Trauma and Cardiometabolic Health in an American Indian Community

项目总结 美国印第安人(AIS)的预期寿命比所有印第安人少5.5岁 美国的其他比赛。在认可机构和服务机构中，心血管疾病的患病率一直在上升。 作为人工授精患者死亡的主要原因。创伤会增加心血管健康状况不佳的风险。 与其他种族和种族相比，人工智能的儿童创伤发生率高得不成比例 种族群体。此外，人工智能还处理历史创伤带来的持续影响， 这是与失去土地、语言、 和文化传统。童年和历史上的创伤仍然有可能 助长了持续的人工智能健康差距。青少年心理创伤与健康的关系 其他种族和民族群体已经被研究了很多年，研究表明 对急性应激的生理反应的差异可能是导致 对健康造成的创伤。到目前为止，创伤与高血压的风险标记物之间的关系 心脏代谢性疾病和不良的心理健康，以及生理反应对 这种关系中的压力，还没有在专门的人工智能社区中进行研究。 为了解决这一关键的研究差距，本研究将阐明两者之间的关系 蒙大拿州黑脚社区的创伤和健康之间的关系。的预期寿命 黑脚族成员比活着的非西班牙裔白人的预期寿命少13岁 在同一县，部分原因是心脏代谢不成比例的高发病率 社区的疾病和精神健康状况，这两种疾病的高发病率都 精神创伤。 居住在同一地区的人工智能成年人样本(N=400，50%女性，年龄范围：18-25岁) 预订部将参与一项横断面研究。参与者将报告童年和 历史创伤，酒精使用，抑郁和焦虑症状，将完成两个 面对面的拜访。在第一次访问期间，参与者将接受静息血压评估， 测量腰围，并采集血液样本作为心脏代谢风险的生物标记物。 在访问2期间，参与者将测量动脉僵硬并完成验证的急性 心理实验室范式。参与者将有心血管、神经内分泌和 测量对急性应激的炎症反应。这些发现最终将通知未来 干预努力，并为纵向工作提供基础，以捕获 在过去和正在进行的创伤背景下的心脏代谢和心理健康。

PROJECT SUMMARY American Indians (AIs) have a lower life expectancy by 5.5 years less compared to all other U.S. races. Cardiovascular disease prevalence has been increasing among AIs and serves as the leading cause of mortality among AIs. Trauma confers risk for poor cardiovascular health. AIs have disproportionately higher incidence of childhood trauma compared to other racial and ethnic groups. Additionally, AIs deal with the ongoing implications from historical trauma, which is the emotional and psychological wounding associated with the loss of land, language, and cultural traditions. It remains possible that both childhood and historical traumas may contribute to persisting AI health disparities. The relationship between trauma and health in other racial and ethnic groups has been studied for many years, and research indicates differences in physiological responses to acute stress may contribute to the negative effects of trauma on health. To date, the relationship between trauma and markers of risk for cardiometabolic disease and poor mental health, and the role of physiological responses to stress in this relationship, have not been studied in an exclusively AI community. To address this critical research gap, the present study will elucidate relationships between trauma and health in the Blackfeet community in Montana. The life expectancy for members of the Blackfeet is 13 years less than the life expectancy of non-Hispanic Whites living in the same county, in part due to the disproportionality high incidence of cardiometabolic disease and mental health conditions in the community which suffers from both high rates of trauma. A sample of AI adults (N=400, 50% female, age range: 18-25 years) residing on the same reservation will participate in a cross-sectional study. Participants will report childhood and historical trauma, alcohol use, and depressive and anxiety symptomology and will complete two in-person visits. During Visit 1, participants will have their resting blood pressure assessed, waist circumference measured, and blood samples taken for biomarkers of cardiometabolic risk. During Visit 2, participants will have arterial stiffness measured and complete a validated acute psychological laboratory paradigm. Participants will have cardiovascular, neuroendocrine, and inflammatory responses to the acute stress measured. The findings will ultimately inform future intervention efforts and provide the basis for longitudinal work to capture trajectories of cardiometabolic and mental health in the context of past and ongoing trauma.