Dissecting BAFF Receptor Signals: Key Mediators of B-Lymphocyte Survival and Autoimmune Disease

解析 BAFF 受体信号：B 淋巴细胞存活和自身免疫性疾病的关键介质

• 批准号: nhmrc : 541951
• 负责人: Dr Joanne Hildebrand
• 金额: $ 25.08万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-baff-receptor-autoimmune-disease/115869
• 关键词: Dissecting; BAFF; Receptor; Signals; Key

B-Cells of the immune system need a growth factor named 'BAFF' to grow and survive. Elevated levels of BAFF have been detected in patients suffering from autoimmune diseases like lupus and arthritis, and B-Cell cancers like myeloma. This study will determine the identity of the chemical messages that BAFF sends to B-Cells, and how these facilitate B-Cell growth and survival. This will provide a framework for the design of targeted drug therapies that reduce the severity of BAFF related diseases.

免疫系统的B细胞需要一种名为“BAFF”的生长因子来生长和生存。在患有自身免疫性疾病如狼疮和关节炎以及B细胞癌症如骨髓瘤的患者中检测到BAFF水平升高。这项研究将确定BAFF发送给B细胞的化学信息的身份，以及这些信息如何促进B细胞的生长和存活。这将为设计降低BAFF相关疾病严重程度的靶向药物治疗提供一个框架。