Administrative Supplement for R01 EY 030565-01A1 - Contextual Fear Conditioning Apparatus

R01 EY 030565-01A1 的行政补充 - 情境恐惧调节装置

• 批准号: 10661426
• 负责人: Tiffany M. Schmidt
• 金额: $ 4.19万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661426
• 关键词: Administrative Supplement; Anatomy; Area; Behavior; Brain; Brain region; Data; Electrophysiology (science); Evaluation; Eye; Glutamates; Lead; Light; Modeling; Neurotransmitters; Organism; Peptides; Photosensitivity; Physiology; Research; Retina; Retinal Ganglion Cells; Role; Sleep; Testing; Visual; base; behavior influence; conditioned fear; gamma-Aminobutyric Acid; melanopsin; mouse genetics; patch clamp

PROJECT SUMMARY for R01 EY 030565-01A1 Light is a profoundly important regulator of physiology and behavior across a wide range of organisms. Light information is relayed from the retina to the brain via glutamate released from retinal ganglion cells (RGCs) at more than 30 brain regions, with some RGCs also co-releasing peptide transmitters. Despite the prevailing dogma that all RGCs release glutamate, there have been hints that some RGCs may be GABAergic. However, the identity and function of these potentially GABAergic RGCs is completely unknown. Our recent findings indicate that a subset of the melanopsin-expressing, intrinsically photosensitive (ip)RGCs are GABAergic. This proposal will test the overarching hypothesis that GABA release from the melanopsin- expressing, intrinsically photosensitive (ip)RGCs influences non-image forming behaviors. The aims of this proposal will define the types and targets of GABAergic RGCs and their role in visual behavior using a combination of mouse genetics, channelrhodopsin-based circuit tracing, anatomy, patch clamp electrophysiology, and behavior. In addition to mapping the identity and function of GABAergic RGCs, these studies will open up new areas of research into the role of inhibitory circuits in light-driven behavior and physiology.

R01 EY 030565-01A1项目总结