Neogenin regulates progenitor division and interneuron migration in the developing forebrain

Neogenin 调节前脑发育中的祖细胞分裂和中间神经元迁移

• 批准号: nhmrc : 569638
• 负责人: A/Pr Helen Cooper
• 金额: $ 35.13万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neogenin-regulates-progenitor-developing-forebrain/97498
• 关键词: Neogenin; regulates; progenitor; division; interneuron

In humans, mutations in genes controlling the production of new neurons in the embryonic brain result in severe disruption of the adult cortex. This project tests the hypothesis that one cell surface molecule, Neogenin, regulates the birth of new neurons and their subsequent travels through the developing brain to form the neocortex. The outcome of these studies will provide fundamental insights into the aberrant processes that underlie human mental retardation, epilepsy, dyslexia and autism.

在人类中，控制胚胎大脑中新神经元产生的基因突变会导致成年大脑皮层的严重破坏。这个项目测试了一种假设，即细胞表面的一种分子，Neogenin，调节新神经元的诞生，以及它们随后在发育中的大脑中形成新皮层。这些研究的结果将为人类智力迟钝、癫痫、阅读障碍和自闭症背后的异常过程提供基本的见解。