Development Core-003

开发核心-003

• 批准号: 10660386
• 负责人: MARIA PISU
• 金额: $ 33.89万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10660386
• 关键词: Address; Alabama; Area; Cancer Burden; Cancer Center; Cancer Control; Cancer Control Research; Cancer Survivor; Caring; Censuses; Collaborations; Communities; Data; Data Analyses; Development; Eligibility Determination; Ensure; Environment; Evaluation; Food Access; Funding; Goals; Health; Health Services Accessibility; Human Resources; Inequity; Institution; Institutional Review Boards; Intervention; Life; Literature; Malignant Neoplasms; Methodology; Mission; National Cancer Advisory Board; National Cancer Institute; Outcome; Peer Review; Phase; Pilot Projects; Postdoctoral Fellow; Poverty; Poverty Areas; Prevention; Process; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk Factors; Rural; Training; Transportation; Universities; University of Alabama at Birmingham Cancer Center; cancer health disparity; career; efficacious intervention; experience; falls; graduate student; improved; member; programs; social; social health determinants; survivorship; synergism; therapy development

DEVELOPMENTAL CORE ABSTRACT The Developmental Core (DC) supports the mission of the University of Alabama at Birmingham (UAB)'s Center for Cancer Control in Persistent Poverty Areas (C3P2) to reduce the burden of cancer and cancer disparities in Persistent Poverty (PP) areas by expanding research and research capacity through implementation and evaluation of multilevel interventions to improve cancer outcomes across the cancer control continuum from prevention to survivorship. The DC expands research in cancer control in (PP) areas of Alabama by developing a research program that builds on the overarching research framework and the proposed research projects. This goal will be achieved by identifying and developing pilot projects in synergy with the C3P2 Community Advisory board (CAB) and the National Cancer Institute (NCI)'s Persistent Poverty Initiative Network (PPIN). The DC will bring together C3P2 investigators, including trainees from the Career Enhancement Core (CEC) and CAB members in a process to identify, select, and prioritize the most relevant and feasible pilot projects. Participation in cross-PPIN centers' collaborative projects will also be considered in this process. With this plan, the DC ensures that pilot projects address the needs and context of PP census tracts and fall within the themes of C3P2 and within the larger goals of the PPIN. Potential pilot projects will build on the current projects that examine the impact of changes in the Living Environment and the adaptation of efficacious interventions to improve cancer outcomes in PP areas, and may investigate multi-level interventions to address needs such as low food access and lack of transportation, as well as specific needs to improve cancer survivors' health. The DC also support the C3P2 mission of expanding research capacity in PP areas by providing research experience opportunities to CEC trainees and other investigators not affiliated with the center, and requiring pilot projects have at least one early career investigator as PI or investigator. All projects will be peer-reviewed to ensure scientific rigor and integrity. The DC will have at least two active projects in each funded year. Lastly, the DC will support the development and implementation of the pilot projects by coordinating the use of resources from the Research and Methods Core (RMC) and the Administrative Core (AC), supporting investigators with IRB applications, training, identifying personnel as needed, and evaluating progress. Thus, the DC is well poised to successfully support the C3P2 and contribute to the goals of the PPIN.

核心摘要 发展核心（DC）支持亚拉巴马大学伯明翰分校（UAB）的使命， 持续贫困地区癌症控制中心（C3P2），减轻癌症和癌症负担 通过扩大研究和研究能力， 实施和评估多层次干预措施，以改善癌症患者的预后 从预防到生存的控制连续体。DC扩大了（PP）地区癌症控制的研究 亚拉巴马通过开发一个研究计划，建立在总体研究框架和 提出的研究项目。这一目标将通过协同确定和发展试点项目来实现 与C3P2社区咨询委员会（CAB）和国家癌症研究所（NCI）的持续贫困 倡议网络。DC将召集C3P2调查人员，包括职业培训的受训人员 增强核心（CEC）和CAB成员在一个过程中，以确定，选择，并优先考虑最相关的 可行的试点项目。参与跨PPIN中心的合作项目也将被考虑， 这个过程通过这一计划，数据中心确保试点项目满足PP普查的需求和背景 这些都属于C3P2的主题和PPIN的更大目标。潜在的试点项目将 建立在目前的项目，研究在生活环境和适应变化的影响 有效的干预措施，以改善PP地区的癌症预后，并可能研究多水平 采取干预措施，以解决诸如粮食供应不足和缺乏交通等需求，以及 改善癌症幸存者的健康。DC还支持C3P2的使命， PP领域，为CEC学员和其他非附属研究者提供研究经验机会 与中心合作，并要求试点项目至少有一名早期职业研究者作为PI或研究者。所有 将对项目进行同行审查，以确保科学的严谨性和完整性。DC将至少有两个活跃的 每个资助年度的项目。最后，发展委员会将支持试点项目的开发和实施， 通过协调使用来自研究和方法核心（RMC）和 管理核心（AC），支持研究者提交IRB申请，培训，确定人员 需要，并评估进展情况。因此，DC已做好充分准备，成功支持C3P2，并为 实现PPIN的目标。