互补的研究人员和顾问，以促进将新的FaceBase2 Spoke Projects整合到Facebase中，以使整个颅面研究社区受益。我们在FaceBase1中心的经验导致了许多结论，这些结论塑造了我们对新FaceBase2中心的计划。有必要与讲话研究人员积极互动，以制定资源描述，集成计划，政策和程序。 FaceBase2必须扩大面孔数据的质量，数量，实用性和集成。我们将增强网站并开发新的工具，使面库成为综合翻译生物信息学的模型。我们将开发并整合基于HUB的面部基础数据分析的新型软件工具。 FaceBase2将继续维持和建立Facebase Biorepository的成功。 FaceBase2将继续将财团的工作与社区需求保持一致：为了这些目的，该FaceBase2中心将具有以下具体目标，以：（1）开发和维持面孔资源； （2）开发软件工具； （3）维护和扩展面碱生物座； （4）坐标面库2联盟。