Core 3: Assessment and Analysis Shared Resource Core

核心3：评估与分析共享资源核心

• 批准号: 10247790
• 负责人: MARIA PISU
• 金额: $ 58.69万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10247790
• 关键词: Accelerometer; Aging; Alabama; Algorithms; Behavior; Behavior Therapy; Behavioral; Biological; Biological Markers; Biometry; Blood; Body Composition; Cancer Survivor; Cancer Survivorship; Cataloging; Characteristics; Collaborations; Collection; Complex; Comprehensive Cancer Center; Consent; Consultations; Cost Effectiveness Analysis; Cost Savings; Data; Data Collection; Data Store; Dissemination and Implementation; Doctor of Philosophy; Environment; Equation; Fostering; Goals; Health; Health Care Costs; Home visitation; Human Resources; Inflammation; International; Intervention; Knowledge; Label; Laboratories; Life Style; Link; Malignant Neoplasms; Mediator of activation protein; Methodology; Minority; Modeling; Monitor; Nurses; Outcome; Participant; Physical Function; Physical Performance; Population; Positioning Attribute; Procedures; Process; Quality Control; Quality of life; Quality-Adjusted Life Years; Questionnaires; Randomized; Research; Research Design; Research Personnel; Resource Sharing; Resources; Rural; Rural Minority; Sampling; Savings; Science; Secure; Self Administration; Services; Shipping; Societies; Statistical Data Interpretation; Structure; Subgroup; Surveys; Survivors; System; Telephone; Testing; Training; Treatment Efficacy; Universities; Urine; Waiting Lists; Work; adjudicate; arm; central database; cost; cost effectiveness; data management; data quality; data sharing; effectiveness evaluation; efficacy testing; experience; immune function; implementation cost; implementation intervention; improved; improved outcome; neoplasm registry; primary outcome; recruit; research study; sample collection; screening; secondary outcome; study population; underserved minority

The primary objective of the AMPLIFI Assessment and Analysis (AA) Shared Resource Core (SRC) is to support the scientific objectives of all AMPLIFI projects and SRCs through data and biospecimen collection, data management, and statistical and cost-effectiveness analysis. The AA SRC will work in collaboration with and assist the Recruitment and Retention (RR) and Adaptation, Dissemination, and Implementation (ADI) and the Administration (ADMIN) SRCs, and leverage exceptional resources at the University of Alabama at Birmingham. The AA SRC's specific aims are: (1) To implement the AMPLIFI study design. The AA SRC will randomize 652 survivors to the AMPLIFI study arms using block randomization; (2) To facilitate AMPLIFI data collection, entry and management. The AA SRC will enter or download, manage, clean, and link all AMPLIFI data obtained from cancer registries, screening and recruitment process, participants' assessments, and laboratories. A REDCap system will be set up to track data collection materials sent and received. Participants' assessments will consist of self-administered questionnaires, phone surveys, home visits (which include blood and urine sample collection) and accelerometer monitoring. Home visits will be conducted by Examination Management Services Inc. (EMSI), a company with trained nurses used in previous research studies. The AA SRC will process, prepare for statistical analysis, and store data from AMPLIFI projects and ADI and RR SRCs; (3) To plan and conduct statistical analyses for AMPLIFI Projects and Cores. The AA SRC provides expert statistical and methodological consultation to project investigators and SRC leaders by planning and conducting statistical analyses in support of AMPLIFI projects, and additional analyses for the RR and ADI SRCs. This will include testing the efficacy of the AMPLIFI interventions on the primary outcomes, exploring the interventions' impact on secondary outcomes (including quality of life, physical functioning and performance, body composition, and biomarkers of inflammation, immune function, and successful aging), conducting mediator/moderator analyses to ascertain the constructs by which the intervention exerts its effects and the key survivor characteristics that influence intervention efficacy; and (4) To plan and conduct cost- effectiveness analyses of the AMPLIFI interventions. The AA SRC will assess if the tested interventions are economically attractive, i.e., assess how interventions' benefits in terms of quality of life gains compare with their net cost (implementation costs – savings in health care costs, if any). Attainment of these aims will contribute to the wider dissemination of the tested interventions by demonstrating their efficacy and cost- effectiveness, the mechanisms by which they work to impact lifestyle behaviors, and in whom they work best. The outstanding AA SRC team has decades of experience in implementing study designs, performing data collection and management, and conducting statistical and cost-effectiveness analyses. Therefore, it is well positioned to contribute to AMPLIFI goals and to the advancement of cancer survivorship research.

AMPLIFI评估和分析（AA）共享资源核心（SRC）的主要目标是 通过数据和生物标本收集，支持所有AMPLIFI项目和SRC的科学目标， 数据管理以及统计和成本效益分析。机管局SRC将与 并协助招聘和保留（RR）以及适应、传播和实施（ADI）， 管理（ADMIN）SRC，并利用亚拉巴马大学的特殊资源， 伯明翰AA SRC的具体目标是：（1）实施AMPLIFI研究设计。AA SRC 将使用区组随机化将652名幸存者随机分配到AMPLIFI研究组;（2）为了促进AMPLIFI 数据收集、输入和管理。AA SRC将输入或下载，管理，清理和链接所有 AMPLIFI数据来自癌症登记、筛查和招募过程、参与者评估， 和实验室。将建立一个REDCap系统，以跟踪发送和接收的数据收集材料。 参与者的评估将包括自填问卷、电话调查、家访（ 包括血液和尿液样本收集）和加速计监测。家访将由 考试管理服务公司（EMSI），一家拥有受过训练的护士的公司， 问题研究AA SRC将处理、准备统计分析并存储来自AMPLIFI项目的数据， （3）规划和开展非洲粮食计划署国际粮食计划署项目和核心的统计分析。机管局 SRC为项目调查人员和SRC领导人提供专家统计和方法咨询， 规划和开展统计分析，以支持非洲区域发展伙伴关系项目，并对经常资源进行额外分析 ADI SRC这将包括测试AMPLIFI干预措施对主要成果的功效， 探讨干预措施对次要结局（包括生活质量、身体功能和 性能、身体组成和炎症、免疫功能和成功衰老的生物标志物）， 进行中介人/调节人分析，以确定干预发挥其效果的结构 以及影响干预效果的关键幸存者特征;（4）计划和实施成本- 对AMPLIFI干预措施的有效性进行分析。AA SRC将评估测试的干预措施是否 在经济上是有吸引力的，即，评估干预措施在提高生活质量方面的效益如何比较 其净成本（执行成本-节省的保健费用，如果有的话）。实现这些目标将 * 通过展示其功效和成本，促进更广泛地传播经过测试的干预措施， 有效性，他们影响生活方式行为的机制，以及他们最好的工作对象。 杰出的AA SRC团队在实施研究设计、执行数据分析、 收集和管理，并进行统计和成本效益分析。因此， 致力于实现AMPLIFI目标和促进癌症生存研究。