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Trauma and Cardiometabolic Health in an American Indian Community

美洲印第安人社区的创伤和心脏代谢健康

基本信息

批准号：
10657249
负责人：
Annie T Ginty
金额：
$ 73.52万
依托单位：
MONTANA STATE UNIVERSITY - BOZEMAN
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-15 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10657249
关键词：
Accounting Acute Address Adult Age Alcohol consumption American Indians Anxiety Behavior assessment Biological Biological Markers Blackfeet Blood Pressure Blood specimen Buffers Cardiometabolic Disease Cardiovascular Diseases Cardiovascular system Childhood Collaborations Communities County Cross-Sectional Studies Data Emotional Ensure Equation Ethnic Population Exposure to Female Future Generations Glucose Goals Health Health behavior Immune system Incidence Individual Differences Inflammation Inflammatory Inflammatory Response Intervention Knowledge Laboratories Language Life Expectancy Link Longevity Longitudinal cohort Measures Mental Health Methods Modeling Montana Neurosecretory Systems Not Hispanic or Latino Obesity Outcome Participant Pathway interactions Persons Physiological Premature Mortality Prevalence Protocols documentation Psychological Stress Race Reaction Reporting Research Reservations Rest Risk Risk Factors Risk Marker Role Sampling Standardization Stress System Testing Training Trauma Visit Work acute stress alcohol measurement arterial stiffness biological sex cardiometabolic risk cardiometabolism cardiovascular health community based participatory research depressive symptoms design disorder risk experience health disparity health disparity populations member mortality pediatric trauma physical conditioning psychologic racial population research study resilience factor response social stressor substance use transmission process waist circumference wound young adult

项目摘要

PROJECT SUMMARY American Indians (AIs) have a lower life expectancy by 5.5 years less compared to all other U.S. races. Cardiovascular disease prevalence has been increasing among AIs and serves as the leading cause of mortality among AIs. Trauma confers risk for poor cardiovascular health. AIs have disproportionately higher incidence of childhood trauma compared to other racial and ethnic groups. Additionally, AIs deal with the ongoing implications from historical trauma, which is the emotional and psychological wounding associated with the loss of land, language, and cultural traditions. It remains possible that both childhood and historical traumas may contribute to persisting AI health disparities. The relationship between trauma and health in other racial and ethnic groups has been studied for many years, and research indicates differences in physiological responses to acute stress may contribute to the negative effects of trauma on health. To date, the relationship between trauma and markers of risk for cardiometabolic disease and poor mental health, and the role of physiological responses to stress in this relationship, have not been studied in an exclusively AI community. To address this critical research gap, the present study will elucidate relationships between trauma and health in the Blackfeet community in Montana. The life expectancy for members of the Blackfeet is 13 years less than the life expectancy of non-Hispanic Whites living in the same county, in part due to the disproportionality high incidence of cardiometabolic disease and mental health conditions in the community which suffers from both high rates of trauma. A sample of AI adults (N=400, 50% female, age range: 18-25 years) residing on the same reservation will participate in a cross-sectional study. Participants will report childhood and historical trauma, alcohol use, and depressive and anxiety symptomology and will complete two in-person visits. During Visit 1, participants will have their resting blood pressure assessed, waist circumference measured, and blood samples taken for biomarkers of cardiometabolic risk. During Visit 2, participants will have arterial stiffness measured and complete a validated acute psychological laboratory paradigm. Participants will have cardiovascular, neuroendocrine, and inflammatory responses to the acute stress measured. The findings will ultimately inform future intervention efforts and provide the basis for longitudinal work to capture trajectories of cardiometabolic and mental health in the context of past and ongoing trauma.

项目总结