Nutrition and Physical Activity Assessment Study

营养和身体活动评估研究

• 批准号: 10655346
• 负责人: JOHANNA W LAMPE
• 金额: $ 71.35万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-12 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10655346
• 关键词: Address; Adherence; American; Amino Acids; Animals; Area; Beverages; Biological Markers; Biomarker of Dietary Intake; Blood; Calibration; Carbohydrates; Carbon; Carbon Isotopes; Cardiovascular Diseases; Carotenoids; Characteristics; Chronic Disease; Collection; Coronary heart disease; Data; Development; Diabetes Mellitus; Diet; Diet Habits; Dietary Assessment; Dietary Component; Dietary Practices; Disease; Disease Outcome; Eating; Energy Intake; Equation; Evaluation; Fatty Acids; Fishes; Food; Food Patterns; Foundations; Funding; Future; Goals; Grant; Health; Health Policy; Healthy Eating; Heart failure; Human; Intake; Investigation; Link; Malignant Neoplasms; Measurement; Measures; Meat; Mediterranean Diet; Methodology; Micronutrients; Monitor; Nitrogen; Nitrogen Isotopes; Non-Insulin-Dependent Diabetes Mellitus; Nutrient; Nutritional; Observational Study; Participant; Patient Self-Report; Pattern; Phospholipids; Physical activity; Play; Population Heterogeneity; Population Intervention; Postmenopause; Potassium; Prevention Research; Productivity; Proteins; Protocols documentation; Public Health; Public Health Applications Research; Reporting; Research; Research Design; Research Priority; Risk; Role; Seafood; Self Correction; Serum; Sodium; Specific qualifier value; Specimen; Statistical Methods; Testing; Urine; Validation; Variant; Woman; Women' s Health; Work; alpha Tocopherol; biomarker development; biomarker identification; cancer risk; candidate marker; cohort; diabetes risk; diet and cancer; dietary; dietary guidelines; disorder risk; doubly-labeled water; epidemiology study; feeding; hazard; high dimensionality; indexing; innovation; meetings; metabolomics; novel; nutrition; nutritional epidemiology; preservation; prevent; saturated fat; small molecule; stable isotope; study population; sugar; tool; urinary

PROJECT SUMMARY This competing renewal of CA119171-12 “Nutrition and Physical Activity Assessment Study” (NPAAS) continues to focus on the development of novel dietary biomarkers and application of these biomarkers to investigations of diet and cancer, cardiovascular disease and type 2 diabetes risk in the Women’s Health Initiative (WHI) cohorts of postmenopausal U.S. women. Our work uses objective biomarkers of nutrients, foods and dietary patterns using blood and urine biospecimens collected in controlled feeding studies where types and quantities of foods and beverages are known. The dietary biomarkers can be used as stand-alone assessments of diet or, as emphasized in this proposal, they may be able to be extended to make them suitable for inexpensive disease association applications using a regression calibration approach. Progress has been made on the identification of objective measures of some dietary variables for public health applications, but there is still limited use of high-dimensional platforms (e.g., metabolomics in blood and urine) for this purpose. Further development is also needed for discovery and evaluation of stable isotope biomarkers of important dietary components, such as meat, fish and added sugars, where there are likely links to chronic disease risk. The discovery and validation of objective measures of healthy dietary patterns is another gap that we will address. In this cycle of funding, we propose to contribute to these research areas and to carry out generalizability studies toward extending these biomarker-intake results to diverse populations beyond the WHI. Our specific aims are: 1) To develop further and evaluate candidate biomarkers of foods, nutrients and other dietary compounds informed by data from the NPAAS feeding study (n=153) and to apply biomarkers meeting our prespecified NPAAS-derived criteria to examine associations with risk of cancer, cardiovascular disease and type 2 diabetes in WHI cohorts of postmenopausal women (n=161,808); 2) To measure serum carbon and nitrogen isotope ratios and amino acid carbon isotope ratios as biomarkers of fish/seafood, animal protein and added sugars in the NPAAS Observational Study (n=450) and to apply these measures to test associations with risk of cancer, cardiovascular disease and diabetes in WHI cohorts; 3) To identify and evaluate candidate dietary biomarkers of healthy eating patterns (e.g., Healthy Eating Index, Alternative Mediterranean Diet Score) for testing associations between these eating patterns with the same set of chronic diseases in WHI cohorts; and 4) To test, using blood and urine metabolomics, the generalizability of novel metabolomic biomarkers identified in the NPAAS feeding study to diverse study populations in two controlled feeding studies. Our productive research team is expected to make additional, innovative contributions to nutritional epidemiology research and more broadly to chronic disease prevention research. Our research builds on the understanding that biomarkers of dietary intake, as stand-alone exposures or as tools to calibrate self-report, are crucial to the development of reliable information on the effects of diet on chronic disease risk.

项目总结

项目成果

Health risks and benefits from calcium and vitamin D supplementation: Women's Health Initiative clinical trial and cohort study.

• DOI: 10.1007/s00198-012-2224-2
• 发表时间: 2013-02
• 期刊: OSTEOPOROSIS INTERNATIONAL
• 影响因子: 4
• 作者: Prentice, R. L.;Pettinger, M. B.;Jackson, R. D.;Wactawski-Wende, J.;LaCroix, A. Z.;Anderson, G. L.;Chlebowski, R. T.;Manson, J. E.;Van Horn, L.;Vitolins, M. Z.;Datta, M.;LeBlanc, E. S.;Cauley, J. A.;Rossouw, J. E.
• 通讯作者: Rossouw, J. E.

Calibration of self-reported dietary measures using biomarkers: an approach to enhancing nutritional epidemiology reliability.

• DOI: 10.1007/s11883-013-0353-5
• 发表时间: 2013-09
• 期刊: CURRENT ATHEROSCLEROSIS REPORTS
• 影响因子: 5.8
• 作者: Prentice, Ross L.;Tinker, Lesley F.;Huang, Ying;Neuhouser, Marian L.
• 通讯作者: Neuhouser, Marian L.

Daily energy expenditure through the human life course.

通过人类生活课程的每日能量消耗。

• DOI: 10.1126/science.abe5017
• 发表时间: 2021-08-13
• 期刊: Science (New York, N.Y.)
• 作者: Pontzer H;Yamada Y;Sagayama H;Ainslie PN;Andersen LF;Anderson LJ;Arab L;Baddou I;Bedu-Addo K;Blaak EE;Blanc S;Bonomi AG;Bouten CVC;Bovet P;Buchowski MS;Butte NF;Camps SG;Close GL;Cooper JA;Cooper R;Das SK;Dugas LR;Ekelund U;Entringer S;Forrester T;Fudge BW;Goris AH;Gurven M;Hambly C;El Hamdouchi A;Hoos MB;Hu S;Joonas N;Joosen AM;Katzmarzyk P;Kempen KP;Kimura M;Kraus WE;Kushner RF;Lambert EV;Leonard WR;Lessan N;Martin C;Medin AC;Meijer EP;Morehen JC;Morton JP;Neuhouser ML;Nicklas TA;Ojiambo RM;Pietiläinen KH;Pitsiladis YP;Plange-Rhule J;Plasqui G;Prentice RL;Rabinovich RA;Racette SB;Raichlen DA;Ravussin E;Reynolds RM;Roberts SB;Schuit AJ;Sjödin AM;Stice E;Urlacher SS;Valenti G;Van Etten LM;Van Mil EA;Wells JCK;Wilson G;Wood BM;Yanovski J;Yoshida T;Zhang X;Murphy-Alford AJ;Loechl C;Luke AH;Rood J;Schoeller DA;Westerterp KR;Wong WW;Speakman JR;IAEA DLW Database Consortium
• 通讯作者: IAEA DLW Database Consortium

Factors relating to eating style, social desirability, body image and eating meals at home increase the precision of calibration equations correcting self-report measures of diet using recovery biomarkers: findings from the Women's Health Initiative.

• DOI: 10.1186/1475-2891-12-63
• 发表时间: 2013-05-16
• 期刊: Nutrition journal
• 影响因子: 5.4
• 作者: Mossavar-Rahmani Y;Tinker LF;Huang Y;Neuhouser ML;McCann SE;Seguin RA;Vitolins MZ;Curb JD;Prentice RL
• 通讯作者: Prentice RL

Associations of Biomarker-Calibrated Intake of Total Sugars With the Risk of Type 2 Diabetes and Cardiovascular Disease in the Women's Health Initiative Observational Study.

女性健康倡议观察性研究中生物标志物校准的总糖摄入量与 2 型糖尿病和心血管疾病风险的关联。

• DOI: 10.1093/aje/kwy115
• 发表时间: 2018
• 期刊: American journal of epidemiology
• 影响因子: 5
• 作者: Tasevska,Natasha;Pettinger,Mary;Kipnis,Victor;Midthune,Douglas;Tinker,LesleyF;Potischman,Nancy;Neuhouser,MarianL;Beasley,JeannetteM;VanHorn,Linda;Howard,BarbaraV;Liu,Simin;Manson,JoAnnE;Shikany,JamesM;Thomson,CynthiaA;P
• 通讯作者: P