Vermont Genetics Network - Vermont INBRE

佛蒙特州遗传学网络 - 佛蒙特州 INBRE

• 批准号: 10657461
• 负责人: CHRISTOPHER S FRANCKLYN
• 金额: $ 382.03万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10657461
• 关键词: Advisory Committees; Applied Research; Award; Basic Science; Behavior; Bioinformatics; Biomedical Research; Career Choice; Categories; Centers of Research Excellence; Collaborations; Communication; Core Facility; Data Analyses; Development; Education; Educational Curriculum; Enrollment; Evaluation; Extramural Activities; Faculty; First Generation College Students; Fostering; Funding; Genetic; Goals; Grant; Grant Review; Health; Healthcare; Human; Human Resources; Institution; Internships; Leadership; Mentors; Mission; Network Infrastructure; Population; Process; Productivity; Program Research Project Grants; Proteomics; Protocols documentation; Publications; Publishing; Research; Research Infrastructure; Research Training; Resource Sharing; Resources; Rural; STEM field; Services; Students; Universities; Vermont; Woman; Work; career; college; community college; course module; cyber infrastructure; data management; experience; faculty research; innovation; meetings; member; organizational structure; outreach; programs; science education; student training; success; symposium; tool; undergraduate education; undergraduate research; undergraduate research experience; undergraduate student

Project Summary The Mission of the Vermont Genetics Network (VGN) is to build the biomedical research infrastructure in Vermont. Our focus is on human health and behavior as broadly defined. The goal is to build and sustain a culture of research throughout the State of Vermont by facilitating the research capacity of faculty members and the education of undergraduates at our baccalaureate partner institutions. We have created state-of-the-art facilities at the University of Vermont (UVM), the lead institution, to serve the network; promoted faculty and student research at VGN Baccalaureate Partner Institutions (BPIs) with research awards and mentoring; and provided BPIs and other colleges with internship experiences and class modules for students to have hands-on experience with research protocols and use VGN’s facilities. Assessments show that VGN-funded faculty at BPIs and UVM are publishing and becoming competitive. Our efforts in the first 3 ½ years of INBRE 3 have resulted in 114 publications (BPI faculty = 31; Bioinformatics = 21; Proteomics = 50; Microarray = 12), 67 extramural grants (past and current BPI faculty funded in INBRE 3 = 21; Bioinformatics = 8; Proteomics = 38) funded to VGN faculty or facilitated by VGN, and 146 students serving as interns in the STEM fields with 89% of those tracked working in or pursuing graduate work in a STEM field. Our efforts promote a culture of research and provide the facilities to promote faculty research and student training. Four new specific aims in INBRE 4 build upon successes and bring innovation to VGN: 1. Enhance advising of faculty to facilitate grants and articles funded/accepted for publications; 2. Build interdisciplinary thematic groups of faculty scholars to encourage collaboration and enhance the quality of research inquiries; 3. Enhance educational experiences and continue diversification of undergraduates; and 4. Continue to enhance sharing of research resources through our Bioinformatics Core, Proteomics Core, Core Marketplace, and collaboration with other INBREs and UVM COBREs. The Professional Development and Education Core will implement Aims 1, 2, and 3. The Bioinformatics Core will implement Aim 4 (as well as Aims 1 and 3) by providing critical data analysis support for the VGN facilities; giving assistance to network faculty for research and incorporation of research into classes; and supporting cyber infrastructure for network communication and data management. The Proteomics Facility will implement Aim 4 (as well as Aims 1 and 3) by conducting proteomic analyses (our Facility is the only full service one in Vermont, facilitating publication of findings, and providing educational opportunities for students. The Administrative Core will provide logistical, financial, compliance oversight, and external evaluation to ensure that VGN is sensitive to changing needs and evolving strengths of the network institutions. The Administrative Core arranges mentoring and undergraduate intern programs to increase the biomedical workforce size and diversity through the PDE Core. Our focus on Human Health and Behavior allows for greater participation at BPIs than our earlier focus on genetics. VGN has strong support and commitments from all network institutions and collaborations among regional INBREs and COBREs.

项目概要 佛蒙特州遗传学网络 (VGN) 的使命是在佛蒙特州建立生物医学研究基础设施。 我们的重点是广义上的人类健康和行为。目标是建立和维持研究文化 通过促进教职员工的研究能力和教育，在整个佛蒙特州 我们的学士学位合作机构的本科生。 我们在领先机构佛蒙特大学 (UVM) 创建了最先进的设施，为 网络;通过研究奖项促进 VGN 学士学位合作机构 (BPI) 的教师和学生研究 和指导；并为BPI和其他学院提供实习经验和课程模块，供学生学习 研究方案和使用 VGN 设施的实践经验。评估显示，VGN 资助的教师 BPI 和 UVM 正在发布并变得具有竞争力。我们在 INBRE 3 的前 3.5 年中所做的努力取得了以下成果： 114 篇出版物（BPI 教员 = 31；生物信息学 = 21；蛋白质组学 = 50；微阵列 = 12），67 项校外资助（过去 现有 BPI 教师在 INBRE 3 = 21 中获得资助；生物信息学=8；蛋白质组学 = 38) 由 VGN 教员资助或协助 由 VGN 提供，146 名学生在 STEM 领域担任实习生，其中 89% 的学生从事或追求 毕业生在 STEM 领域工作。我们的努力促进研究文化并提供促进教师发展的设施 研究和学生培训。 INBRE 4 的四个新具体目标以成功为基础，为 VGN 带来创新： 1. 加强对教师的建议 促进资助/接受出版物的赠款和文章； 2. 建立跨学科教师专题小组 鼓励学者合作并提高研究探究的质量； 3. 增强教育体验 并继续本科生多元化； 4. 继续通过我们的研究资源加强共享 生物信息学核心、蛋白质组学核心、核心市场以及与其他 INBRE 和 UVM COBRE 的合作。这 专业发展和教育核心将实施目标 1、2 和 3。生物信息学核心将实施 目标 4（以及目标 1 和 3），为 VGN 设施提供关键数据分析支持；给予协助 用于研究和将研究纳入课堂的网络教师；以及支持网络的网络基础设施 通信和数据管理。蛋白质组学设施将通过以下方式实施目标 4（以及目标 1 和 3）： 进行蛋白质组分析（我们的设施是佛蒙特州唯一提供全方位服务的设施，促进研究结果的发表， 并为学生提供教育机会。行政核心将提供后勤、财务、 合规监督和外部评估，以确保 VGN 对不断变化的需求和不断发展的优势保持敏感 的网络机构。行政核心安排指导和本科生实习计划 通过 PDE 核心增加生物医学劳动力规模和多样性。我们关注人类健康和行为 与我们之前对遗传学的关注相比，BPI 允许更多人参与。 VGN 拥有强有力的支持和承诺 来自所有网络机构以及区域 INBRE 和 COBRE 之间的合作。

项目成果

Assessing risk of vector transmission of Chagas disease through blood source analysis using LC-MS/MS for hemoglobin sequence identification.

• DOI: 10.1371/journal.pone.0262552
• 发表时间: 2022
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Penados D;Pineda JP;Laparra-Ruiz E;Galván MF;Schmoker AM;Ballif BA;Monroy MC;Stevens L
• 通讯作者: Stevens L

Not a Simple Tether: Binding of Toxoplasma gondii AMA1 to RON2 during Invasion Protects AMA1 from Rhomboid-Mediated Cleavage and Leads to Dephosphorylation of Its Cytosolic Tail.

并不是一个简单的束缚：在入侵期间弓形虫Gondii AMA1与RON2的结合可保护AMA1免受菱形介导的裂解，并导致其胞质尾巴的去磷酸化。

• DOI: 10.1128/mbio.00754-16
• 发表时间: 2016-09-13
• 期刊: mBio
• 影响因子: 6.4
• 作者: Krishnamurthy S;Deng B;Del Rio R;Buchholz KR;Treeck M;Urban S;Boothroyd J;Lam YW;Ward GE
• 通讯作者: Ward GE

Synthesis and structural data of tetrabenzo[8]circulene.

• DOI: 10.1002/chem.201304657
• 发表时间: 2014-03-24
• 期刊: CHEMISTRY-A EUROPEAN JOURNAL
• 影响因子: 4.3
• 作者: Miller, Robert W.;Duncan, Alexandra K.;Schneebeli, Severin T.;Gray, Danielle L.;Whalley, Adam C.
• 通讯作者: Whalley, Adam C.

Acetate supplementation as a means of inducing glioblastoma stem-like cell growth arrest.

补充乙酸作为诱导胶质母细胞瘤干细胞生长停滞的一种手段。

• DOI: 10.1002/jcp.24927
• 发表时间: 2015-08
• 期刊: JOURNAL OF CELLULAR PHYSIOLOGY
• 影响因子: 5.6
• 作者: Long, Patrick M.;Tighe, Scott W.;Driscoll, Heather E.;Fortner, Karen A.;Viapiano, Mariano S.;Jaworski, Diane M.
• 通讯作者: Jaworski, Diane M.

Metagenomic analysis of an ecological wastewater treatment plant's microbial communities and their potential to metabolize pharmaceuticals.

• DOI: 10.12688/f1000research.9157.1
• 发表时间: 2016
• 期刊: F1000Research
• 作者: Balcom IN;Driscoll H;Vincent J;Leduc M
• 通讯作者: Leduc M