Predoctoral Training in Pharmacological Sciences (Resubmission)

药理学博士前培训（重新提交）

• 批准号: 10657492
• 负责人: Tija C. Jacob
• 金额: $ 31.83万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10657492
• 关键词: Science; Training; pharmacologic; pre-doctoral

Project Summary/Abstract This Predoctoral Training Program is designed to provide a broad education in the Pharmacological Sciences leading to the Ph.D. degree. The Pharmacological Sciences Training Program (PSTP) is centered in the Department of Pharmacology and Chemical Biology at the University of Pittsburgh School of Medicine and is closely associated with the Molecular Pharmacology Graduate Program (MPGP a.k.a. MPTP), and includes faculty from three schools within the University and ten departments including Anesthesiology, Chemistry, Immunology, Medicine, Microbiology and Molecular Genetics, Neurobiology, Neurology, Otolaryngology, Pharmaceutical Sciences, and Structural Biology. Graduate students entering this program are typically first recruited into the Interdisciplinary Biomedical Sciences Graduate Program where they join a program that includes core didactic education in biomedical sciences, scientific ethics and statistics and research rotations. The training program provides graduate coursework in the essential elements of modern pharmacology including neuropharmacology, cancer pharmacology, cardiovascular pharmacology, signal transduction and drug discovery and also elements of quantitative pharmacokinetics, pharmacodynamics and drug metabolism. With the close guidance of the director and vice-director, students are encouraged to work with a select faculty who are dedicated to providing the very best environments to conduct rigorous research of the highest integrity. A culture of inclusivity and support for myriad career tracks is a requirement for trainee laboratories and a mentor training program in these areas is now required as is a course in career exploration that also provides individualized coaching. Students choose mentors from one of six research areas: Cancer Pharmacology, Cell and Organ System Pharmacology, Drug Discovery, Neuropharmacology, Signal Transduction and Structural Pharmacology. Following completion of the comprehensive exam and a dissertation proposal, students are engaged full time in research that promotes critical thinking, collaboration, co-mentorship and core training in experimental design. The PSTP thus provides a contemporary and exciting training opportunity for motivated students within a rigorous and nurturing environment and aims to generate Ph.D. graduates of the highest level of technical and theoretical preparedness.

项目总结/文摘

项目成果

The Yin and Yang of GABAergic and Glutamatergic Synaptic Plasticity: Opposites in Balance by Crosstalking Mechanisms.

GABA 能和谷氨酸能突触可塑性的阴阳：串扰机制的平衡对立。

• DOI: 10.3389/fnsyn.2022.911020
• 发表时间: 2022
• 期刊: FRONTIERS IN SYNAPTIC NEUROSCIENCE
• 影响因子: 3.7
• 作者: Chapman, Caitlyn A.;Nuwer, Jessica L.;Jacob, Tija C.
• 通讯作者: Jacob, Tija C.

Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain.

• DOI: 10.1016/j.nbd.2023.106248
• 发表时间: 2023-09
• 期刊: NEUROBIOLOGY OF DISEASE
• 影响因子: 6.1
• 作者: Lorenz-Guertin, Joshua M.;Povysheva, Nadya;Chapman, Caitlyn A.;Macdonald, Matthew L.;Fazzari, Marco;Nigam, Aparna;Nuwer, Jessica L.;Das, Sabyasachi;Brady, Megan L.;Vajn, Katarina;Bambino, Matthew J.;Weintraub, Susan T.;Johnson, Jon W.;Jacob, Tija C.
• 通讯作者: Jacob, Tija C.

Not making the cut: Techniques to prevent RNA cleavage in structural studies of RNase-RNA complexes.

• DOI: 10.1016/j.yjsbx.2022.100066
• 发表时间: 2022
• 期刊: Journal of structural biology: X
• 作者: Jones SP;Goossen C;Lewis SD;Delaney AM;Gleghorn ML
• 通讯作者: Gleghorn ML

Murine model of triosephosphate isomerase deficiency with anemia and severe neuromuscular dysfunction.

• DOI: 10.1016/j.crneur.2022.100062
• 发表时间: 2022
• 期刊: Current research in neurobiology
• 作者: Myers, Tracey D;Ferguson, Carolyn;Gliniak, Eric;Homanics, Gregg E;Palladino, Michael J
• 通讯作者: Palladino, Michael J

Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma.

• DOI: 10.1038/s41598-021-96471-9
• 发表时间: 2021-09-07
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Manni ML;Heinrich VA;Buchan GJ;O'Brien JP;Uvalle C;Cechova V;Koudelka A;Ukani D;Rawas-Qalaji M;Oury TD;Hart R;Ellgass M;Mullett SJ;Fajt ML;Wenzel SE;Holguin F;Freeman BA;Wendell SG
• 通讯作者: Wendell SG