Neogenin: a molecular determinant of neural progenitor polarity and function

Neogenin：神经祖细胞极性和功能的分子决定因素

• 批准号: nhmrc : 1024201
• 负责人: A/Pr Helen Cooper
• 金额: $ 37.96万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neogenin-molecular-determinant-polarity-function/110324
• 关键词: Neogenin; molecular; determinant; neural; progenitor

The neuroepithelium (NEP) contains the embryonic neural stem cells essential for the production of all neurons in the adult brain. Failure in NEP function leads to devastating neural tube defects and syndromes such as epilepsy, schizophrenia, and mental retardation. This project will identify the molecular mechanisms regulating NEP stem cell activity and the birth of new neurons in the embryonic neocortex.

神经上皮(NEP)含有胚胎神经干细胞，对成人大脑中所有神经元的产生都是必不可少的。NEP功能的丧失会导致毁灭性的神经管缺陷和综合征，如癫痫、精神分裂症和智力低下。该项目将确定调控NEP干细胞活性和胚胎新皮质中新神经元诞生的分子机制。