Super Resolution for Improved Multislice Prostate MRI

超分辨率改进的多层前列腺 MRI

• 批准号: 10661095
• 负责人: Stephen J Riederer
• 金额: $ 56.55万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-10 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661095
• 关键词: 3-Dimensional; Abbreviations; Algorithms; Cancer Detection; Clinical; Collaborations; Data; Development; Diagnosis; Diagnostic; Diffusion Magnetic Resonance Imaging; Early Diagnosis; Encapsulated; Feasibility Studies; Grant; Image; Individual; Magnetic Resonance Imaging; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Methodology; Methods; Motion; Normal tissue morphology; Outcome; Pathology; Performance; Peristalsis; Physiologic pulse; Prostate; Qualifying; Radiology Specialty; Relaxation; Reporting; Resolution; Scanning; Scheme; Screening for Prostate Cancer; Slice; Survival Rate; Techniques; Thick; Thinness; Time; Urology; Visualization; diagnostic accuracy; diffusion weighted; image reconstruction; improved; in vivo; innovation; men; rapid technique; reconstruction; research clinical testing; two-dimensional; ultra high resolution; virtual

PROJECT SUMMARY / ABSTRACT Prostate cancer (PCa) is the most common and second most deadly non-cutaneous cancer in men in the USA, but five-year survival rates approaching 100% are possible if detected early. Prostate MRI has become increasingly important in cancer detection and localization. Two-dimensional (2D) multislice T2-weighted spin-echo (T2SE) and diffusion-weighted (DWI) acquisitions are mainstays of clinical prostate MRI, but radi- ological interpretation is hindered because through-plane resolution is 3–8× coarser than inplane resolution. This is particularly limiting in the transition zone (TZ) of the prostate where differences in relaxation times between malignant and normal tissue are small, and interpretation is often based on sharpness-related criteria such as encapsulation. Per PI-RADSv2.1, T2SE is the critical sequence. Reported sensitivity is far less than ideal, 30 to 70%. In addition to the specific need for improved diagnostic accuracy in the TZ, there is an initiative to make prostate MRI exams shorter and more efficient. Thus, there is a need to reconcile these competing demands of improved resolution and contrast via reduced partial volume effects with higher effi- ciency in prostate MRI. We have developed a super resolution (SR) method for T2SE which uses overlapped, standard-thickness (3mm) axial slices to form 1mm slices with reconstruction in kZ-space, dubbed kZ-multislice (KZM). We have shown in vivo the superior sharpness of the resultant images vs. 3mm slices for equal inplane resolution. More recently we have developed methods which virtually eliminate the slice-to-slice in- consistency disrupting current KZM reconstruction and degrading image quality. Our central hypothesis is that this KZM approach shown in feasibility studies can now be markedly improved technically to simultane- ously provide improved through-plane resolution and allow reduced scan time, resulting in an efficient tech- nique enabling improved performance of clinical prostate T2SE and DWI MRI. We propose to: 1. Develop techniques for rapid, high quality, multislice acquisition suitable for SR prostate T2SE. We will incorporate non-traditional RF excitation pulses for improved fidelity in kZ. We will use simultaneous multi- slice (SMS) to reduce scan time and statistical reconstruction to retain SNR. We will develop means to measure the small, 1-2 mm A/P prostate motion during the scan, allowing accurate motion correction. 2. Extend the SR methodology developed for T2SE to DWI of the prostate. Segmented acquisition will provide for slice-to-slice positional consistency. SR reconstruction will be tuned to the individual b-values used. Sta- tistical reconstruction will retain SNR, allowing thin-slice images of the ADC. 3. Apply SR techniques to multislice prostate MRI. We will evaluate our technical developments in clinical evaluations, comparing conventional T2SE with our new SR method for a Super Abbreviated Exam (SAE). We will also evaluate our T2SE KZM method on improved accuracy in detecting PCa in the transition zone.

项目摘要/摘要 前列腺癌（PCa）是男性中最常见和第二致命的非皮肤癌， 美国，但如果早期发现，五年生存率接近100%是可能的。前列腺MRI已经成为 在癌症检测和定位中越来越重要。二维（2D）多层T2加权 自旋回波（T2 SE）和弥散加权（DWI）采集是临床前列腺MRI的主要手段，但放射性成像（MRI） 由于通过平面的分辨率比平面内的分辨率粗3-8倍，因此阻碍了逻辑解释。 这在前列腺的移行区（TZ）中特别受限，在移行区中弛豫时间的差异 恶性组织和正常组织之间的差异很小，并且通常基于与尖锐度相关的标准来解释 例如封装。根据PI-RADSv 2.1，T2 SE是关键序列。报告的灵敏度远低于 最好是30 - 70%除了在TZ中提高诊断准确性的具体需求外， 前列腺MRI检查时间更短、效率更高。因此，有必要调和这些问题， 通过降低部分体积效应提高分辨率和对比度的竞争需求， 前列腺MRI检查中的应用我们已经开发了一种用于T2 SE的超分辨率（SR）方法， 标准厚度（3 mm）轴向切片，以形成1 mm切片，并在kZ空间中进行重建，称为kZ多层切片 （KZM）。我们已经在体内显示了与3 mm切片相比，在相同的条件下，所得图像的上级清晰度 面内分辨率最近，我们开发了一些方法，几乎消除了切片- 一致性干扰当前KZM重建并降低图像质量。我们的核心假设是 可行性研究中所示的KZM方法现在可以在技术上显着改进，以同时进行- 提供更高的穿透平面分辨率，并缩短扫描时间，从而实现高效的技术， 独特，能够改善临床前列腺T2 SE和DWI MRI的性能。我们建议： 1.开发适用于SR前列腺T2 SE的快速、高质量、多层采集技术。我们将 结合了非传统RF激励脉冲，以提高kZ保真度。我们将同时使用多个- 切片（SMS），以减少扫描时间和统计重建，以保持SNR。我们将开发方法， 在扫描过程中测量小的1-2 mm A/P前列腺运动，允许精确的运动校正。 2.将为T2 SE开发的SR方法扩展到前列腺DWI。分段收购将提供 以确保切片之间的位置一致性。SR重建将根据所使用的单个b值进行调整。Sta- 组织重建将保留SNR，允许ADC的薄片图像。 3.将SR技术应用于多层前列腺MRI。我们将评估我们的临床技术发展， 评估，比较传统的T2 SE与我们的新SR方法的超级简化考试（SAE）。 我们还将评估我们的T2 SE KZM方法在过渡区检测PCa的准确性。