Interpersonal Emotion Regulation in Neurodegenerative Disease: Pathways to Caregiver Health

项目总结 神经退行性疾病会导致严重的认知、情感和功能障碍 让个人依赖提供护理的亲密关系伙伴。尽管照顾孩子是一种积极的 为许多个人提供经验，为因以下原因而有社会情绪缺陷的个人提供护理 神经退行性疾病可能导致配偶照顾者的不良后果，包括精神障碍 和身体健康的结果。然而，很少有研究研究通过 照顾者的社会情绪缺陷会导致照顾者的健康问题。当前的研究 重点关注人际情绪调节-照顾者的负面情绪的程度 在冲突和急性应激时，照顾者的积极情绪会被上调 他们的照顾者--作为将照顾者的社会情绪缺陷与照顾者联系起来的潜在途径 健康问题。这项研究将对神经症患者和阿尔茨海默病患者进行比较。 和行为变异额颞叶痴呆(BvFTD)来了解这些不同的疾病类型是如何 影响人际情绪调节(目标1)。这项研究将描绘出神经、自主和 人际情绪调节的行为相关性(目标2)，重点是疾病相关的萎缩， 理论上认为有助于人际情绪调节的自主神经和行为因素，包括迷走神经 灵活性，对他人情绪表达的视觉关注，以及同理心。最后，这项研究将检验 不良的人际情绪调节是否会纵向影响照顾者的健康(目标3)。为了支持 作为开展拟议研究的候选人，计划在以下方面进行培训：(A)衡量 呼吸性窦性心律不齐作为迷走神经灵活性的指标，(B)固定和移动眼球跟踪技术 获取对情绪刺激的视觉注意；(C)健康心理学和采集血液健康 (D)结构方程建模框架中的统计增长建模技术。这个 加州大学伯克利分校心理学系内的研究环境 加州大学旧金山分校的记忆和衰老中心将是拟议中的培训的理想选择 和研究目标，以及发展候选人的专业技能。培训将在以下条件下进行 指导每个培训领域的知名专家，并将支持候选人的职业目标 过渡到独立的研究生涯。拟议的研究将提供一种更细微的 了解神经退行性疾病引起的社会情绪障碍的框架 随着时间的推移，照顾者的健康状况，并增进我们对人际情绪调节和 促进或阻碍晚年健康的二元过程。

PROJECT SUMMARY Neurodegenerative diseases lead to profound cognitive, emotional, and functional impairments that leave individuals dependent upon close relational partners who provide care. Although caregiving is a positive experience for many individuals, providing care for an individual who has socioemotional deficits due to neurodegenerative disease can lead to adverse consequences for spousal caregivers, including poor mental and physical health outcomes. However, little research examines the dyadic, interpersonal pathways through which care recipients’ socioemotional deficits lead to health problems for their caregivers. The current research focuses on interpersonal emotion regulation – the extent to which a caregiver’s negative emotion is downregulated and a caregiver’s positive emotion is upregulated during conflict and an acute stressor with their care recipient – as a potential pathway linking care recipients’ socioemotional deficits to their caregivers’ health problems. The research will compare neurotypicals with individuals who have Alzheimer’s Disease (AD) and behavioral variant frontotemporal dementia (bvFTD) to understand how these different disease types influence interpersonal emotion regulation (Aim 1). The research will delineate the neural, autonomic, and behavioral correlates of interpersonal emotion regulation (Aim 2), with an emphasis on disease related atrophy, autonomic, and behavioral factors theorized to subserve interpersonal emotion regulation, including vagal flexibility, visual attention to other’s emotional expressions, and empathy. Finally, this research will examine whether poor interpersonal emotion regulation impacts caregiver health longitudinally (Aim 3). To support the candidate in conducting the proposed research, training is planned in: (a) measurement of changes in respiratory sinus arrhythmia as an index of vagal flexibility, (b) stationary and mobile eye-tracking technologies to capture visual attention to emotional stimuli, (c) health psychology and the collection of blood based health biomarkers, and (d) statistical growth modelling techniques in a structural equation modeling framework. The research environments within the Department of Psychology at the University of California, Berkeley, and the Memory and Aging Center at the University of California, San Francisco, will be ideal for the proposed training and research goals, as well as for developing the candidate’s professional skills. Training will occur under the mentorship of renowned experts in each area of training, and will support the candidates career goal of transitioning into an independent research career. The proposed research will provide a more nuanced framework for understanding how socioemotional impairments due to neurodegenerative diseases affect caregivers’ health over time, and advance our understanding of interpersonal emotion regulation and the dyadic processes that promote or hinder health in late life.