The Early Life Exposome and Childhood Health - The Colorado Healthy Start 3 Cohort Study

早期生命暴露组和儿童健康 - 科罗拉多健康开始 3 队列研究

• 批准号: 10002318
• 负责人: Dana Dabelea
• 金额: $ 246.22万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10002318
• 关键词: Acceleration; Age; Air Pollution; Asthma; Behavior; Behavioral; Biogenesis; Biological; Birth; Blood Vessels; Body Composition; Chemicals; Child; Child Health; Childhood; Chronic Disease; Cohort Studies; Collaborations; Colorado; Complex; Conceptions; Development; Developmental Disabilities; Diabetes Mellitus; Diagnosis; Diet; Disease; Environmental Exposure; Etiology; Evaluation; Exposure to; Extracellular Domain; Foundations; Future; Goals; Growth; Health; Individual; Infant; Life; Life Style; Link; Measures; Mediator of activation protein; Mesenchymal Stem Cells; Metabolic; Metabolism; Molecular; Mothers; Neonatal; Neurocognitive; Normal Range; Nutritional; Obesity; Outcome; Overnutrition; Pathway interactions; Pattern; Phenotype; Physical activity; Physiology; Placenta; Positioning Attribute; Pregnancy; Prevention; Protocols documentation; Public Health; Research; Risk; Sampling; Scientific Advances and Accomplishments; Sleep; Structure; Sum; Time; Umbilical Cord Blood; Woman; Work; built environment; cardiometabolism; cohort; disorder risk; early childhood; early life exposure; epidemiology study; epigenome; follow-up; gene environment interaction; in utero; innovation; non-genetic; offspring; postnatal; prenatal; prenatal environmental exposure; prospective; recruit; respiratory; response; social; trait

PROJECT SUMMARY In response to RFA-OD-16-004, our overarching goal is to determine the early life “exposome”, across a wide range of exposures (social, lifestyle, nutritional, chemical, physical), and conduct integrative analyses with child health outcomes that are informed by biological pathways and account for postnatal factors. We propose to leverage an existing, ongoing pre-birth cohort in Colorado, Healthy Start, which has recruited and is currently following 1410 mother-child dyads up to age 4-5 years (R01DK076648, PI Dabelea). Biological samples have been collected during pregnancy, at birth, and are now being obtained at age 4-5 years. Our study proposes to leverage this cohort by accomplishing the following aims: AIM 1: Expand the assessment of prenatal and early life environmental exposures (air pollution, built environment) and add to exposures already measured (social, lifestyle, nutritional, chemical) to define exposure patterns (external domain of the exposome); AIM 2: Measure biological signatures (internal domain of the exposome) associated with prenatal environmental exposures in subsets of children with available samples (cord blood, umbilical-derived mesenchymal stem cells, and placentas); AIM 3: Continue the longitudinal follow up of the cohort to age 7-8 years focusing on obesity, vascular, metabolic, neurocognitive and respiratory outcomes, as well as postnatal social and behavioral factors; AIM4: Conduct integrative analyses to assess the relationships of multiple and combined early life exposures with child outcomes. Biological, social and behavioral pathways and mediators will be explored. Our study is poised to integrate estimates of already available and newly measured environmental exposures operating during prenatal/early life, together with their biological signatures and likely effects on developmental behaviors, to provide a first step in the much needed holistic understanding of the etiology of childhood chronic diseases. By continuing to longitudinally follow up the Colorado Healthy Start cohort and collaborating with the larger ECHO consortium we will be able to expand the scope of our work, by refining and incorporating additional components of the exposome, exploring changes in the composition and impact of the exposome over time, targeting additional childhood outcomes, and participating in large gene-environment interaction studies.

项目概要 为了回应 RFA-OD-16-004，我们的首要目标是确定早期生命“暴露组”， 涵盖广泛的接触（社会、生活方式、营养、化学、物理）和行为 通过生物途径和信息对儿童健康结果进行综合分析 考虑到后天因素。我们建议利用现有的、持续的产前队列 科罗拉多州 Healthy Start，已招募并正在追踪 1410 名母子夫妻 4-5 岁以下（R01DK076648，PI Dabelea）。生物样本已采集 在怀孕期间、出生时以及现在在 4-5 岁时获得。我们的研究建议 通过实现以下目标来利用这一群体： 目标 1：扩大对产前和生命早期环境暴露的评估（空气污染、 建筑环境）并添加到已经测量的暴露（社会、生活方式、营养、 化学）来定义暴露模式（暴露组的外部域）； 目标 2：测量与相关的生物特征（暴露组的内部结构域） 拥有可用样本（脐带血、 脐带间充质干细胞和胎盘）； 目标 3：继续对队列进行纵向随访至 7-8 岁，重点关注肥胖、 血管、代谢、神经认知和呼吸系统结果，以及产后社会和 行为因素； AIM4：进行综合分析以评估多个和组合早期的关系 生活暴露与儿童结局。生物、社会和行为途径和中介 将被探索。 我们的研究准备整合现有的和新测量的估计 产前/生命早期的环境暴露及其生物 特征和对发展行为的可能影响，为许多方面提供了第一步 需要对儿童慢性病的病因学有全面的了解。通过继续 纵向跟进科罗拉多健康开始队列并与更大的合作 ECHO 联盟，我们将能够通过完善和合并来扩大我们的工作范围 暴露组的其他成分，探索其成分和影响的变化 随着时间的推移，以额外的儿童成果为目标，并参与大型活动 基因-环境相互作用研究。