Dissecting the role of RYK in cortical neuron specification and schizophrenia

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Correct production of neuronal subtypes within the neocortex is essential for coordinated brain activity and higher-order functions. Understanding how newborn neurons decide which subtype to adopt is critical as incorrect neuron identity has profound consequences for neocortical function and is associated with schizophrenia and mental disability. We have recently linked one molecule, RYK, to schizophrenia. In this project we will explore how Ryk influences cortical neuron fate.