Portable Ankle Robotics to Reverse Foot Drop After Stroke.

整体项目总结 该提案最终敲定了便携式脚踝机器人的设计，作为逆转足部下垂和足部下垂的治疗设备 中风后恢复安全的独立行走，然后进行严格的随机临床试验，以建立 这一新的市场应用的临床疗效。产品开发灵感来自我们的五个积极的临床 研究表明，脚踝机器人介导的功能性运动学习在 运动任务型训练的背景。在第一阶段，我们最终确定了一种更轻的电池 提供动力的无线控制脚踝机器人(AMBLE)，满足常规的基本临床可用性标准 注重行动能力的理疗(PT)。第一阶段的具体成果包括设计和台架测试 功能测试版原型，在地面行走过程中满足关键的安全性、稳定性和舒适性指标 完全集成到PT的移动性任务。第二阶段(3年)是一项盲法随机临床试验，研究 假设9周(18个疗程)的PTR比单独进行PT更有效地逆转脚下垂，因为 采用仪表化步态生物力学和临床医生盲法评估。我们的结果将确保安全 作为一种新的市场应用，填补未得到满足的需求，逆转脚下垂的初步疗效，以及轮班护理 向跨其他受损关节的PT集成的机器人外骨骼迈进。

Overall Project Summary This proposal finalizes the design of a portable ankle robot as a therapeutic device to reverse foot drop and restore safe independent walking after stroke, then conducts a rigorous randomized clinical trial to establish clinical efficacy for this new market application. Product development is inspired by our five positive clinical studies that demonstrate that ankle robot-mediated functional motor learning is most effectively conducted in the context of locomotor task-oriented training. In Phase I, we pursued finalization of a lighter weight, battery powered, and wirelessly controlled ankle robot (AMBLE) that meets basic clinical usability standards for regular mobility-focused physical therapy (PT). Specific Phase I accomplishments include designing and bench testing a functional beta prototype that meets key safety, stability, and comfort metrics during over-ground walking and mobility tasks for full integration into PT. Phase II (3-yrs) is a blinded, randomized clinical trial investigating the hypothesis that 9 weeks (18 sessions) of PTR is more effective than PT alone to reverse foot drop as assessed by instrumented gait biomechanics and blinded clinician assessment. Our results will establish safety and initial efficacy for reversal of foot drop as a new market application filling an unmet need, and shift care toward PT-integrated robotic exoskeletons across other impaired joints.