Neogenin: a regulator of neuronal differentiation and migration in the adult brain

Neogenin：成人大脑中神经元分化和迁移的调节剂

• 批准号: nhmrc : 1010723
• 负责人: A/Pr Helen Cooper
• 金额: $ 22.27万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neogenin-regulator-neuronal-adult-brain/109519
• 关键词: Neogenin; regulator; neuronal; differentiation; migration

Conditions such as Alzheimer�s and Huntington�s diseases, as well as stroke, represent a major burden of disease in Australia. One goal of modern neurobiology is to harness the brain's ability to make new neurons so that we can replace those damaged by disease or injury. We will investigate how an important developmental molecule, Neogenin, promotes the production of new neurons in the adult brain. A second goal is to show that Neogenin can be activated to promote the repair of the damaged brain.

阿尔茨海默病和亨廷顿病以及中风等疾病是澳大利亚的主要疾病负担。现代神经生物学的一个目标是利用大脑制造新神经元的能力，以便我们可以替换那些因疾病或损伤而受损的神经元。我们将研究一种重要的发育分子再生素如何促进成人大脑中新神经元的产生。第二个目标是证明再生蛋白可以被激活以促进受损大脑的修复。