Dissecting the role of RYK in cortical neuron specification and schizophrenia

剖析 RYK 在皮质神经元规范和精神分裂症中的作用

• 批准号: nhmrc : 1061512
• 负责人: A/Pr Helen Cooper
• 金额: $ 69.28万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-role-ryk-specification-schizophrenia/454904
• 关键词: Dissecting; role; RYK; cortical; neuron

Correct production of neuronal subtypes within the neocortex is essential for coordinated brain activity and higher-order functions. Understanding how newborn neurons decide which subtype to adopt is critical as incorrect neuron identity has profound consequences for neocortical function and is associated with schizophrenia and mental disability. We have recently linked one molecule, RYK, to schizophrenia. In this project we will explore how Ryk influences cortical neuron fate.

新皮质内神经元亚型的正确产生对于协调大脑活动和高阶功能至关重要。了解新生神经元如何决定采用哪种亚型至关重要，因为不正确的神经元身份会对新皮质功能产生深远的影响，并与精神分裂症和精神障碍有关。我们最近将一种分子 RYK 与精神分裂症联系起来。在这个项目中，我们将探索 Ryk 如何影响皮质神经元的命运。