Molecular and Cellular Mechanisms of Wound Repair

伤口修复的分子和细胞机制

基本信息

  • 批准号:
    10657172
  • 负责人:
  • 金额:
    $ 46.56万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-05-01 至 2027-07-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT Most cells of the body experience physiological and environmental stresses during their normal daily functions that can lead to a ruptured cell cortex (plasma membrane and underlying cortical cytoskeleton). The capacity of cells to rapidly repair general daily injuries, as well as ones resulting from trauma, infection, or diseases/cancer, is essential for their survival. The general aim of this proposal is to delineate how cells deal with such cell cortex disruptions to efficiently and effectively repair the lesions. We have developed a robust inducible single cell repair model using the syncytial Drosophila embryo that has superb amenability for live imaging and genetic tractability that is unavailable in other cell wound repair models. Our repair model has allowed us to successfully employ global genetic approaches for the first time to delineate the outline of cellular events and to identify many required genes/gene families providing clear molecular entry points for investigating specific key steps in the repair process. Our long-term goal is to establish the molecular framework underpinning cell wound repair. The specific aims of this proposal are 1) to determine the means by which the membrane plug re-seals the torn plasma membrane then facilitates wound closure; 2) to determine how the actin ring is attached to the overlying plasma membrane to coordinate their actions as the wound is pulled closed; and 3) to elucidate the basis of cell cortex remodeling following wound closure. Our findings will impact our understanding of cell wound repair across phyla, complement work done in other cell repair models, provide new insights into key players/events needed for efficient repair, as well as how they work in concert to achieve successful wound closure, and contribute to our understanding of related fundamental cellular and developmental events. Our studies are also expected to be of significant medical relevance, as understanding the molecules, machineries, and pathways governing cell wound repair will be extremely valuable for developing new or enhancing existing strategies for treating cellular damage, and for disciplines such as regenerative medicine where cell based constructs are used to reconstruct tissues or clinical drug delivery systems where molecules cross cell membranes.
项目总结/文摘

项目成果

期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair.
  • DOI:
    10.1083/jcb.201704145
  • 发表时间:
    2017-12-04
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Nakamura M;Verboon JM;Parkhurst SM
  • 通讯作者:
    Parkhurst SM
Rho family GTPase functions in Drosophila epithelial wound repair.
  • DOI:
    10.4161/21541248.2014.982415
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Verboon JM;Parkhurst SM
  • 通讯作者:
    Parkhurst SM
Rho family GTPases bring a familiar ring to cell wound repair.
  • DOI:
    10.4161/21541248.2014.992262
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Verboon JM;Parkhurst SM
  • 通讯作者:
    Parkhurst SM
Into the breach: how cells cope with wounds.
深入突破口:细胞如何应对伤口。
  • DOI:
    10.1098/rsob.180135
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    5.8
  • 作者:
    Nakamura,Mitsutoshi;Dominguez,AndrewNM;Decker,JacobR;Hull,AlexanderJ;Verboon,JeffreyM;Parkhurst,SusanM
  • 通讯作者:
    Parkhurst,SusanM
Coordination of Rho family GTPase activities to orchestrate cytoskeleton responses during cell wound repair.
  • DOI:
    10.1016/j.cub.2013.11.048
  • 发表时间:
    2014-01-20
  • 期刊:
  • 影响因子:
    9.2
  • 作者:
    Abreu-Blanco, Maria Teresa;Verboon, Jeffrey M.;Parkhurst, Susan M.
  • 通讯作者:
    Parkhurst, Susan M.
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SUSAN M PARKHURST其他文献

SUSAN M PARKHURST的其他文献

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{{ truncateString('SUSAN M PARKHURST', 18)}}的其他基金

Cellular mechanisms of nucleocytoplasmic export through Nuclear Envelope Budding
通过核膜出芽的核细胞质输出的细胞机制
  • 批准号:
    10541746
  • 财政年份:
    2021
  • 资助金额:
    $ 46.56万
  • 项目类别:
Cellular mechanisms of nucleocytoplasmic export through Nuclear Envelope Budding
通过核膜出芽的核细胞质输出的细胞机制
  • 批准号:
    10642008
  • 财政年份:
    2021
  • 资助金额:
    $ 46.56万
  • 项目类别:
Cellular mechanisms of nucleocytoplasmic export through Nuclear Envelope Budding
通过核膜出芽的核细胞质输出的细胞机制
  • 批准号:
    10655419
  • 财政年份:
    2021
  • 资助金额:
    $ 46.56万
  • 项目类别:
Cellular mechanisms of nucleocytoplasmic export through Nuclear Envelope Budding
通过核膜出芽的核细胞质输出的细胞机制
  • 批准号:
    10271664
  • 财政年份:
    2021
  • 资助金额:
    $ 46.56万
  • 项目类别:
Cellular mechanisms of nucleocytoplasmic export through Nuclear Envelope Budding
通过核膜出芽的核细胞质输出的细胞机制
  • 批准号:
    10461057
  • 财政年份:
    2021
  • 资助金额:
    $ 46.56万
  • 项目类别:
Mechanoregulation of Cell Functions during Embryogenesis
胚胎发生过程中细胞功能的机械调节
  • 批准号:
    9567333
  • 财政年份:
    2018
  • 资助金额:
    $ 46.56万
  • 项目类别:
Mechanoregulation of Cell Functions during Embryogenesis
胚胎发生过程中细胞功能的机械调节
  • 批准号:
    10170395
  • 财政年份:
    2018
  • 资助金额:
    $ 46.56万
  • 项目类别:
Mechanoregulation of Cell Functions during Embryogenesis
胚胎发生过程中细胞功能的机械调节
  • 批准号:
    10407016
  • 财政年份:
    2018
  • 资助金额:
    $ 46.56万
  • 项目类别:
Mechanoregulation of Cell Functions during Embryogenesis
胚胎发生过程中细胞功能的机械调节
  • 批准号:
    10638437
  • 财政年份:
    2018
  • 资助金额:
    $ 46.56万
  • 项目类别:
Molecular and Cellular Mechanisms of Wound Repair
伤口修复的分子和细胞机制
  • 批准号:
    9982330
  • 财政年份:
    2015
  • 资助金额:
    $ 46.56万
  • 项目类别:

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由两类细菌肌动蛋白 MreB 驱动的新型运动系统
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研究肌动蛋白和微管如何协调及其相关性。
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