Neonatal therapy for improving myelination and long term outcome following preterm birth

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Preterm birth leads to the early loss of the nurturing uterine environment which supports key developmental processes. This results in behavioural disorders later in life including attention deficit hyperactivity disorder and anxiety. Preterm birth leads to loss of support for the maturation of oligodendrocyte cells and myelination which contributes to these disorders. This work will delineate therapies for preterm neonates that restore myelination and improve long-term behavioural outcomes.