Necroptosis and Human Disease

坏死性凋亡和人类疾病

• 批准号: nhmrc : 1142669
• 负责人: Dr Joanne Hildebrand
• 金额: $ 29.14万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/necroptosis-human-disease/1319752
• 关键词: Necroptosis; Human; Disease

Cell death is a normal process that permits the growth and defense of our vital tissues. One kind of cell death, necroptosis, is characterised by the swelling and bursting of cells, triggering inflammation. Necroptosis is a key feature of illnesses ranging from colitis to arthritis, and contributes to the brain and heart damage that follows strokes and heart attacks. Understanding necroptotic cell death will pave the way for new therapies for those who suffer from these devastating conditions.

细胞死亡是一个正常的过程，允许我们重要组织的生长和防御。一种细胞死亡，坏死性凋亡，其特征是细胞肿胀和破裂，引发炎症。坏死是从结肠炎到关节炎等疾病的一个关键特征，并导致中风和心脏病发作后的大脑和心脏损伤。了解坏死性细胞死亡将为患有这些毁灭性疾病的人提供新疗法铺平道路。